Results 41 to 50 of about 64,838 (284)
Reengineering the Signaling Properties of a Src Family Kinase [PDF]
Biochemistry, 2009 Src family kinases (SFKs) are modular signaling proteins possessing SH3, SH2, and tyrosine kinase domains. The SH3 and SH2 domains of SFKs have dual roles: they regulate the activity of the kinases, and they also target SFKs to their cellular substrates. We generated a series of novel SFKs by replacing the SH2 and SH3 domains of Hck with the syntrophin
Shalini S, Yadav +4 more
openaire +2 more sources
Scientific Reports, 2017 Src-family kinases, expressed in a wide variety of cell types, are anchored to cellular membranes through posttranslational lipid modifications and involved in diverse cellular signalling.
Takao Morinaga +4 more
doaj +1 more source
Src mediates cytokine-stimulated gene expression in airway myocytes through ERK MAPK
Cell Communication and Signaling, 2011 The p38 and extracellular signal-regulated kinases (ERK) mitogen-activated protein kinases (MAPK) participate in cytokine-stimulated inflammatory gene expression in airway smooth muscle cells.
Halayko Andrew J +4 more
doaj +1 more source
Src-family tyrosine kinases and the Ca2+ signal
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017 In this review, we shall describe the rich crosstalk between non-receptor Src-family kinases (SFKs) and the Ca2+ transient generated in activated cells by a variety of extracellular and intracellular stimuli, resulting in diverse signaling events. The exchange of information between SFKs and Ca2+ is reciprocal, as it flows in both directions.
Anguita, Estefanía, Villalobo, Antonio
openaire +3 more sources
B cell activation triggered by the formation of the small receptor cluster: a computational study. [PDF]
PLoS Computational Biology, 2011 We proposed a spatially extended model of early events of B cell receptors (BCR) activation, which is based on mutual kinase-receptor interactions that are characteristic for the immune receptors and the Src family kinases. These interactions lead to the
Beata Hat +2 more
doaj +1 more source
Src family kinases: at the forefront of platelet activation [PDF]
Blood, 2014 AbstractSrc family kinases (SFKs) play a central role in mediating the rapid response of platelets to vascular injury. They transmit activation signals from a diverse repertoire of platelet surface receptors, including the integrin αIIbβ3, the immunoreceptor tyrosine–based activation motif–containing collagen receptor complex GPVI-FcR γ-chain, and the ...
Yotis A, Senis +2 more
openaire +2 more sources
SRC: A Century of Science Brought to the Clinic
Neoplasia: An International Journal for Oncology Research, 2010 The SRC family kinases are the largest family of norreceptor tyrosine kinases and one of the best-studied targets for cancer therapy. SRC, arguably the oldest oncogene, has been implicated in pathways regulating proliferation, angiogenesis, invasion and ...
Alexey Aleshin, Richard S. Finn
doaj +1 more source
Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner. [PDF]
PLoS ONE, 2012 The HIV-1 accessory factor Nef is essential for high-titer viral replication and AIDS progression. Nef function requires interaction with many host cell proteins, including specific members of the Src kinase family.
Purushottam S Narute, Thomas E Smithgall
doaj +1 more source
, 2020 Small molecule kinase inhibitors that stabilize distinct ATP-binding site conformations can differentially modulate the glob-al conformation of Src-family kinases (SFKs). However, it is unclear which specific ATP-binding site contacts are responsible for
Linglan, Fang +6 more
core +1 more source
A role for the protein tyrosine phosphatase CD45 in macrophage adhesion through the regulation of paxillin degradation. [PDF]
PLoS ONE, 2013 CD45 is a protein tyrosine phosphatase expressed on all cells of hematopoietic origin that is known to regulate Src family kinases. In macrophages, the absence of CD45 has been linked to defects in adhesion, however the molecular mechanisms involved ...
Joëlle St-Pierre, Hanne L Ostergaard
doaj +1 more source