Results 31 to 40 of about 64,838 (284)
Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications [PDF]
Cancers, 2020 Wook Jin
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Src family kinases and paclitaxel sensitivity [PDF]
Cancer Biology & Therapy, 2011 Src-family Kinases (SFKs) participate in the regulation of proliferation, differentiation, apoptosis, autophagy, adhesion, migration, invasion and angiogenesis in normal and cancer cells. Abnormal expression of SFKs has been documented in cancers that arise in breast, colon, ovary, melanocyte, gastric mucosa, head and neck, pancreas, lung, and brain ...
Xiao-Feng, Le, Robert C, Bast
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Structure and regulation of Src family kinases [PDF]
Oncogene, 2004 Src family kinases are prototypical modular signaling proteins. Their conserved domain organization includes a myristoylated N-terminal segment followed by SH3, SH2, and tyrosine kinase domains, and a short C-terminal tail. Structural dissection of Src kinases has elucidated the canonical mechanisms of phosphotyrosine recognition by the SH2 domain and ...
Titus J, Boggon, Michael J, Eck
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Src Family Kinases as Therapeutic Targets in Advanced Solid Tumors: What We Have Learned So Far [PDF]
Cancers, 2020 Stefano Martellucci +2 more
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The tyrosine kinase Csk dimerizes through Its SH3 domain. [PDF]
PLoS ONE, 2009 The Src family kinases possess two sites of tyrosine phosphorylation that are critical to the regulation of kinase activity. Autophosphorylation on an activation loop tyrosine residue (Tyr 416 in commonly used chicken c-Src numbering) increases catalytic
Nicholas M Levinson +2 more
doaj +1 more source
Regulation of Fibroblast Cell Polarity by Src Tyrosine Kinase
Biomedicines, 2021 Src protein tyrosine kinases (SFKs) are a family of nonreceptor tyrosine kinases that are localized beneath the plasma membrane and are activated during cell adhesion, migration, and elongation.
Kazuo Katoh
doaj +1 more source
Targeting SRC Family Kinases in Mesothelioma: Time to Upgrade. [PDF]
Cancers (Basel), 2020 Malignant mesothelioma (MM) is a deadly tumor mainly caused by exposure to asbestos. Unfortunately, no current treatment is able to change significantly the natural history of the disease, which has a poor prognosis in the majority of patients. The non-receptor tyrosine kinase SRC and other SRC family kinase (SFK) members are frequently hyperactivated ...
Indovina P +3 more
europepmc +6 more sources
The Role of Src Family Kinases in Neuroendocrine Tumors [PDF]
Gastroenterology, 2012 [No abstract available]
Capurso, G +2 more
openaire +5 more sources
Regulation of Btk by Src Family Tyrosine Kinases [PDF]
Molecular and Cellular Biology, 1996 Loss of function of Bruton's tyrosine kinase (Btk) results in X-linked immunodeficiencies characterized by a broad spectrum of signaling defects, including those dependent on Src family kinase-linked cell surface receptors. A gain-of-function mutant, Btk*, induces the growth of fibroblasts in soft agar and relieves the interleukin-5 dependence of a pre-
D E, Afar +5 more
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The diverse functions of Src family kinases in macrophages [PDF]
Frontiers in Bioscience, 2008 Macrophages are key components of the innate immune response. These cells possess a diverse repertoire of receptors that allow them to respond to a host of external stimuli including cytokines, chemokines, and pathogen-associated molecules. Signals resulting from these stimuli activate a number of macrophage functional responses such as adhesion ...
Clare L, Abram, Clifford A, Lowell
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