Results 31 to 40 of about 61,368 (147)

Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells. [PDF]

PLoS ONE, 2010
Receptor tyrosine kinases (RTKs) activate multiple downstream cytosolic tyrosine kinases following ligand stimulation. SRC family kinases (SFKs), which are recruited to activated RTKs through SH2 domain interactions with RTK autophosphorylation sites ...
Melodie L Knowlton, Laura M Selfors, Carolyn N Wrobel, Ting-Lei Gu, Bryan A Ballif, Steven P Gygi, Roberto Polakiewicz, Joan S Brugge   +7 more
doaj   +1 more source

Src kinases are required for a balanced production of IL-12/IL-23 in human dendritic cells activated by Toll-like receptor agonists. [PDF]

PLoS ONE, 2010
BACKGROUND: Pathogen recognition by dendritic cells (DC) is crucial for the initiation of both innate and adaptive immune responses. Activation of Toll-like Receptors (TLRs) by microbial molecular patterns leads to the maturation of DC, which present the
Mirela Kuka, Roberta Baronio, Sara Valentini, Elisabetta Monaci, Alessandro Muzzi, Susanna Aprea, Ennio De Gregorio, Ugo D'Oro   +7 more
doaj   +1 more source

Characterization of Novel Src Family Kinase Inhibitors to Attenuate Microgliosis. [PDF]

PLoS ONE, 2015
Microgliosis is a major hallmark of Alzheimer's disease (AD) brain pathology. Aβ peptide is hypothesized to act as a stimulus for microglia leading to activation of non-receptor tyrosine kinases and subsequent secretion of pro-inflammatory cytokines ...
Gunjan D Manocha, Kendra L Puig, Susan A Austin, Kathleen Seyb, Marcie A Glicksman, Colin K Combs   +5 more
doaj   +1 more source

Src-family kinases activation in spinal microglia contributes to central sensitization and chronic pain after lumbar disc herniation

Molecular Pain, 2017
Background Lumbar disc herniation is a major cause of radicular pain, but the underlying mechanisms remain largely unknown. Spinal activation of src-family kinases are involved in the development of chronic pain from nerve injury, inflammation, and ...
Yangliang Huang, Yongyong Li, Xiongxiong Zhong, Yuming Hu, Pan Liu, Yuanshu Zhao, Zhen Deng, Xianguo Liu, Shaoyu Liu, Yi Zhong   +9 more
doaj   +1 more source

The diverse functions of Src family kinases in macrophages [PDF]

Frontiers in Bioscience, 2008
Macrophages are key components of the innate immune response. These cells possess a diverse repertoire of receptors that allow them to respond to a host of external stimuli including cytokines, chemokines, and pathogen-associated molecules. Signals resulting from these stimuli activate a number of macrophage functional responses such as adhesion ...
Clare L, Abram, Clifford A, Lowell
openaire   +2 more sources

The Src family kinases: distinct functions of c-Src, Yes, and Fyn in the liver

Biomolecular Concepts, 2013
The Src family kinases Yes, Fyn, and c-Src play a pivotal role in regulating diverse liver functions such as bile flow, proteolysis, apoptosis, and proliferation and are regulated by anisoosmotic cell volume changes, death receptor ligands, and bile ...
Reinehr Roland, Sommerfeld Annika, Häussinger Dieter   +2 more
doaj   +1 more source

Src mediates cytokine-stimulated gene expression in airway myocytes through ERK MAPK

Cell Communication and Signaling, 2011
The p38 and extracellular signal-regulated kinases (ERK) mitogen-activated protein kinases (MAPK) participate in cytokine-stimulated inflammatory gene expression in airway smooth muscle cells.
Halayko Andrew J, Unruh Helmut, Lontay Beata, Singer Cherie A, Gerthoffer William T   +4 more
doaj   +1 more source

Src Family Kinases and p38 Mitogen-Activated Protein Kinases Regulate Pluripotent Cell Differentiation in Culture. [PDF]

PLoS ONE, 2016
Multiple pluripotent cell populations, which together comprise the pluripotent cell lineage, have been identified. The mechanisms that control the progression between these populations are still poorly understood.
Boon Siang Nicholas Tan, Joly Kwek, Chong Kum Edwin Wong, Nicholas J Saner, Charlotte Yap, Fernando Felquer, Michael B Morris, David K Gardner, Peter D Rathjen, Joy Rathjen   +9 more
doaj   +1 more source

Recruitment of Lyn from endomembranes to the plasma membrane through calcium-dependent cell-cell interactions upon polarization of inducible Lyn-expressing MDCK cells

Scientific Reports, 2017
Src-family kinases, expressed in a wide variety of cell types, are anchored to cellular membranes through posttranslational lipid modifications and involved in diverse cellular signalling.
Takao Morinaga, Sayuri Yanase, Aya Okamoto, Noritaka Yamaguchi, Naoto Yamaguchi   +4 more
doaj   +1 more source

Ca²⁺ Signaling and Src Functions in Tumor Cells

Biomolecules, 2023
Signaling by calcium ion (Ca2+) plays a prominent role in cell physiology, and these mechanisms are frequently altered in tumor cells. In this review, we consider the interplay of Ca2+ signaling and the functions of the proto-oncogene non-receptor ...
Antonio Villalobo
doaj   +1 more source