Results 31 to 40 of about 61,468 (247)

Characterization of Novel Src Family Kinase Inhibitors to Attenuate Microgliosis. [PDF]

PLoS ONE, 2015
Microgliosis is a major hallmark of Alzheimer's disease (AD) brain pathology. Aβ peptide is hypothesized to act as a stimulus for microglia leading to activation of non-receptor tyrosine kinases and subsequent secretion of pro-inflammatory cytokines ...
Gunjan D Manocha, Kendra L Puig, Susan A Austin, Kathleen Seyb, Marcie A Glicksman, Colin K Combs   +5 more
doaj   +1 more source

Src-family kinases activation in spinal microglia contributes to central sensitization and chronic pain after lumbar disc herniation

Molecular Pain, 2017
Background Lumbar disc herniation is a major cause of radicular pain, but the underlying mechanisms remain largely unknown. Spinal activation of src-family kinases are involved in the development of chronic pain from nerve injury, inflammation, and ...
Yangliang Huang, Yongyong Li, Xiongxiong Zhong, Yuming Hu, Pan Liu, Yuanshu Zhao, Zhen Deng, Xianguo Liu, Shaoyu Liu, Yi Zhong   +9 more
doaj   +1 more source

The diverse functions of Src family kinases in macrophages [PDF]

Frontiers in Bioscience, 2008
Macrophages are key components of the innate immune response. These cells possess a diverse repertoire of receptors that allow them to respond to a host of external stimuli including cytokines, chemokines, and pathogen-associated molecules. Signals resulting from these stimuli activate a number of macrophage functional responses such as adhesion ...
Clare L, Abram, Clifford A, Lowell
openaire   +2 more sources

The Src family kinases: distinct functions of c-Src, Yes, and Fyn in the liver

Biomolecular Concepts, 2013
The Src family kinases Yes, Fyn, and c-Src play a pivotal role in regulating diverse liver functions such as bile flow, proteolysis, apoptosis, and proliferation and are regulated by anisoosmotic cell volume changes, death receptor ligands, and bile ...
Reinehr Roland, Sommerfeld Annika, Häussinger Dieter   +2 more
doaj   +1 more source

Src mediates cytokine-stimulated gene expression in airway myocytes through ERK MAPK

Cell Communication and Signaling, 2011
The p38 and extracellular signal-regulated kinases (ERK) mitogen-activated protein kinases (MAPK) participate in cytokine-stimulated inflammatory gene expression in airway smooth muscle cells.
Halayko Andrew J, Unruh Helmut, Lontay Beata, Singer Cherie A, Gerthoffer William T   +4 more
doaj   +1 more source

Src Family Kinases and p38 Mitogen-Activated Protein Kinases Regulate Pluripotent Cell Differentiation in Culture. [PDF]

PLoS ONE, 2016
Multiple pluripotent cell populations, which together comprise the pluripotent cell lineage, have been identified. The mechanisms that control the progression between these populations are still poorly understood.
Boon Siang Nicholas Tan, Joly Kwek, Chong Kum Edwin Wong, Nicholas J Saner, Charlotte Yap, Fernando Felquer, Michael B Morris, David K Gardner, Peter D Rathjen, Joy Rathjen   +9 more
doaj   +1 more source

Recruitment of Lyn from endomembranes to the plasma membrane through calcium-dependent cell-cell interactions upon polarization of inducible Lyn-expressing MDCK cells

Scientific Reports, 2017
Src-family kinases, expressed in a wide variety of cell types, are anchored to cellular membranes through posttranslational lipid modifications and involved in diverse cellular signalling.
Takao Morinaga, Sayuri Yanase, Aya Okamoto, Noritaka Yamaguchi, Naoto Yamaguchi   +4 more
doaj   +1 more source

Ca²⁺ Signaling and Src Functions in Tumor Cells

Biomolecules, 2023
Signaling by calcium ion (Ca2+) plays a prominent role in cell physiology, and these mechanisms are frequently altered in tumor cells. In this review, we consider the interplay of Ca2+ signaling and the functions of the proto-oncogene non-receptor ...
Antonio Villalobo
doaj   +1 more source

Src-family tyrosine kinases and the Ca2+ signal

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017
In this review, we shall describe the rich crosstalk between non-receptor Src-family kinases (SFKs) and the Ca2+ transient generated in activated cells by a variety of extracellular and intracellular stimuli, resulting in diverse signaling events. The exchange of information between SFKs and Ca2+ is reciprocal, as it flows in both directions.
Anguita, Estefanía, Villalobo, Antonio
openaire   +3 more sources

Reengineering the Signaling Properties of a Src Family Kinase [PDF]

Biochemistry, 2009
Src family kinases (SFKs) are modular signaling proteins possessing SH3, SH2, and tyrosine kinase domains. The SH3 and SH2 domains of SFKs have dual roles: they regulate the activity of the kinases, and they also target SFKs to their cellular substrates. We generated a series of novel SFKs by replacing the SH2 and SH3 domains of Hck with the syntrophin
Shalini S, Yadav, Brian J, Yeh, Barbara P, Craddock, Wendell A, Lim, W Todd, Miller   +4 more
openaire   +2 more sources