Results 131 to 140 of about 512,141 (378)
HIFα as a target for different oncoproteins during carcinogenesis
Успехи молекулярной онкологии, 2019 The basic characteristics of tumours are ability for invasiveness and metastasis. These properties are realized due to destruction of intercellular matrix caused with acidification of intercellular area stimulated with transition from tissue respiration ...
V. A. Kobliakov
doaj +1 more source
Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn. [PDF]
, 2000 Macrophage Fcgamma receptors (FcgammaRs) mediate the uptake and destruction of antibody-coated viruses, bacteria, and parasites. We examined FcgammaR signaling and phagocytic function in bone marrow-derived macrophages from mutant mice lacking the major ...
Crowley, MT +6 more
core
PLoS ONE, 2014 SRC, also known as proto-oncogene c-Src, is a non-receptor tyrosine kinase that plays an important role in cancer progression by promoting survival, angiogenesis, proliferation, and invasion pathways.
Nan Wang +12 more
semanticscholar +1 more source
Advanced Science, EarlyView.CRISPR/Cas9 screening reveals PTPN2 as essential for ALK+ ALCL survival. PTPN2 regulates TFRC to promote PINK1‐PRKN mitophagy. Oral PTPN2 inhibitor ABBV‐CLS‐484 disrupts mitochondrial renewal and blocks TFRC‐mediated mitophagy to exert anti‐tumor activities, supporting clinical development for ALK+ ALCL.
Wei‐Ting Wang +11 more
wiley +1 more source
Autophagic degradation of focal adhesions underlies metastatic cancer dissemination
Molecular & Cellular Oncology, 2017 Autophagy inhibition is being evaluated as a novel therapeutic strategy in multiple tumor types, but little is known about its implications for metastatic dissemination.
Marina N. Sharifi +2 more
doaj +1 more source
Advanced Science, EarlyView.This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu +10 more
wiley +1 more source
The Shuilian Cave in the Upper Region of the Chang River (Karst of NW Yunnan, China)
Acta Carsologica, 2009 In upper reaches of the Chang (Yangtze) river, in Deqen prefecture, in northwestern part of the Yunnan province, karst is developed in Devonian carbonate rocks.
Martin Knez +5 more
doaj +1 more source
Supplier-retailer collaboration in food networks: a typology and examination of moderating factors [PDF]
, 2004 The aim of this study is to examine Supplier-Retailer Collaboration (SRC) in food networks. Based on an extensive literature on the structural characteristics of trade collaborations, we develop a three dimensional construct of SRC which includes trade ...
Karalis, Vassilis, Vlachos, Ilias
core
Advanced Science, EarlyView.The co‐delivery of mRNAs encoding a CD47 inhibitor and a cytokine cocktail (interleukins 12, 15, and 21) via lipid nanoparticles enables effective localized immunotherapy. This strategy not only suppresses tumor progression but also enhances type 1 conventional dendritic cell (cDC1) differentiation and activates CD8+ T cells, thereby inducing robust ...
Tao Jiang +14 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang +9 more
wiley +1 more source