The Src-Family Kinases SRC and BLK Contribute to the CLDN6-Adhesion Signaling [PDF]
Cells, 2023 Cell adhesion molecules, including integrins, cadherins, and claudins (CLDNs), are known to activate Src-family kinases (SFKs) that organize a variety of physiological and pathological processes; however, the underlying molecular basis remains unclear ...
Naoki Ichikawa-Tomikawa +3 more
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Pharmacological inhibition of Src family kinases attenuates hyperuricemic nephropathy [PDF]
Frontiers in PharmacologyHyperuricemia is an independent risk factor for chronic kidney disease and contributes to renal fibrosis. This study aims to investigate the effect of Src family kinase (SFK) inhibition on the development of hyperuricemic nephropathy (HN) and the ...
Chongxiang Xiong +5 more
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Src Family Kinases: A Potential Therapeutic Target for Acute Kidney Injury [PDF]
Biomolecules, 2022 Src family kinases (SFKs) are non-receptor tyrosine kinases and play a key role in regulating signal transduction. The mechanism of SFKs in various tumors has been widely studied, and there are more and more studies on its role in the kidney.
Nannan Li +8 more
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Phosphorylation of Unique domains of Src family kinases [PDF]
Frontiers in Genetics, 2014 Members of the Src family of kinases (SFKs) are non-receptor tyrosine kinases involved innumerous signal transduction pathways. The catalytic, SH3 and SH2 domains are attached tothe membrane-anchoring SH4 domain through the intrinsically disordered ...
Irene eAmata +3 more
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Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition [PDF]
Cell Communication and Signaling, 2021 Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement on SRC function. However, a significant body of work has defined Src family kinases as key players in tumor progression, invasion and metastasis in human ...
Maria A. Ortiz +5 more
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Platelet Src family kinases: A tale of reversible phosphorylation [PDF]
Research and Practice in Thrombosis and Haemostasis, 2021 Sarcoma (Src) family kinases (SFKs) have occupied a central place in platelet research for over 40 years. Discovered by virologists and oncologists as the proto proto‐oncogene, Src tyrosine kinase spurred a phenomenal burst of research on reversible ...
Yotis A. Senis +4 more
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Src family kinases engage differential pathways for encapsulation into extracellular vesicles [PDF]
Journal of Extracellular Biology, 2023 Extracellular vesicles (EVs) are heterogeneous biological nanoparticles secreted by all cell types. Identifying the proteins preferentially encapsulated in secreted EVs will help understand their heterogeneity.
Chenming Ye +10 more
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Regulation of the Src Family Kinases by Csk [PDF]
International Journal of Biological Sciences, 2012 The non-receptor tyrosine kinase Csk serves as an indispensable negative regulator of the Src family tyrosine kinases (SFKs) by specifically phosphorylating the negative regulatory site of SFKs, thereby suppressing their oncogenic potential.
Masato Okada
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Src Family Kinases Inhibition Ameliorates Hypoxic-Ischemic Brain Injury in Immature Rats [PDF]
Frontiers in Cellular Neuroscience, 2021 Hypoxic-ischemic (HI) injury is one of the initial factors contributing to neonatal brain injury. Src family kinases (SFKs) are considered to act as molecular hubs for N-methyl-d-aspartate receptor (NMDAR) regulation and participate in the HI injury ...
Han Qiu +5 more
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Structural insights into redox-active cysteine residues of the Src family kinases [PDF]
Redox Biology, 2021 The Src Family Kinases (SFKs) are pivotal regulators of cellular signal transduction and highly sought-after targets in drug discovery. Their actions within cells are controlled by alterations in protein phosphorylation that switch the SFKs from ...
David E. Heppner
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