Results 11 to 20 of about 112,075 (284)

Phosphorylation of Unique domains of Src family kinases [PDF]

Frontiers in Genetics, 2014
Members of the Src family of kinases (SFKs) are non-receptor tyrosine kinases involved innumerous signal transduction pathways. The catalytic, SH3 and SH2 domains are attached tothe membrane-anchoring SH4 domain through the intrinsically disordered ...
Irene eAmata, Irene eAmata, Mariano eMaffei, Miquel ePons   +3 more
doaj   +4 more sources

Structure and regulation of Src family kinases [PDF]

Oncogene, 2004
Src family kinases are prototypical modular signaling proteins. Their conserved domain organization includes a myristoylated N-terminal segment followed by SH3, SH2, and tyrosine kinase domains, and a short C-terminal tail. Structural dissection of Src kinases has elucidated the canonical mechanisms of phosphotyrosine recognition by the SH2 domain and ...
Titus J, Boggon, Michael J, Eck
openaire   +4 more sources

The interplay between Src family kinases and receptor tyrosine kinases. [PDF]

Oncogene, 2004
Src family tyrosine kinases (SFKs) are involved in a diverse array of physiological processes, as highlighted in this review. An overview of how SFKs interact with, and participate in signaling from, receptor tyrosine kinases (RTKs) is discussed.
Bromann, Paul Andrew, Courtneidge, Sara A., Korkaya, Hasan   +2 more
core   +4 more sources

Mindin regulates fibroblast subpopulations through distinct Src family kinases during fibrogenesis [PDF]

JCI Insight
Fibrosis results from excessive extracellular matrix (ECM) deposition, which causes tissue stiffening and organ dysfunction. Activated fibroblasts, central to fibrosis, exhibit increased migration, proliferation, contraction, and ECM production. However,
Sunny Kataria, Isha Rana, Krithika Badarinath, Rania F. Zaarour, Gaurav Kansagara, Sultan Ahmed, Abrar Rizvi, Dyuti Saha, Binita Dam, Abhik Dutta, Ravindra K. Zirmire, Edries Yousaf Hajam, Pankaj Kumar, Akash Gulyani, Colin Jamora   +14 more
doaj   +2 more sources

Src family kinases and pulmonary fibrosis: A review

Biomedicine & Pharmacotherapy, 2020
Src family kinases (SFKs) is a non-receptor protein tyrosine kinases family. They are crucial in signal transduction and regulation of various cell biological processes, such as proliferation, differentiation and apoptosis. The role and mechanism of SFKs in tumorigenesis have been widely studied. However, more and more studies have also shown that SFKs
Hang, Li, Caiping, Zhao, Ye, Tian, Juan, Lu, Guiyu, Zhang, Shuang, Liang, Dongfeng, Chen, Xiaohong, Liu, Weihong, Kuang, Meiling, Zhu   +9 more
openaire   +4 more sources

Regulation of the Src Family Kinases by Csk [PDF]

International Journal of Biological Sciences, 2012
The non-receptor tyrosine kinase Csk serves as an indispensable negative regulator of the Src family tyrosine kinases (SFKs) by specifically phosphorylating the negative regulatory site of SFKs, thereby suppressing their oncogenic potential.
Masato Okada
doaj   +3 more sources

Myeloid Src-family kinases are critical for neutrophil-mediated autoinflammation in gout and motheaten models. [PDF]

J Exp Med, 2023
Futosi K, Németh T, Horváth ÁI, Abram CL, Tusnády S, Lowell CA, Helyes Z, Mócsai A.   +7 more
europepmc   +2 more sources

Src Dependent Pancreatic Acinar Injury Can Be Initiated Independent of an Increase in Cytosolic Calcium [PDF]

, 2013
Several deleterious intra-acinar phenomena are simultaneously triggered on initiating acute pancreatitis. These culminate in acinar injury or inflammatory mediator generation in vitro and parenchymal damage in vivo. Supraphysiologic caerulein is one such
A Gnoni, A Pace, A Sharma, AJ Hietaranta, AK Saluja, AK Saluja, AS Gukovskaya, B Han, B Han, B Hofbauer, B Kruger, C Schafer, Catherine J. Baty, CH Kubisch, Chandra Durgampudi, Chathur Acharya, DN Criddle, Donna B. Stolz, EC Thrower, EM Parker, F Gorelick, F Mooren, F Nozu, G Lynch, H Weber, HK Baumgartner, I Gukovsky, I Gukovsky, I Samuel, JA Tapia, JA Williams, Jenny Karlsson, JV Gerasimenko, KA Muili, Krutika Patel, L Fischer, L Orlichenko, Lidiya Orlichenko, LJ Christopher, LJ Lombardo, LS Orlichenko, M Sendler, MS O'Konski, OA Mareninova, OH Petersen, Pawan Noel, PC Redondo, Rachel Cline, Ram Narayan Trivedi, RD Duan, RR Torgerson, RR Torgerson, S Kawabata, S Navina, Sarah Navina, SD Waterford, SG Weller, SJ Pandol, Sohail Z. Husain, Stuart E. Dryer, SZ Husain, SZ Husain, T Eley, T Grady, T Grady, V Sancho, Vijay P. Singh, Vivek Mishra, VP Singh, VP Singh, VP Singh, VP Singh, Y Tsunoda   +72 more
core   +17 more sources

The tyrosine kinase Csk dimerizes through Its SH3 domain. [PDF]

PLoS ONE, 2009
The Src family kinases possess two sites of tyrosine phosphorylation that are critical to the regulation of kinase activity. Autophosphorylation on an activation loop tyrosine residue (Tyr 416 in commonly used chicken c-Src numbering) increases catalytic
Nicholas M Levinson, Patrick R Visperas, John Kuriyan   +2 more
doaj   +1 more source

Src family kinases and paclitaxel sensitivity [PDF]

Cancer Biology & Therapy, 2011
Src-family Kinases (SFKs) participate in the regulation of proliferation, differentiation, apoptosis, autophagy, adhesion, migration, invasion and angiogenesis in normal and cancer cells. Abnormal expression of SFKs has been documented in cancers that arise in breast, colon, ovary, melanocyte, gastric mucosa, head and neck, pancreas, lung, and brain ...
Xiao-Feng, Le, Robert C, Bast
openaire   +2 more sources