Results 51 to 60 of about 40,020 (266)

Daily‐Life, Sensor‐Derived Tremor Measures Are Sensitive to Progression in Early Parkinson's Disease

Annals of Neurology, EarlyView.
Objective Sensitive outcome measures are critical for evaluating the efficacy of novel treatments for Parkinson's disease (PD). In this study, we assess the sensitivity to change of sensor‐derived daily‐life tremor measures over 2 years in unmedicated and medicated persons with early PD.
Nienke A. Timmermans, Ioan Gabriel Bucur, Diogo C. Soriano, Erik Post, Hayriye Cagnan, Sooyoon Shin, Max A. Little, Yordan P. Raykov, Bastiaan R. Bloem, Rick C. Helmich, Luc J.W. Evers   +10 more
wiley   +1 more source

Redescription of the Triassic cynodont Cistecynodon parvus and reassessment of its phylogeny

The Anatomical Record, EarlyView.
Abstract Cynodontia is an important subclade of Therapsida that first occurred in the late Permian. It includes extinct subclades which are the non‐mammaliaform cynodonts and Mammaliaformes, with the latter ultimately giving rise to crown mammals. The systematics of non‐mammaliaform cynodonts has been extensively studied and is relatively well‐resolved,
Erin S. Lund, Frederik P. Wolvaardt, Roger M. H. Smith, Jaganmoy Jodder, Julien Benoit   +4 more
wiley   +1 more source

Failure Rates and Patient‐Reported Outcomes Are Similar Across 5 Arthroscopic, Suprapectoral Biceps Tenodesis Fixation Techniques

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To compare failure rates and patient‐reported outcome measures (PROMs) across 5 arthroscopic, suprapectoral biceps tenodesis fixation techniques: tenodesis screw, tenodesis anchor, expanding tenodesis anchor, onlay with single all‐suture anchor, and soft tissue tenodesis in the bicipital groove with suture.
Senah E. Stephens, Samantha M. Strohm, Rachael M. Shaughnessy, Katherine S. Worcester, Kevin F. Bonner   +4 more
wiley   +1 more source

Actualisering en addenda SRM-1 en SRM-2

, 2020
De Nederlandse overheid stelt rekenmodellen vast om de luchtkwaliteit langs wegen te berekenen. Met behulp van zogeheten technische rekenregels kunnen de rekenmodellen de luchtkwaliteit in een bepaalde omgeving goed berekenen. Het RIVM heeft in 2014 de technische regels voor het rekenen in een stedelijke omgeving (SRM-1) en langs (snel)wegen (SRM-2) in
Visser, S, Wesseling, J
openaire   +2 more sources

Ten Minutes of Passive Hip and Knee Joint Movement Reduces Stiffness Due to Osgood‐Schlatter Disease in the Rectus Femoris Muscle

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To investigate the acute effects of passive movement on rectus femoris (RF) stiffness, flexibility, and subjective knee joint pain in patients with Osgood‐Schlatter disease (OSD). Methods Patients with bilateral OSD at the orthopedic clinic between July 2023 and June 2025 were prospectively enrolled.
Takayuki Inami, Naoki Ikeda, Shota Yamaguchi, Genko Karasawa   +3 more
wiley   +1 more source

Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a multiorgan disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb–Drug Interaction Investigation

Biopharmaceutics &Drug Disposition, EarlyView.
Pharmacokinetic interactions between Echinacea and two antiviral drugs, favipiravir and atazanavir, were assessed in rats. The findings suggest that Echinacea does not significantly affect the pharmacokinetics of favipiravir and atazanavir. These results provide preliminary evidence that concurrent use of Echinacea with these antiviral drugs may be ...
Siva Nageswara Rao Gajula, Jeevan Sai Kallam, Aarika Kanukolanu, Ganesh Korada, Lakshmi Vineela Nalla   +4 more
wiley   +1 more source

β‐1,4‐galactosyltransferase 1 inhibitors modulate cellular N‐glycan profiles

Biotechnology Progress, EarlyView.
Graphical representation of the study workflow used to investigate the effects of known in vitro galactosyltransferase inhibitors on cell culture performance and recombinant IgG galactosylation. Abstract N‐glycosylation is a key post‐translational modification of proteins influencing their physicochemical properties as well as biological activity. This
Jaka Kranjc, Stane Pajk, Marko Anderluh, Anja Pišlar, Matjaž Brinc   +4 more
wiley   +1 more source

Resistance and Resilience of Sulfidogenic Communities in the Face of the Specific Inhibitor Perchlorate

Frontiers in Microbiology, 2019
Hydrogen sulfide is a toxic and corrosive gas, produced by the activity of sulfate-reducing microorganisms (SRM). Owing to the environmental, economic and human-health consequences of sulfide, there is interest in developing specific inhibitors of SRM ...
Magdalena K. Stoeva, Magdalena K. Stoeva, Gilbert Nalula, Nicholas Garcia, Yiwei Cheng, Anna L. Engelbrektson, Anna L. Engelbrektson, Hans K. Carlson, Hans K. Carlson, Hans K. Carlson, John D. Coates, John D. Coates, John D. Coates   +12 more
doaj   +1 more source