Results 11 to 20 of about 61,468 (247)
Phosphorylation of Unique domains of Src family kinases [PDF]
Frontiers in Genetics, 2014 Members of the Src family of kinases (SFKs) are non-receptor tyrosine kinases involved innumerous signal transduction pathways. The catalytic, SH3 and SH2 domains are attached tothe membrane-anchoring SH4 domain through the intrinsically disordered ...
Irene eAmata +3 more
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Regulation of the Src Family Kinases by Csk [PDF]
International Journal of Biological Sciences, 2012 The non-receptor tyrosine kinase Csk serves as an indispensable negative regulator of the Src family tyrosine kinases (SFKs) by specifically phosphorylating the negative regulatory site of SFKs, thereby suppressing their oncogenic potential.
Masato Okada
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Myeloid Src-family kinases are critical for neutrophil-mediated autoinflammation in gout and motheaten models [PDF]
Journal of Experimental Medicine, 2023 Tamás Nemeth +2 more
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Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications [PDF]
Cancers, 2020 Wook Jin, Jin Wook
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Src family kinases and paclitaxel sensitivity [PDF]
Cancer Biology & Therapy, 2011 Src-family Kinases (SFKs) participate in the regulation of proliferation, differentiation, apoptosis, autophagy, adhesion, migration, invasion and angiogenesis in normal and cancer cells. Abnormal expression of SFKs has been documented in cancers that arise in breast, colon, ovary, melanocyte, gastric mucosa, head and neck, pancreas, lung, and brain ...
Xiao-Feng, Le, Robert C, Bast
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Structure and regulation of Src family kinases [PDF]
Oncogene, 2004 Src family kinases are prototypical modular signaling proteins. Their conserved domain organization includes a myristoylated N-terminal segment followed by SH3, SH2, and tyrosine kinase domains, and a short C-terminal tail. Structural dissection of Src kinases has elucidated the canonical mechanisms of phosphotyrosine recognition by the SH2 domain and ...
Titus J, Boggon, Michael J, Eck
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Src Family Kinases as Therapeutic Targets in Advanced Solid Tumors: What We Have Learned So Far [PDF]
Cancers, 2020 Lorenzo Botta +2 more
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The tyrosine kinase Csk dimerizes through Its SH3 domain. [PDF]
PLoS ONE, 2009 The Src family kinases possess two sites of tyrosine phosphorylation that are critical to the regulation of kinase activity. Autophosphorylation on an activation loop tyrosine residue (Tyr 416 in commonly used chicken c-Src numbering) increases catalytic
Nicholas M Levinson +2 more
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The Role of Src Family Kinases in Neuroendocrine Tumors [PDF]
Gastroenterology, 2012 [No abstract available]
Capurso, G +2 more
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Regulation of Fibroblast Cell Polarity by Src Tyrosine Kinase
Biomedicines, 2021 Src protein tyrosine kinases (SFKs) are a family of nonreceptor tyrosine kinases that are localized beneath the plasma membrane and are activated during cell adhesion, migration, and elongation.
Kazuo Katoh
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