Results 41 to 50 of about 61,368 (147)
Src-family tyrosine kinases and the Ca2+ signal
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017 In this review, we shall describe the rich crosstalk between non-receptor Src-family kinases (SFKs) and the Ca2+ transient generated in activated cells by a variety of extracellular and intracellular stimuli, resulting in diverse signaling events. The exchange of information between SFKs and Ca2+ is reciprocal, as it flows in both directions.
Anguita, Estefanía, Villalobo, Antonio
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Reengineering the Signaling Properties of a Src Family Kinase [PDF]
Biochemistry, 2009 Src family kinases (SFKs) are modular signaling proteins possessing SH3, SH2, and tyrosine kinase domains. The SH3 and SH2 domains of SFKs have dual roles: they regulate the activity of the kinases, and they also target SFKs to their cellular substrates. We generated a series of novel SFKs by replacing the SH2 and SH3 domains of Hck with the syntrophin
Shalini S, Yadav +4 more
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B cell activation triggered by the formation of the small receptor cluster: a computational study. [PDF]
PLoS Computational Biology, 2011 We proposed a spatially extended model of early events of B cell receptors (BCR) activation, which is based on mutual kinase-receptor interactions that are characteristic for the immune receptors and the Src family kinases. These interactions lead to the
Beata Hat +2 more
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SRC: A Century of Science Brought to the Clinic
Neoplasia: An International Journal for Oncology Research, 2010 The SRC family kinases are the largest family of norreceptor tyrosine kinases and one of the best-studied targets for cancer therapy. SRC, arguably the oldest oncogene, has been implicated in pathways regulating proliferation, angiogenesis, invasion and ...
Alexey Aleshin, Richard S. Finn
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Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner. [PDF]
PLoS ONE, 2012 The HIV-1 accessory factor Nef is essential for high-titer viral replication and AIDS progression. Nef function requires interaction with many host cell proteins, including specific members of the Src kinase family.
Purushottam S Narute, Thomas E Smithgall
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A role for the protein tyrosine phosphatase CD45 in macrophage adhesion through the regulation of paxillin degradation. [PDF]
PLoS ONE, 2013 CD45 is a protein tyrosine phosphatase expressed on all cells of hematopoietic origin that is known to regulate Src family kinases. In macrophages, the absence of CD45 has been linked to defects in adhesion, however the molecular mechanisms involved ...
Joëlle St-Pierre, Hanne L Ostergaard
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The Src-family Kinase Lyn in Immunoreceptor Signaling
Endocrinology, 2021 AbstractEffective regulation of immune-cell activation is critical for ensuring that the immune response, and inflammation generated for the purpose of pathogen elimination, are limited in space and time to minimize tissue damage. Autoimmune disease can occur when immunoreceptor signaling is dysregulated, leading to unrestrained inflammation and organ ...
Ben F Brian, Tanya S Freedman
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PLoS ONE, 2018 Studies have demonstrated that the solute carrier family 11 member 1 (SLC11A1) is heavily glycosylated and phosphorylated in macrophages. However, the mechanisms of SLC11A1 phosphorylation, and the effects of phosphorylation on SLC11A1 activity remain ...
Yong Zhong Xu +4 more
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Real-time analysis of imatinib- and dasatinib-induced effects on chronic myelogenous leukemia cell interaction with fibronectin. [PDF]
PLoS ONE, 2014 Attachment of stem leukemic cells to the bone marrow extracellular matrix increases their resistance to chemotherapy and contributes to the disease persistence.
Adam Obr +3 more
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Src family kinases: at the forefront of platelet activation [PDF]
Blood, 2014 AbstractSrc family kinases (SFKs) play a central role in mediating the rapid response of platelets to vascular injury. They transmit activation signals from a diverse repertoire of platelet surface receptors, including the integrin αIIbβ3, the immunoreceptor tyrosine–based activation motif–containing collagen receptor complex GPVI-FcR γ-chain, and the ...
Yotis A, Senis +2 more
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