Results 51 to 60 of about 61,368 (147)

Endocytosis and the Src family of non-receptor tyrosine kinases

Biomolecular Concepts, 2014
The regulated intracellular transport of nutrient, adhesion, and growth factor receptors is crucial for maintaining cell and tissue homeostasis. Endocytosis, or endocytic membrane trafficking, involves the steps of intracellular transport that include ...
Reinecke James, Caplan Steve
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SRC kinase-mediated signaling pathways and targeted therapies in breast cancer

Breast Cancer Research, 2022
Breast cancer (BC) has been ranked the most common malignant tumor throughout the world and is also a leading cause of cancer-related deaths among women. SRC family kinases (SFKs) belong to the non-receptor tyrosine kinase (nRTK) family, which has eleven
Juan Luo, Hailin Zou, Yibo Guo, Tongyu Tong, Liping Ye, Chengming Zhu, Liang Deng, Bo Wang, Yihang Pan, Peng Li   +9 more
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Development of the Sensing Platform for Protein Tyrosine Kinase Activity

Biosensors, 2021
A miniature tyrosinase-based electrochemical sensing platform for label-free detection of protein tyrosine kinase activity was developed in this study. The developed miniature sensing platform can detect the substrate peptides for tyrosine kinases, such ...
Lan-Yi Wei, Wei Lin, Bey-Fen Leo, Lik-Voon Kiew, Chia-Ching Chang, Chiun-Jye Yuan   +5 more
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Prion-associated Increases in Src-family Kinases [PDF]

Journal of Biological Chemistry, 2005
The prion diseases result from the generation and propagation of an abnormal conformer of the prion protein. It is unclear how this molecular event disrupts neuronal function and viability. Current evidence argues it is not due to loss of normal prion protein activity or direct toxic effects of the abnormal conformer. Both the normal and abnormal prion
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Dissection of the catalytic and regulatory structure-function relationships of Csk protein tyrosine kinase

Frontiers in Cell and Developmental Biology, 2023
Protein tyrosine kinases (PTKs) are a large enzyme family that regulates many cellular processes. The key to their broad role in signaling is their tunable substrate specificity and regulatory mechanisms that allow each to respond to appropriate ...
Gongqin Sun, Marina K. Ayrapetov
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Tau and src family tyrosine kinases

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2005
The interaction between tau and src family non-receptor tyrosine kinases represents a new function for tau. Mediated by the proline-rich region of tau and the SH3 domain of fyn or src, this interaction has the potential to confer novel cellular activities for tau in the growth cone and in the membrane.
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Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells

Stem Cell Research, 2014
Embryonic stem (ES) cells are characterized by pluripotency, defined as the developmental potential to generate cell lineages derived from all three primary germ layers.
Xiong Zhang, Calvin Simerly, Carrie Hartnett, Gerald Schatten, Thomas E. Smithgall   +4 more
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The interplay between Src family kinases and receptor tyrosine kinases [PDF]

Oncogene, 2004
Src family tyrosine kinases (SFKs) are involved in a diverse array of physiological processes, as highlighted in this review. An overview of how SFKs interact with, and participate in signaling from, receptor tyrosine kinases (RTKs) is discussed. And also, how SFKs are activated by RTKs, and how SFKs, in turn, can activate RTKs, as well as how SFKs can
Paul A, Bromann, Hasan, Korkaya, Sara A, Courtneidge   +2 more
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Optimization of Aminoimidazole Derivatives as Src Family Kinase Inhibitors [PDF]

Molecules, 2018
Protein kinases have emerged as crucial targets for cancer therapy over the last decades. Since 2001, 40 and 39 kinase inhibitors have been approved by FDA and EMA, respectively, and the majority are antineoplastic drugs. Morevoer, many candidates are currently in clinical trials.
Francini, Cinzia Maria, Musumeci, Francesca, Fallacara, Anna Lucia, Botta, Lorenzo, Molinari, Alessio, Artusi, Roberto, Mennuni, Laura, Angelucci, Adriano, Schenone, Silvia   +8 more
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Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation. [PDF]

PLoS ONE, 2011
Src family kinases (SFK) control multiple processes during brain development and function. We show here that the phosphoprotein associated with glycosphigolipid-enriched microdomains (PAG)/Csk binding protein (Cbp) modulates SFK activity in the brain ...
Sabine Lindquist, Diana Karitkina, Kristina Langnaese, Anita Posevitz-Fejfar, Burkhart Schraven, Ramnik Xavier, Brian Seed, Jonathan A Lindquist   +7 more
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