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CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES
Annual Review of Cell and Developmental Biology, 1997▪ Abstract Src family protein tyrosine kinases are activated following engagement of many different classes of cellular receptors and participate in signaling pathways that control a diverse spectrum of receptor-induced biological activities. While several of these kinases have evolved to play distinct roles in specific receptor pathways, there is ...
Joan Brugge +2 more
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Structure and dynamic regulation of Src-family kinases
Cellular and Molecular Life Sciences, 2008Src-family kinases are modular signaling proteins involved in a diverse array of cellular processes. All members of the Src family share the same domain organization, with modular SH3, SH2 and kinase domains followed by a C-terminal negative regulatory tail.
Thomas Smithgall +2 more
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Structures of Src-family tyrosine kinases
Current Opinion in Structural Biology, 1997The crystal structures of three Src-family tyrosine kinases have been determined recently. The structure of the catalytic domain of Lck has been determined in the active autophosphorylated state. The structures of larger constructs of c-Src and Hck, containing the SH3, SH2 and catalytic domains, as well as a C-terminal regulatory tail, have been ...
F, Sicheri, J, Kuriyan
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Encodable Activators of Src Family Kinases
Journal of the American Chemical Society, 2006There is considerable current interest in the design of encodable molecules that regulate intracellular protein circuitry and/or activity, ideally with a high level of specificity. Src homology 3 (SH3) domains are ubiquitous components of multidomain signaling proteins, including many kinases, and are attractive drug targets because of the important ...
Crystal D, Zellefrow +7 more
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Fyn, a Src family tyrosine kinase
The International Journal of Biochemistry & Cell Biology, 1998Fyn is a 59 kDa member of the Src family of tyrosine kinases. The protein is synthesized and N-myristoylated on cytosolic polysomes and then rapidly targeted to the plasma membrane, where it is palmitoylated. Dually acylated Fyn clusters in caveolae-like membrane microdomains, and can interact with a variety of other signaling molecules.
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The role of SRC family kinases in FLT3 signaling
The International Journal of Biochemistry & Cell Biology, 2019The receptor tyrosine kinase FLT3 is expressed almost exclusively in the hematopoietic compartment. Binding of its ligand, FLT3 ligand (FL), induces dimerization and activation of its intrinsic tyrosine kinase activity. This leads to autophosphorylation of FLT3 on several tyrosine residues which constitute high affinity binding sites for signal ...
Julhash U. Kazi, Lars Rönnstrand
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Src family kinases in tumor progression and metastasis
Cancer and Metastasis Reviews, 2003The Src family of non-receptor protein tyrosine kinases plays critical roles in a variety of cellular signal transduction pathways, regulating such diverse processes as cell division, motility, adhesion, angiogenesis, and survival. Constitutively activated variants of Src family kinases, including the viral oncoproteins v-Src and v-Yes, are capable of ...
Justin M, Summy, Gary E, Gallick
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Role of Src Family Kinases in Prolactin Signaling
2014Prolactin (PRL) is a polypeptide hormone/cytokine mainly synthesized by the lactotrophic cells of the adenohypophysis. In addition to the best-known role in mammary gland development and the functional differentiation of its epithelium, PRL is involved in regulation of multiple physiological processes in higher organisms contributing to their ...
Martín-Pérez, Jorge +4 more
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Regulation of src family tyrosine kinases in lymphocytes
Trends in Biochemical Sciences, 1993An immune response is initiated by activation of antigen-specific lymphoid cells via receptors on the cell surface. Recent advances have begun to unravel the molecular pathways by which the signals from these surface receptors are transduced into the cells and affect the cell's behavior.
T, Mustelin, P, Burn
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