Results 21 to 30 of about 61,468 (247)
Targeting SRC Family Kinases in Mesothelioma: Time to Upgrade. [PDF]
Cancers (Basel), 2020 Malignant mesothelioma (MM) is a deadly tumor mainly caused by exposure to asbestos. Unfortunately, no current treatment is able to change significantly the natural history of the disease, which has a poor prognosis in the majority of patients. The non-receptor tyrosine kinase SRC and other SRC family kinase (SFK) members are frequently hyperactivated ...
Indovina P +3 more
europepmc +6 more sources
Diverse Requirements for Src-Family Tyrosine Kinases Distinguish Chlamydial Species
mBio, 2011 Chlamydiae are well known for their species specificity and tissue tropism, and yet the individual species and strains show remarkable genomic synteny and share an intracellular developmental cycle unique in the microbial world.
Jeffrey Mital, Ted Hackstadt
doaj +1 more source
Journal of Inflammation, 2006 Background Yeast and bacteria elicit arachidonate release in macrophages, leading to the formation of leukotrienes and prostaglandins, important mediators of inflammation.
Sundler Roger, Olsson Sandra
doaj +1 more source
Targeting Src family kinases inhibits bevacizumab-induced glioma cell invasion. [PDF]
PLoS ONE, 2013 Anti-VEGF antibody therapy with bevacizumab provides significant clinical benefit in patients with recurrent glioblastoma multiforme (GBM). Unfortunately, progression on bevacizumab therapy is often associated with a diffuse disease recurrence pattern ...
Deborah Huveldt +8 more
doaj +1 more source
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk
BMC Immunology, 2001 Background The Tec family kinases are implicated in signaling from lymphocyte antigen receptors and are activated following phosphorylation by Src kinases.
Debnath Jayanta +6 more
doaj +1 more source
Frontiers in Immunology, 2017 In a synthetic biology approach using Schneider (S2) cells, we show that SLP-76 is directly phosphorylated at tyrosines Y113 and Y128 by SYK in the presence of ITAM-containing adapters such as CD3ζ, DAP12, or FcεRγ.
Frank Fasbender +4 more
doaj +1 more source
Regulation of Src Family Kinases in Human Cancers [PDF]
Journal of Signal Transduction, 2011 The nonreceptor protein tyrosine kinase Src plays a crucial role in the signal transduction pathways involved in cell division, motility, adhesion, and survival in both normal and cancer cells. Although the Src family kinases (SFKs) are activated in various types of cancers, the exact mechanisms through which they contribute to the progression of ...
Sen, Banibrata, Johnson, Faye M.
openaire +2 more sources
Regulation of Btk by Src Family Tyrosine Kinases [PDF]
Molecular and Cellular Biology, 1996 Loss of function of Bruton's tyrosine kinase (Btk) results in X-linked immunodeficiencies characterized by a broad spectrum of signaling defects, including those dependent on Src family kinase-linked cell surface receptors. A gain-of-function mutant, Btk*, induces the growth of fibroblasts in soft agar and relieves the interleukin-5 dependence of a pre-
D E, Afar +5 more
openaire +2 more sources
Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells. [PDF]
PLoS ONE, 2010 Receptor tyrosine kinases (RTKs) activate multiple downstream cytosolic tyrosine kinases following ligand stimulation. SRC family kinases (SFKs), which are recruited to activated RTKs through SH2 domain interactions with RTK autophosphorylation sites ...
Melodie L Knowlton +7 more
doaj +1 more source
Src kinases are required for a balanced production of IL-12/IL-23 in human dendritic cells activated by Toll-like receptor agonists. [PDF]
PLoS ONE, 2010 BACKGROUND: Pathogen recognition by dendritic cells (DC) is crucial for the initiation of both innate and adaptive immune responses. Activation of Toll-like Receptors (TLRs) by microbial molecular patterns leads to the maturation of DC, which present the
Mirela Kuka +7 more
doaj +1 more source