Results 41 to 50 of about 80,567 (286)

Different roles for non-receptor tyrosine kinases in arachidonate release induced by zymosan and Staphylococcus aureus in macrophages

Journal of Inflammation, 2006
Background Yeast and bacteria elicit arachidonate release in macrophages, leading to the formation of leukotrienes and prostaglandins, important mediators of inflammation.
Sundler Roger, Olsson Sandra
doaj   +1 more source

Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk

BMC Immunology, 2001
Background The Tec family kinases are implicated in signaling from lymphocyte antigen receptors and are activated following phosphorylation by Src kinases.
Debnath Jayanta, Czar Michael J, Chamorro Mario, Cheng Genhong, Lenardo Michael J, Varmus Harold E, Schwartzberg Pamela L   +6 more
doaj   +1 more source

Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells. [PDF]

PLoS ONE, 2010
Receptor tyrosine kinases (RTKs) activate multiple downstream cytosolic tyrosine kinases following ligand stimulation. SRC family kinases (SFKs), which are recruited to activated RTKs through SH2 domain interactions with RTK autophosphorylation sites ...
Melodie L Knowlton, Laura M Selfors, Carolyn N Wrobel, Ting-Lei Gu, Bryan A Ballif, Steven P Gygi, Roberto Polakiewicz, Joan S Brugge   +7 more
doaj   +1 more source

Phylogeny of Tec Family Kinases: Identification of a Pre-Metazoan Origin of Btk, Bmx, Itk, Tec, Txk and the Btk Regulator SH3BP5 [PDF]

, 2008
It is generally considered mammals and birds have five Tec family kinases (TFKs): Btk, Bmx (also known as Etk), Itk, Tec, and Txk (also known as Rlk). Here, we discuss the domains and their functions and regulation in TFKs.
Ortutay, Csaba, Beston F. Nore, Nore, Beston F., Vihinen, Mauno, C.I. Edvard Smith, Smith, C. I. Edvard, Csaba Ortutay, Mauno Vihinen   +7 more
core   +1 more source

Regulation of Btk by Src Family Tyrosine Kinases [PDF]

Molecular and Cellular Biology, 1996
Loss of function of Bruton's tyrosine kinase (Btk) results in X-linked immunodeficiencies characterized by a broad spectrum of signaling defects, including those dependent on Src family kinase-linked cell surface receptors. A gain-of-function mutant, Btk*, induces the growth of fibroblasts in soft agar and relieves the interleukin-5 dependence of a pre-
D E, Afar, H, Park, B W, Howell, D J, Rawlings, J, Cooper, O N, Witte   +5 more
openaire   +2 more sources

Src kinases are required for a balanced production of IL-12/IL-23 in human dendritic cells activated by Toll-like receptor agonists. [PDF]

PLoS ONE, 2010
BACKGROUND: Pathogen recognition by dendritic cells (DC) is crucial for the initiation of both innate and adaptive immune responses. Activation of Toll-like Receptors (TLRs) by microbial molecular patterns leads to the maturation of DC, which present the
Mirela Kuka, Roberta Baronio, Sara Valentini, Elisabetta Monaci, Alessandro Muzzi, Susanna Aprea, Ennio De Gregorio, Ugo D'Oro   +7 more
doaj   +1 more source

Phosphorylated c-Src in the nucleus is associated with improved patient outcome in ER-positive breast cancer [PDF]

, 2008
Elevated c-Src protein expression has been shown in breast cancer and <i>in vitro</i> evidence suggests a role in endocrine resistance. To investigate whether c-Src is involved in endocrine resistance, we examined the expression of both total
Cooke, T.G., Tatarov, O., Tovey, S, O Tatarov, V Brunton, T G Cooke, McDuff, E, E J Campbell, McDuff, E., Tovey, S., Edwards, J, E McDuff, Brunton, V.G., S Tovey, Brunton, V, J Edwards, Edwards, J., Campbell, E J, Tatarov, O, Campbell, E.J., Cooke, T G   +20 more
core   +1 more source

Characterization of Novel Src Family Kinase Inhibitors to Attenuate Microgliosis. [PDF]

PLoS ONE, 2015
Microgliosis is a major hallmark of Alzheimer's disease (AD) brain pathology. Aβ peptide is hypothesized to act as a stimulus for microglia leading to activation of non-receptor tyrosine kinases and subsequent secretion of pro-inflammatory cytokines ...
Gunjan D Manocha, Kendra L Puig, Susan A Austin, Kathleen Seyb, Marcie A Glicksman, Colin K Combs   +5 more
doaj   +1 more source

Src-family kinases activation in spinal microglia contributes to central sensitization and chronic pain after lumbar disc herniation

Molecular Pain, 2017
Background Lumbar disc herniation is a major cause of radicular pain, but the underlying mechanisms remain largely unknown. Spinal activation of src-family kinases are involved in the development of chronic pain from nerve injury, inflammation, and ...
Yangliang Huang, Yongyong Li, Xiongxiong Zhong, Yuming Hu, Pan Liu, Yuanshu Zhao, Zhen Deng, Xianguo Liu, Shaoyu Liu, Yi Zhong   +9 more
doaj   +1 more source

The diverse functions of Src family kinases in macrophages [PDF]

Frontiers in Bioscience, 2008
Macrophages are key components of the innate immune response. These cells possess a diverse repertoire of receptors that allow them to respond to a host of external stimuli including cytokines, chemokines, and pathogen-associated molecules. Signals resulting from these stimuli activate a number of macrophage functional responses such as adhesion ...
Clare L, Abram, Clifford A, Lowell
openaire   +2 more sources