Results 1 to 10 of about 80,567 (286)
Endocytosis and the Src family of non-receptor tyrosine kinases
Biomolecular Concepts, 2014 The regulated intracellular transport of nutrient, adhesion, and growth factor receptors is crucial for maintaining cell and tissue homeostasis. Endocytosis, or endocytic membrane trafficking, involves the steps of intracellular transport that include ...
Reinecke James, Caplan Steve
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Development of the Sensing Platform for Protein Tyrosine Kinase Activity
Biosensors, 2021 A miniature tyrosinase-based electrochemical sensing platform for label-free detection of protein tyrosine kinase activity was developed in this study. The developed miniature sensing platform can detect the substrate peptides for tyrosine kinases, such ...
Lan-Yi Wei +5 more
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Prion-associated Increases in Src-family Kinases [PDF]
Journal of Biological Chemistry, 2005 The prion diseases result from the generation and propagation of an abnormal conformer of the prion protein. It is unclear how this molecular event disrupts neuronal function and viability. Current evidence argues it is not due to loss of normal prion protein activity or direct toxic effects of the abnormal conformer. Both the normal and abnormal prion
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Role of Src Family Kinases in Prolactin Signaling
, 2014 Prolactin (PRL) is a polypeptide hormone/cytokine mainly synthesized by the lactotrophic cells of the adenohypophysis. In addition to the best-known role in mammary gland development and the functional differentiation of its epithelium, PRL is involved in regulation of multiple physiological processes in higher organisms contributing to their ...
Martín-Pérez, Jorge +4 more
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Targeting SRC family kinases in lung cancer
, 2012 Lung cancer is the commonest cancer killer worldwide. This is mainly due to the rapid development of drug resistance and early metastatic dissemination of the disease.
Rupniewska, Ewa
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Frontiers in Cell and Developmental Biology, 2023 Protein tyrosine kinases (PTKs) are a large enzyme family that regulates many cellular processes. The key to their broad role in signaling is their tunable substrate specificity and regulatory mechanisms that allow each to respond to appropriate ...
Gongqin Sun, Marina K. Ayrapetov
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Encodable Activators of Src Family Kinases
, 2016 There is considerable current interest in the design of encodable molecules that regulate intracellular protein circuitry and/or activity, ideally with a high level of specificity.
Sarmistha Saha (2513896) +7 more
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Stem Cell Research, 2014 Embryonic stem (ES) cells are characterized by pluripotency, defined as the developmental potential to generate cell lineages derived from all three primary germ layers.
Xiong Zhang +4 more
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Effect of Src kinase inhibition on metastasis and tumor angiogenesis in human pancreatic cancer [PDF]
, 2007 Tumor angiogenesis is a process that requires migration, proliferation, and differentiation of endothelial cells. We hypothesized that decrease in pancreatic tumor growth due to inhibition of src activity is associated with the inability of src kinase to
Ischenko, Ivan
core
Optimization of Aminoimidazole Derivatives as Src Family Kinase Inhibitors [PDF]
Molecules, 2018 Protein kinases have emerged as crucial targets for cancer therapy over the last decades. Since 2001, 40 and 39 kinase inhibitors have been approved by FDA and EMA, respectively, and the majority are antineoplastic drugs. Morevoer, many candidates are currently in clinical trials.
Francini, Cinzia Maria +8 more
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