Src Family Kinases Inhibition Ameliorates Hypoxic-Ischemic Brain Injury in Immature Rats [PDF]
Frontiers in Cellular Neuroscience, 2021 Hypoxic-ischemic (HI) injury is one of the initial factors contributing to neonatal brain injury. Src family kinases (SFKs) are considered to act as molecular hubs for N-methyl-d-aspartate receptor (NMDAR) regulation and participate in the HI injury ...
Han Qiu +5 more
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Role of Src family kinases Fyn and Lyn in arenavirus infection [PDF]
Journal of VirologyArenaviruses encompass a diverse group of infectious agents, some of which, like Lassa virus (LASV), pose significant threats to global public health due to their acute virulence, while others, such as lymphocytic choriomeningitis virus (LCMV), are less ...
Wenting Mao +11 more
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Structural insights into redox-active cysteine residues of the Src family kinases [PDF]
Redox Biology, 2021 The Src Family Kinases (SFKs) are pivotal regulators of cellular signal transduction and highly sought-after targets in drug discovery. Their actions within cells are controlled by alterations in protein phosphorylation that switch the SFKs from ...
David E. Heppner
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Tau and src family tyrosine kinases
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2004 The interaction between tau and src family non-receptor tyrosine kinases represents a new function for tau. Mediated by the proline-rich region of tau and the SH3 domain of fyn or src, this interaction has the potential to confer novel cellular ...
Gloria Lee, Lee, Gloria
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Regulation of Src Family Kinases in Human Cancers [PDF]
Journal of Signal Transduction, 2011 The nonreceptor protein tyrosine kinase Src plays a crucial role in the signal transduction pathways involved in cell division, motility, adhesion, and survival in both normal and cancer cells.
Faye M. Johnson, Banibrata Sen
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Regulation of the Src Family Kinases by Csk [PDF]
International Journal of Biological Sciences, 2012 The non-receptor tyrosine kinase Csk serves as an indispensable negative regulator of the Src family tyrosine kinases (SFKs) by specifically phosphorylating the negative regulatory site of SFKs, thereby suppressing their oncogenic potential.
Masato Okada
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Src Family Kinases and p38 Mitogen-Activated Protein Kinases Regulate Pluripotent Cell Differentiation in Culture. [PDF]
PLoS ONE, 2016 Multiple pluripotent cell populations, which together comprise the pluripotent cell lineage, have been identified. The mechanisms that control the progression between these populations are still poorly understood.
Boon Siang Nicholas Tan +9 more
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Mindin regulates fibroblast subpopulations through distinct Src family kinases during fibrogenesis [PDF]
JCI InsightFibrosis results from excessive extracellular matrix (ECM) deposition, which causes tissue stiffening and organ dysfunction. Activated fibroblasts, central to fibrosis, exhibit increased migration, proliferation, contraction, and ECM production. However,
Sunny Kataria +14 more
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Myeloid Src-family kinases are critical for neutrophil-mediated autoinflammation in gout and motheaten models [PDF]
Journal of Experimental Medicine, 2023 Krisztina Futosi +2 more
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The interplay between Src family kinases and receptor tyrosine kinases. [PDF]
Oncogene, 2004 Src family tyrosine kinases (SFKs) are involved in a diverse array of physiological processes, as highlighted in this review. An overview of how SFKs interact with, and participate in signaling from, receptor tyrosine kinases (RTKs) is discussed.
Courtneidge, Sara A. +5 more
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