Results 21 to 30 of about 80,567 (286)

Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes [PDF]

Frontiers in Immunology, 2017
In a synthetic biology approach using Schneider (S2) cells, we show that SLP-76 is directly phosphorylated at tyrosines Y113 and Y128 by SYK in the presence of ITAM-containing adapters such as CD3ζ, DAP12, or FcεRγ.
Frank Fasbender, Maren Claus, Sabine Wingert, Mina Sandusky, Carsten Watzl   +4 more
doaj   +2 more sources

Tau and src family tyrosine kinases

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2004
The interaction between tau and src family non-receptor tyrosine kinases represents a new function for tau. Mediated by the proline-rich region of tau and the SH3 domain of fyn or src, this interaction has the potential to confer novel cellular ...
Gloria Lee, Lee, Gloria
core   +3 more sources

Regulation of Src Family Kinases in Human Cancers [PDF]

Journal of Signal Transduction, 2011
The nonreceptor protein tyrosine kinase Src plays a crucial role in the signal transduction pathways involved in cell division, motility, adhesion, and survival in both normal and cancer cells.
Faye M. Johnson, Banibrata Sen
core   +3 more sources

Src Family Kinases Inhibition Ameliorates Hypoxic-Ischemic Brain Injury in Immature Rats [PDF]

Frontiers in Cellular Neuroscience, 2021
Hypoxic-ischemic (HI) injury is one of the initial factors contributing to neonatal brain injury. Src family kinases (SFKs) are considered to act as molecular hubs for N-methyl-d-aspartate receptor (NMDAR) regulation and participate in the HI injury ...
Han Qiu, Tianyang Qian, Tong Wu, Ting Gao, Qinghe Xing, Laishuan Wang   +5 more
doaj   +2 more sources

Role of Src family kinases Fyn and Lyn in arenavirus infection [PDF]

Journal of Virology
Arenaviruses encompass a diverse group of infectious agents, some of which, like Lassa virus (LASV), pose significant threats to global public health due to their acute virulence, while others, such as lymphocytic choriomeningitis virus (LCMV), are less ...
Wenting Mao, Minmin Zhou, Cheng Peng, Yi Wan, Li Li, Jialing Hu, Yang Liu, Yuan Peng, Chao Shan, Fei Deng, Zhiming Yuan, Wei Wang   +11 more
doaj   +2 more sources

Structural insights into redox-active cysteine residues of the Src family kinases [PDF]

Redox Biology, 2021
The Src Family Kinases (SFKs) are pivotal regulators of cellular signal transduction and highly sought-after targets in drug discovery. Their actions within cells are controlled by alterations in protein phosphorylation that switch the SFKs from ...
David E. Heppner
doaj   +2 more sources

Targeting SRC Family Kinases in Mesothelioma: Time to Upgrade. [PDF]

Cancers (Basel), 2020
Malignant mesothelioma (MM) is a deadly tumor mainly caused by exposure to asbestos. Unfortunately, no current treatment is able to change significantly the natural history of the disease, which has a poor prognosis in the majority of patients. The non-receptor tyrosine kinase SRC and other SRC family kinase (SFK) members are frequently hyperactivated ...
Indovina P, Forte IM, Pentimalli F, Giordano A.   +3 more
europepmc   +6 more sources

Src family kinases and pulmonary fibrosis: A review

Biomedicine and Pharmacotherapy, 2020
Src family kinases (SFKs) is a non-receptor protein tyrosine kinases family. They are crucial in signal transduction and regulation of various cell biological processes, such as proliferation, differentiation and apoptosis. The role and mechanism of SFKs in tumorigenesis have been widely studied. However, more and more studies have also shown that SFKs
Hang Li, Caiping Zhao, Guiyu Zhang
exaly   +3 more sources

The interplay between Src family kinases and receptor tyrosine kinases. [PDF]

Oncogene, 2004
Src family tyrosine kinases (SFKs) are involved in a diverse array of physiological processes, as highlighted in this review. An overview of how SFKs interact with, and participate in signaling from, receptor tyrosine kinases (RTKs) is discussed.
Courtneidge, Sara A., Sara A Courtneidge, Korkaya, Hasan, Paul A Bromann, Bromann, Paul Andrew, Hasan Korkaya   +5 more
core   +3 more sources

Src Family Kinases and p38 Mitogen-Activated Protein Kinases Regulate Pluripotent Cell Differentiation in Culture. [PDF]

PLoS ONE, 2016
Multiple pluripotent cell populations, which together comprise the pluripotent cell lineage, have been identified. The mechanisms that control the progression between these populations are still poorly understood.
Boon Siang Nicholas Tan, Joly Kwek, Chong Kum Edwin Wong, Nicholas J Saner, Charlotte Yap, Fernando Felquer, Michael B Morris, David K Gardner, Peter D Rathjen, Joy Rathjen   +9 more
doaj   +3 more sources