Results 11 to 20 of about 80,567 (286)
Phosphorylation of Unique domains of Src family kinases [PDF]
Frontiers in Genetics, 2014 Members of the Src family of kinases (SFKs) are non-receptor tyrosine kinases involved innumerous signal transduction pathways. The catalytic, SH3 and SH2 domains are attached tothe membrane-anchoring SH4 domain through the intrinsically disordered ...
Irene eAmata +3 more
doaj +5 more sources
Src Family Kinases: A Potential Therapeutic Target for Acute Kidney Injury [PDF]
Biomolecules, 2022 Src family kinases (SFKs) are non-receptor tyrosine kinases and play a key role in regulating signal transduction. The mechanism of SFKs in various tumors has been widely studied, and there are more and more studies on its role in the kidney.
Nannan Li +8 more
doaj +4 more sources
Pharmacological inhibition of Src family kinases attenuates hyperuricemic nephropathy [PDF]
Frontiers in PharmacologyHyperuricemia is an independent risk factor for chronic kidney disease and contributes to renal fibrosis. This study aims to investigate the effect of Src family kinase (SFK) inhibition on the development of hyperuricemic nephropathy (HN) and the ...
Chongxiang Xiong +5 more
doaj +4 more sources
Src family kinases in chronic kidney disease. [PDF]
Am J Physiol Renal Physiol, 2017 Src family kinases (SFKs) belong to nonreceptor protein tyrosine kinases and have been implicated in the regulation of numerous cellular processes, including cell proliferation, differentiation, migration and invasion, and angiogenesis.
Wang J, Zhuang S.
europepmc +4 more sources
The Src-Family Kinases SRC and BLK Contribute to the CLDN6-Adhesion Signaling [PDF]
Cells, 2023 Cell adhesion molecules, including integrins, cadherins, and claudins (CLDNs), are known to activate Src-family kinases (SFKs) that organize a variety of physiological and pathological processes; however, the underlying molecular basis remains unclear ...
Naoki Ichikawa-Tomikawa +3 more
doaj +2 more sources
Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition [PDF]
Cell Communication and Signaling, 2021 Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement on SRC function. However, a significant body of work has defined Src family kinases as key players in tumor progression, invasion and metastasis in human ...
Maria A. Ortiz +5 more
doaj +2 more sources
Diverse Requirements for Src-Family Tyrosine Kinases Distinguish Chlamydial Species
mBio, 2011 Chlamydiae are well known for their species specificity and tissue tropism, and yet the individual species and strains show remarkable genomic synteny and share an intracellular developmental cycle unique in the microbial world.
Jeffrey Mital, Ted Hackstadt
doaj +2 more sources
Platelet Src family kinases: A tale of reversible phosphorylation [PDF]
Research and Practice in Thrombosis and Haemostasis, 2021 Sarcoma (Src) family kinases (SFKs) have occupied a central place in platelet research for over 40 years. Discovered by virologists and oncologists as the proto proto‐oncogene, Src tyrosine kinase spurred a phenomenal burst of research on reversible ...
Yotis A. Senis +4 more
doaj +2 more sources
Src family kinases engage differential pathways for encapsulation into extracellular vesicles [PDF]
Journal of Extracellular Biology, 2023 Extracellular vesicles (EVs) are heterogeneous biological nanoparticles secreted by all cell types. Identifying the proteins preferentially encapsulated in secreted EVs will help understand their heterogeneity.
Chenming Ye +10 more
doaj +2 more sources
Regulation of the Src Family Kinases by Csk [PDF]
International Journal of Biological Sciences, 2012 The non-receptor tyrosine kinase Csk serves as an indispensable negative regulator of the Src family tyrosine kinases (SFKs) by specifically phosphorylating the negative regulatory site of SFKs, thereby suppressing their oncogenic potential.
Masato Okada
doaj +3 more sources