Results 51 to 60 of about 80,567 (286)
The Src family kinases: distinct functions of c-Src, Yes, and Fyn in the liver
Biomolecular Concepts, 2013 The Src family kinases Yes, Fyn, and c-Src play a pivotal role in regulating diverse liver functions such as bile flow, proteolysis, apoptosis, and proliferation and are regulated by anisoosmotic cell volume changes, death receptor ligands, and bile ...
Reinehr Roland +2 more
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Ca2+ Signaling and Src Functions in Tumor Cells
Biomolecules, 2023 Signaling by calcium ion (Ca2+) plays a prominent role in cell physiology, and these mechanisms are frequently altered in tumor cells. In this review, we consider the interplay of Ca2+ signaling and the functions of the proto-oncogene non-receptor ...
Antonio Villalobo
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Reengineering the Signaling Properties of a Src Family Kinase [PDF]
Biochemistry, 2009 Src family kinases (SFKs) are modular signaling proteins possessing SH3, SH2, and tyrosine kinase domains. The SH3 and SH2 domains of SFKs have dual roles: they regulate the activity of the kinases, and they also target SFKs to their cellular substrates. We generated a series of novel SFKs by replacing the SH2 and SH3 domains of Hck with the syntrophin
Shalini S, Yadav +4 more
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Scientific Reports, 2017 Src-family kinases, expressed in a wide variety of cell types, are anchored to cellular membranes through posttranslational lipid modifications and involved in diverse cellular signalling.
Takao Morinaga +4 more
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Src mediates cytokine-stimulated gene expression in airway myocytes through ERK MAPK
Cell Communication and Signaling, 2011 The p38 and extracellular signal-regulated kinases (ERK) mitogen-activated protein kinases (MAPK) participate in cytokine-stimulated inflammatory gene expression in airway smooth muscle cells.
Halayko Andrew J +4 more
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Src-family tyrosine kinases and the Ca2+ signal
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017 In this review, we shall describe the rich crosstalk between non-receptor Src-family kinases (SFKs) and the Ca2+ transient generated in activated cells by a variety of extracellular and intracellular stimuli, resulting in diverse signaling events. The exchange of information between SFKs and Ca2+ is reciprocal, as it flows in both directions.
Anguita, Estefanía, Villalobo, Antonio
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B cell activation triggered by the formation of the small receptor cluster: a computational study. [PDF]
PLoS Computational Biology, 2011 We proposed a spatially extended model of early events of B cell receptors (BCR) activation, which is based on mutual kinase-receptor interactions that are characteristic for the immune receptors and the Src family kinases. These interactions lead to the
Beata Hat +2 more
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Src family kinases: at the forefront of platelet activation [PDF]
Blood, 2014 AbstractSrc family kinases (SFKs) play a central role in mediating the rapid response of platelets to vascular injury. They transmit activation signals from a diverse repertoire of platelet surface receptors, including the integrin αIIbβ3, the immunoreceptor tyrosine–based activation motif–containing collagen receptor complex GPVI-FcR γ-chain, and the ...
Yotis A, Senis +2 more
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SRC: A Century of Science Brought to the Clinic
Neoplasia: An International Journal for Oncology Research, 2010 The SRC family kinases are the largest family of norreceptor tyrosine kinases and one of the best-studied targets for cancer therapy. SRC, arguably the oldest oncogene, has been implicated in pathways regulating proliferation, angiogenesis, invasion and ...
Alexey Aleshin, Richard S. Finn
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Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner. [PDF]
PLoS ONE, 2012 The HIV-1 accessory factor Nef is essential for high-titer viral replication and AIDS progression. Nef function requires interaction with many host cell proteins, including specific members of the Src kinase family.
Purushottam S Narute, Thomas E Smithgall
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