Results 91 to 100 of about 64,838 (284)

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, EarlyView.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

Big Mitogen-Activated Protein Kinase 1 Protects Cultured Rat Aortic Smooth Muscle Cells From Oxidative Damage

Journal of Pharmacological Sciences, 2011
.: Oxidative stress is considered a major mediator of arteriosclerosis. In vascular smooth muscle cells, oxidative stress–induced cell death (including apoptosis) is probably related to arterial calcification in arteriosclerosis.
Jing Zhao, Yoji Kyotani, Satoyasu Itoh, Hitoshi Nakayama, Minoru Isosaki, Masanori Yoshizumi   +5 more
doaj   +1 more source

Hybrid and rogue kinases encoded in the genomes of model eukaryotes. [PDF]

PLoS ONE, 2014
The highly modular nature of protein kinases generates diverse functional roles mediated by evolutionary events such as domain recombination, insertion and deletion of domains.
Ramaswamy Rakshambikai, Mutharasu Gnanavel, Narayanaswamy Srinivasan   +2 more
doaj   +1 more source

Fertilization triggers localized activation of Src-family protein kinases in the zebrafish egg

, 2006
Fertilization triggers activation of Src-family kinases in eggs of various species including marine invertebrates and lower vertebrates. While immunofluorescence studies have localized Src-family kinases to the plasma membrane or cortical cytoplasm, no ...
Dipika Sharma, William H. Kinsey, Sharma, Dipika, Kinsey, William H.   +3 more
core   +1 more source

The role of Src family kinases in egg activation

Developmental Biology, 2007
The Src family kinases (SFKs) are believed to mediate some of the early events of egg activation at fertilization--intracellular Ca2+ increase and resumption of the second meiotic division (RMII). SFKs are both necessary and sufficient for triggering intracellular Ca2+ increase in eggs of sea urchin, sea star, Xenopus etc, but their role in mammalian ...
Reut, Tomashov-Matar, Mattan, Levi, Dafna, Tchetchik, Ruth, Kaplan-Kraicer, Ruth, Shalgi   +4 more
openaire   +2 more sources

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

The role of Src family kinases in RNA processing

, 2010
Until now, a lot of information have been obtained about the role of Src family kinases in the cytoplasm or at the plasma membrane and their interactions with growth factor receptors or focal adhesion complexes.
Gemperle, Jakub
core   +1 more source

The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn

Blood, 2007
IgE/antigen-dependent mast cell activation plays a central role in immediate hypersensitivity and other allergic reactions. The Src family tyrosine kinase (SFK) Lyn is activated by the cross-linking of high-affinity IgE receptors (FcϵRI). Activated Lyn phosphorylates the FcϵRI subunits, β and γ, leading to subsequent activation of various signaling ...
Hong, Hong, Jiro, Kitaura, Wenbin, Xiao, Vaclav, Horejsi, Chisei, Ra, Clifford A, Lowell, Yuko, Kawakami, Toshiaki, Kawakami   +7 more
openaire   +3 more sources