Results 61 to 70 of about 61,368 (147)
A Dimerization Function in the Intrinsically Disordered N-Terminal Region of Src
Cell Reports, 2018 Summary: The mode of regulation of Src kinases has been elucidated by crystallographic studies identifying conserved structured protein modules involved in an orderly set of intramolecular associations and ligand interactions.
Danislav S. Spassov +3 more
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Src family kinases and their role in hematological malignancies
Leukemia & Lymphoma, 2015 The Src family protein tyrosine kinases (SFKs) are non-receptor intracellular kinases that have important roles in both hematopoiesis and leukemogenesis. The derangement of their expression or activation has been demonstrated to contribute to hematological malignancies. This review first examines the mechanisms of SFK overexpression and hyperactivation,
Ku, Matthew +9 more
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Src family kinases in the nervous system [PDF]
The FEBS Journal, 2011 Accompanied by a podcast, listen now.
Xian‐Min Yu, Bradley R. Groveman
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Journal of Pharmacological Sciences, 2011 .: Oxidative stress is considered a major mediator of arteriosclerosis. In vascular smooth muscle cells, oxidative stress–induced cell death (including apoptosis) is probably related to arterial calcification in arteriosclerosis.
Jing Zhao +5 more
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The role of Src family kinases in egg activation
Developmental Biology, 2007 The Src family kinases (SFKs) are believed to mediate some of the early events of egg activation at fertilization--intracellular Ca2+ increase and resumption of the second meiotic division (RMII). SFKs are both necessary and sufficient for triggering intracellular Ca2+ increase in eggs of sea urchin, sea star, Xenopus etc, but their role in mammalian ...
Reut, Tomashov-Matar +4 more
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Blood, 2007 IgE/antigen-dependent mast cell activation plays a central role in immediate hypersensitivity and other allergic reactions. The Src family tyrosine kinase (SFK) Lyn is activated by the cross-linking of high-affinity IgE receptors (FcϵRI). Activated Lyn phosphorylates the FcϵRI subunits, β and γ, leading to subsequent activation of various signaling ...
Hong, Hong +7 more
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Role of
Malaria Journal, 2008 Background Thrombospondin-related anonymous protein (TRAP) is essential for sporozoite motility and for liver cell invasion. TRAP is a type 1 membrane protein that possesses multiple adhesive domains in its extracellular region.
Malhotra Pawan +3 more
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Proceedings, 2019 The Src, a protein kinase, is a family of protein tyrosine kinases (SFKs), and this protein catalyses the phosphorylation of tyrosine. The studies have revealed its key roles in regulating signal transduction from cell surface receptors.
Filiz Bakar-Ates
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BMC Cell Biology, 2004 Background The guanine nucleotide exchange factor C3G (RapGEF1) along with its effector proteins participates in signaling pathways that regulate eukaryotic cell proliferation, adhesion, apoptosis and embryonic development.
Radha Vegesna +2 more
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Intramolecular Fuzzy Interactions Involving Intrinsically Disordered Domains
Frontiers in Molecular Biosciences, 2018 Structural disorder is an essential ingredient for function in many proteins and protein complexes. Fuzzy complexes describe the many instances where disorder is maintained as a critical element of protein interactions.
Miguel Arbesú +4 more
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