Role of Src family kinases Fyn and Lyn in arenavirus infection [PDF]
Journal of VirologyArenaviruses encompass a diverse group of infectious agents, some of which, like Lassa virus (LASV), pose significant threats to global public health due to their acute virulence, while others, such as lymphocytic choriomeningitis virus (LCMV), are less ...
Wenting Mao +11 more
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Targeting SRC Family Kinases in Mesothelioma: Time to Upgrade. [PDF]
Cancers (Basel), 2020 Malignant mesothelioma (MM) is a deadly tumor mainly caused by exposure to asbestos. Unfortunately, no current treatment is able to change significantly the natural history of the disease, which has a poor prognosis in the majority of patients. The non-receptor tyrosine kinase SRC and other SRC family kinase (SFK) members are frequently hyperactivated ...
Indovina P +3 more
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Src family kinases and pulmonary fibrosis: A review
Biomedicine and Pharmacotherapy, 2020 Src family kinases (SFKs) is a non-receptor protein tyrosine kinases family. They are crucial in signal transduction and regulation of various cell biological processes, such as proliferation, differentiation and apoptosis. The role and mechanism of SFKs in tumorigenesis have been widely studied. However, more and more studies have also shown that SFKs
Weihong Kuang, Meiling Zhu, Hang Li
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Mindin regulates fibroblast subpopulations through distinct Src family kinases during fibrogenesis [PDF]
JCI InsightFibrosis results from excessive extracellular matrix (ECM) deposition, which causes tissue stiffening and organ dysfunction. Activated fibroblasts, central to fibrosis, exhibit increased migration, proliferation, contraction, and ECM production. However,
Sunny Kataria +14 more
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Src family kinases in chronic kidney disease. [PDF]
Am J Physiol Renal Physiol, 2017 Src family kinases (SFKs) belong to nonreceptor protein tyrosine kinases and have been implicated in the regulation of numerous cellular processes, including cell proliferation, differentiation, migration and invasion, and angiogenesis. The role and mechanisms of SFKs in tumorgenesis have been extensively investigated, and some SFK inhibitors are ...
Wang J, Zhuang S.
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Myeloid Src-family kinases are critical for neutrophil-mediated autoinflammation in gout and motheaten models [PDF]
Journal of Experimental Medicine, 2023 Tamás Nemeth +2 more
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Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications [PDF]
Cancers, 2020 Wook Jin, Jin Wook
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Src family kinases and paclitaxel sensitivity [PDF]
Cancer Biology & Therapy, 2011 Src-family Kinases (SFKs) participate in the regulation of proliferation, differentiation, apoptosis, autophagy, adhesion, migration, invasion and angiogenesis in normal and cancer cells. Abnormal expression of SFKs has been documented in cancers that arise in breast, colon, ovary, melanocyte, gastric mucosa, head and neck, pancreas, lung, and brain ...
Xiao-Feng, Le, Robert C, Bast
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Structure and regulation of Src family kinases [PDF]
Oncogene, 2004 Src family kinases are prototypical modular signaling proteins. Their conserved domain organization includes a myristoylated N-terminal segment followed by SH3, SH2, and tyrosine kinase domains, and a short C-terminal tail. Structural dissection of Src kinases has elucidated the canonical mechanisms of phosphotyrosine recognition by the SH2 domain and ...
Titus J, Boggon, Michael J, Eck
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Src Family Kinases as Therapeutic Targets in Advanced Solid Tumors: What We Have Learned So Far [PDF]
Cancers, 2020 Lorenzo Botta +2 more
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