Results 21 to 30 of about 40,396 (302)

Orally administered BZL-sRNA-20 oligonucleotide targeting TLR4 effectively ameliorates acute lung injury in mice

Science China Life Sciences, 2023
The global COVID-19 pandemic emerged at the end of December 2019. Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are common lethal outcomes of bacterial lipopolysaccharide (LPS), avian influenza virus, and SARS-CoV-2.
Dandan Zhao, Yuhao Qin, Jiaqi Liu, Kegong Tang, Shuaiyao Lu, Zirui Liu, Yexuan Lin, Cong Zhang, Fengming Huang, Jiahui Chang, Chang Li, Mingyao Tian, YiMing Ma, Xiaoyun Li, Congzhao Zhou, Xiao Li, Xiaozhong Peng, N. Jin, Chengyu Jiang   +18 more
semanticscholar   +1 more source

CsrA selectively modulates sRNA-mRNA regulator outcomes

Frontiers in Molecular Biosciences, 2023
Post-transcriptional regulation, by small RNAs (sRNAs) as well as the global Carbon Storage Regulator A (CsrA) protein, play critical roles in bacterial metabolic control and stress responses.
A. M. Rojano-Nisimura, Trevor R. Simmons, Abigail N. Leistra, Mia K. Mihailovic, Ryan Buchser, Alyssa M. Ekdahl, Isabella Joseph, N. Curtis, Lydia M. Contreras   +8 more
semanticscholar   +1 more source

Arabidopsis apoplastic fluid contains sRNA- and circular RNA–protein complexes that are located outside extracellular vesicles

bioRxiv, 2021
Previously, we have shown that apoplastic wash fluid purified from Arabidopsis leaves contains small RNAs (sRNAs). To investigate whether these sRNAs are encapsulated inside extracellular vesicles (EVs), we treated EVs isolated from Arabidopsis leaves ...
Hana Zand Karimi, P. Baldrich, Brian D. Rutter, Lucía Borniego, Kamil K. Zajt, B. Meyers, R. Innes   +6 more
semanticscholar   +1 more source

Thirty Years of sRNA-Mediated Regulation in Staphylococcus aureus: From Initial Discoveries to In Vivo Biological Implications

International Journal of Molecular Sciences, 2022
Staphylococcus aureus is a widespread livestock and human pathogen that colonizes diverse microenvironments within its host. Its adaptation to the environmental conditions encountered within humans relies on coordinated gene expression.
Guillaume N. Menard, Chloé Silard, Marie Suriray, A. Rouillon, Y. Augagneur   +4 more
semanticscholar   +1 more source

Galleria mellonella Larvae as an Infection Model to Investigate sRNA-Mediated Pathogenesis in Staphylococcus aureus

Frontiers in Cellular and Infection Microbiology, 2021
Small regulatory RNAs (sRNAs) are key players in bacterial regulatory networks. Monitoring their expression inside living colonized or infected organisms is essential for identifying sRNA functions, but few studies have looked at sRNA expression during ...
G. Ménard, A. Rouillon, Gevorg Ghukasyan, M. Emily, B. Felden, P. Donnio   +5 more
semanticscholar   +1 more source

Regulatory sRNAs in Cyanobacteria [PDF]

Frontiers in Microbiology, 2018
As the transcriptional and post-transcriptional regulators of gene expression, small RNAs (sRNAs) play important roles in every domain of life in organisms. It has been discovered gradually that bacteria possess multiple means of gene regulation using RNAs.
Jinlu Hu, Qiang Wang, Qiang Wang
openaire   +3 more sources

The impact of Hfq-mediated sRNA-mRNA interactome on the virulence of enteropathogenic Escherichia coli

Science Advances, 2021
An elaborate network of sRNA-mRNA interactions controls the pathogenicity of enteropathogenic Escherichia coli.
Sivan Pearl Mizrahi, N. Elbaz, Liron Argaman, Y. Altuvia, Naama Katsowich, Yaakov Socol, A. Bar, I. Rosenshine, H. Margalit   +8 more
semanticscholar   +1 more source

Nuage condensates: accelerators or circuit breakers for sRNA silencing pathways?

RNA: A publication of the RNA Society, 2021
Nuage are RNA-rich condensates that assemble around the nuclei of developing germ cells. Many proteins required for the biogenesis and function of silencing small RNAs (sRNAs) enrich in nuage, and it is often assumed that nuage is the cellular site where
J. P. T. Ouyang, G. Seydoux
semanticscholar   +1 more source

Engineering of the Small Noncoding RNA (sRNA) DsrA Together with the sRNA Chaperone Hfq Enhances the Acid Tolerance of Escherichia coli

Applied and Environmental Microbiology, 2021
Many of the traditional studies on bacterial acid tolerance generally focused on improving cell survival under extreme-pH conditions, but cell growth under less harsh acidic conditions is more relevant to industrial applications. Under normal conditions,
Zhanglin Lin, Jiahui Li, Xiaofang Yan, Jingduan Yang, Xiaofan Li, Ping Chen, Xiaofeng Yang   +6 more
semanticscholar   +1 more source

sRNARFTarget: a fast machine-learning-based approach for transcriptome-wide sRNA target prediction

bioRxiv, 2021
Bacterial small regulatory RNAs (sRNAs) are key regulators of gene expression in many processes related to adaptive responses. A multitude of sRNAs have been identified in many bacterial species; however, their function has yet to be elucidated.
Kratika Naskulwar, Lourdes Peña-Castillo   +1 more
semanticscholar   +1 more source