Results 21 to 30 of about 112,254 (264)

Src Dependent Pancreatic Acinar Injury Can Be Initiated Independent of an Increase in Cytosolic Calcium [PDF]

, 2013
Several deleterious intra-acinar phenomena are simultaneously triggered on initiating acute pancreatitis. These culminate in acinar injury or inflammatory mediator generation in vitro and parenchymal damage in vivo. Supraphysiologic caerulein is one such
A Gnoni, A Pace, A Sharma, AJ Hietaranta, AK Saluja, AK Saluja, AS Gukovskaya, B Han, B Han, B Hofbauer, B Kruger, C Schafer, Catherine J. Baty, CH Kubisch, Chandra Durgampudi, Chathur Acharya, DN Criddle, Donna B. Stolz, EC Thrower, EM Parker, F Gorelick, F Mooren, F Nozu, G Lynch, H Weber, HK Baumgartner, I Gukovsky, I Gukovsky, I Samuel, JA Tapia, JA Williams, Jenny Karlsson, JV Gerasimenko, KA Muili, Krutika Patel, L Fischer, L Orlichenko, Lidiya Orlichenko, LJ Christopher, LJ Lombardo, LS Orlichenko, M Sendler, MS O'Konski, OA Mareninova, OH Petersen, Pawan Noel, PC Redondo, Rachel Cline, Ram Narayan Trivedi, RD Duan, RR Torgerson, RR Torgerson, S Kawabata, S Navina, Sarah Navina, SD Waterford, SG Weller, SJ Pandol, Sohail Z. Husain, Stuart E. Dryer, SZ Husain, SZ Husain, T Eley, T Grady, T Grady, V Sancho, Vijay P. Singh, Vivek Mishra, VP Singh, VP Singh, VP Singh, VP Singh, Y Tsunoda   +72 more
core   +17 more sources

The tyrosine kinase Csk dimerizes through Its SH3 domain. [PDF]

PLoS ONE, 2009
The Src family kinases possess two sites of tyrosine phosphorylation that are critical to the regulation of kinase activity. Autophosphorylation on an activation loop tyrosine residue (Tyr 416 in commonly used chicken c-Src numbering) increases catalytic
Nicholas M Levinson, Patrick R Visperas, John Kuriyan   +2 more
doaj   +1 more source

Src family kinases and paclitaxel sensitivity [PDF]

Cancer Biology & Therapy, 2011
Src-family Kinases (SFKs) participate in the regulation of proliferation, differentiation, apoptosis, autophagy, adhesion, migration, invasion and angiogenesis in normal and cancer cells. Abnormal expression of SFKs has been documented in cancers that arise in breast, colon, ovary, melanocyte, gastric mucosa, head and neck, pancreas, lung, and brain ...
Xiao-Feng, Le, Robert C, Bast
openaire   +2 more sources

Regulation of Fibroblast Cell Polarity by Src Tyrosine Kinase

Biomedicines, 2021
Src protein tyrosine kinases (SFKs) are a family of nonreceptor tyrosine kinases that are localized beneath the plasma membrane and are activated during cell adhesion, migration, and elongation.
Kazuo Katoh
doaj   +1 more source

Diverse Requirements for Src-Family Tyrosine Kinases Distinguish Chlamydial Species

mBio, 2011
Chlamydiae are well known for their species specificity and tissue tropism, and yet the individual species and strains show remarkable genomic synteny and share an intracellular developmental cycle unique in the microbial world.
Jeffrey Mital, Ted Hackstadt
doaj   +1 more source

Different roles for non-receptor tyrosine kinases in arachidonate release induced by zymosan and Staphylococcus aureus in macrophages

Journal of Inflammation, 2006
Background Yeast and bacteria elicit arachidonate release in macrophages, leading to the formation of leukotrienes and prostaglandins, important mediators of inflammation.
Sundler Roger, Olsson Sandra
doaj   +1 more source

Targeting Src family kinases inhibits bevacizumab-induced glioma cell invasion. [PDF]

PLoS ONE, 2013
Anti-VEGF antibody therapy with bevacizumab provides significant clinical benefit in patients with recurrent glioblastoma multiforme (GBM). Unfortunately, progression on bevacizumab therapy is often associated with a diffuse disease recurrence pattern ...
Deborah Huveldt, Laura J Lewis-Tuffin, Brett L Carlson, Mark A Schroeder, Fausto Rodriguez, Caterina Giannini, Evanthia Galanis, Jann N Sarkaria, Panos Z Anastasiadis   +8 more
doaj   +1 more source

c-Src drives intestinal regeneration and transformation [PDF]

, 2014
The non‐receptor tyrosine kinase c‐Src, hereafter referred to as Src, is overexpressed or activated in multiple human malignancies. There has been much speculation about the functional role of Src in colorectal cancer (CRC), with Src amplification and ...
Cordero, Julia B., Frame, Margaret, Muller, William J., Nixon, Colin, Ridgway, Rachel A., Sansom, Owen J., Valeri, Nicola, Vidal, Marcos   +7 more
core   +3 more sources

Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk

BMC Immunology, 2001
Background The Tec family kinases are implicated in signaling from lymphocyte antigen receptors and are activated following phosphorylation by Src kinases.
Debnath Jayanta, Czar Michael J, Chamorro Mario, Cheng Genhong, Lenardo Michael J, Varmus Harold E, Schwartzberg Pamela L   +6 more
doaj   +1 more source

Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes

Frontiers in Immunology, 2017
In a synthetic biology approach using Schneider (S2) cells, we show that SLP-76 is directly phosphorylated at tyrosines Y113 and Y128 by SYK in the presence of ITAM-containing adapters such as CD3ζ, DAP12, or FcεRγ.
Frank Fasbender, Maren Claus, Sabine Wingert, Mina Sandusky, Carsten Watzl   +4 more
doaj   +1 more source