Results 21 to 30 of about 61,368 (147)
The tyrosine kinase Csk dimerizes through Its SH3 domain. [PDF]
PLoS ONE, 2009 The Src family kinases possess two sites of tyrosine phosphorylation that are critical to the regulation of kinase activity. Autophosphorylation on an activation loop tyrosine residue (Tyr 416 in commonly used chicken c-Src numbering) increases catalytic
Nicholas M Levinson +2 more
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The Role of Src Family Kinases in Neuroendocrine Tumors [PDF]
Gastroenterology, 2012 [No abstract available]
Capurso, G +2 more
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Regulation of Fibroblast Cell Polarity by Src Tyrosine Kinase
Biomedicines, 2021 Src protein tyrosine kinases (SFKs) are a family of nonreceptor tyrosine kinases that are localized beneath the plasma membrane and are activated during cell adhesion, migration, and elongation.
Kazuo Katoh
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Diverse Requirements for Src-Family Tyrosine Kinases Distinguish Chlamydial Species
mBio, 2011 Chlamydiae are well known for their species specificity and tissue tropism, and yet the individual species and strains show remarkable genomic synteny and share an intracellular developmental cycle unique in the microbial world.
Jeffrey Mital, Ted Hackstadt
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Journal of Inflammation, 2006 Background Yeast and bacteria elicit arachidonate release in macrophages, leading to the formation of leukotrienes and prostaglandins, important mediators of inflammation.
Sundler Roger, Olsson Sandra
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Targeting Src family kinases inhibits bevacizumab-induced glioma cell invasion. [PDF]
PLoS ONE, 2013 Anti-VEGF antibody therapy with bevacizumab provides significant clinical benefit in patients with recurrent glioblastoma multiforme (GBM). Unfortunately, progression on bevacizumab therapy is often associated with a diffuse disease recurrence pattern ...
Deborah Huveldt +8 more
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Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk
BMC Immunology, 2001 Background The Tec family kinases are implicated in signaling from lymphocyte antigen receptors and are activated following phosphorylation by Src kinases.
Debnath Jayanta +6 more
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Frontiers in Immunology, 2017 In a synthetic biology approach using Schneider (S2) cells, we show that SLP-76 is directly phosphorylated at tyrosines Y113 and Y128 by SYK in the presence of ITAM-containing adapters such as CD3ζ, DAP12, or FcεRγ.
Frank Fasbender +4 more
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Regulation of Src Family Kinases in Human Cancers [PDF]
Journal of Signal Transduction, 2011 The nonreceptor protein tyrosine kinase Src plays a crucial role in the signal transduction pathways involved in cell division, motility, adhesion, and survival in both normal and cancer cells. Although the Src family kinases (SFKs) are activated in various types of cancers, the exact mechanisms through which they contribute to the progression of ...
Sen, Banibrata, Johnson, Faye M.
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Regulation of Btk by Src Family Tyrosine Kinases [PDF]
Molecular and Cellular Biology, 1996 Loss of function of Bruton's tyrosine kinase (Btk) results in X-linked immunodeficiencies characterized by a broad spectrum of signaling defects, including those dependent on Src family kinase-linked cell surface receptors. A gain-of-function mutant, Btk*, induces the growth of fibroblasts in soft agar and relieves the interleukin-5 dependence of a pre-
D E, Afar +5 more
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