Mindin regulates fibroblast subpopulations through distinct Src family kinases during fibrogenesis [PDF]
JCI InsightFibrosis results from excessive extracellular matrix (ECM) deposition, which causes tissue stiffening and organ dysfunction. Activated fibroblasts, central to fibrosis, exhibit increased migration, proliferation, contraction, and ECM production. However,
Sunny Kataria +14 more
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Myeloid Src-family kinases are critical for neutrophil-mediated autoinflammation in gout and motheaten models [PDF]
Journal of Experimental Medicine, 2023 Krisztina Futosi +2 more
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Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications [PDF]
Cancers, 2020 Wook Jin
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Src family kinases and paclitaxel sensitivity [PDF]
Cancer Biology & Therapy, 2011 Src-family Kinases (SFKs) participate in the regulation of proliferation, differentiation, apoptosis, autophagy, adhesion, migration, invasion and angiogenesis in normal and cancer cells. Abnormal expression of SFKs has been documented in cancers that arise in breast, colon, ovary, melanocyte, gastric mucosa, head and neck, pancreas, lung, and brain ...
Xiao-Feng, Le, Robert C, Bast
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Structure and regulation of Src family kinases [PDF]
Oncogene, 2004 Src family kinases are prototypical modular signaling proteins. Their conserved domain organization includes a myristoylated N-terminal segment followed by SH3, SH2, and tyrosine kinase domains, and a short C-terminal tail. Structural dissection of Src kinases has elucidated the canonical mechanisms of phosphotyrosine recognition by the SH2 domain and ...
Titus J, Boggon, Michael J, Eck
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Src Family Kinases as Therapeutic Targets in Advanced Solid Tumors: What We Have Learned So Far [PDF]
Cancers, 2020 Stefano Martellucci +2 more
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The tyrosine kinase Csk dimerizes through Its SH3 domain. [PDF]
PLoS ONE, 2009 The Src family kinases possess two sites of tyrosine phosphorylation that are critical to the regulation of kinase activity. Autophosphorylation on an activation loop tyrosine residue (Tyr 416 in commonly used chicken c-Src numbering) increases catalytic
Nicholas M Levinson +2 more
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Regulation of Fibroblast Cell Polarity by Src Tyrosine Kinase
Biomedicines, 2021 Src protein tyrosine kinases (SFKs) are a family of nonreceptor tyrosine kinases that are localized beneath the plasma membrane and are activated during cell adhesion, migration, and elongation.
Kazuo Katoh
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The Role of Src Family Kinases in Neuroendocrine Tumors [PDF]
Gastroenterology, 2012 [No abstract available]
Capurso, G +2 more
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Targeting Src family kinases inhibits bevacizumab-induced glioma cell invasion. [PDF]
PLoS ONE, 2013 Anti-VEGF antibody therapy with bevacizumab provides significant clinical benefit in patients with recurrent glioblastoma multiforme (GBM). Unfortunately, progression on bevacizumab therapy is often associated with a diffuse disease recurrence pattern ...
Deborah Huveldt +8 more
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