Results 11 to 20 of about 112,254 (264)
Structural insights into redox-active cysteine residues of the Src family kinases [PDF]
Redox Biology, 2021 The Src Family Kinases (SFKs) are pivotal regulators of cellular signal transduction and highly sought-after targets in drug discovery. Their actions within cells are controlled by alterations in protein phosphorylation that switch the SFKs from ...
David E. Heppner
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Role of Src family kinases Fyn and Lyn in arenavirus infection [PDF]
Journal of VirologyArenaviruses encompass a diverse group of infectious agents, some of which, like Lassa virus (LASV), pose significant threats to global public health due to their acute virulence, while others, such as lymphocytic choriomeningitis virus (LCMV), are less ...
Wenting Mao +11 more
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Structure and regulation of Src family kinases [PDF]
Oncogene, 2004 Src family kinases are prototypical modular signaling proteins. Their conserved domain organization includes a myristoylated N-terminal segment followed by SH3, SH2, and tyrosine kinase domains, and a short C-terminal tail. Structural dissection of Src kinases has elucidated the canonical mechanisms of phosphotyrosine recognition by the SH2 domain and ...
Titus J, Boggon, Michael J, Eck
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Regulation of the Src Family Kinases by Csk [PDF]
International Journal of Biological Sciences, 2012 The non-receptor tyrosine kinase Csk serves as an indispensable negative regulator of the Src family tyrosine kinases (SFKs) by specifically phosphorylating the negative regulatory site of SFKs, thereby suppressing their oncogenic potential.
Masato Okada
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Src family kinases in chronic kidney disease. [PDF]
Am J Physiol Renal Physiol, 2017 Src family kinases (SFKs) belong to nonreceptor protein tyrosine kinases and have been implicated in the regulation of numerous cellular processes, including cell proliferation, differentiation, migration and invasion, and angiogenesis. The role and mechanisms of SFKs in tumorgenesis have been extensively investigated, and some SFK inhibitors are ...
Wang J, Zhuang S.
europepmc +3 more sources
Targeting SRC Family Kinases in Mesothelioma: Time to Upgrade. [PDF]
Cancers (Basel), 2020 Malignant mesothelioma (MM) is a deadly tumor mainly caused by exposure to asbestos. Unfortunately, no current treatment is able to change significantly the natural history of the disease, which has a poor prognosis in the majority of patients. The non-receptor tyrosine kinase SRC and other SRC family kinase (SFK) members are frequently hyperactivated ...
Indovina P +3 more
europepmc +6 more sources
Mindin regulates fibroblast subpopulations through distinct Src family kinases during fibrogenesis [PDF]
JCI InsightFibrosis results from excessive extracellular matrix (ECM) deposition, which causes tissue stiffening and organ dysfunction. Activated fibroblasts, central to fibrosis, exhibit increased migration, proliferation, contraction, and ECM production. However,
Sunny Kataria +14 more
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Src family kinases and pulmonary fibrosis: A review
Biomedicine & Pharmacotherapy, 2020 Src family kinases (SFKs) is a non-receptor protein tyrosine kinases family. They are crucial in signal transduction and regulation of various cell biological processes, such as proliferation, differentiation and apoptosis. The role and mechanism of SFKs in tumorigenesis have been widely studied. However, more and more studies have also shown that SFKs
Hang, Li +9 more
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Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance. [PDF]
PLoS ONE, 2019 Unregulated protein-tyrosine kinase signaling is a common feature of AML, often involving mutations in Flt3 and overexpression of myeloid Src-family kinases (Hck, Fgr, Lyn).
Ravi K Patel +5 more
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Myeloid Src-family kinases are critical for neutrophil-mediated autoinflammation in gout and motheaten models. [PDF]
J Exp Med, 2023 Futosi K +7 more
europepmc +2 more sources