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BMC Biology, 2023 Background A fraction of all genomes is composed of transposable elements (TEs) whose mobility needs to be carefully controlled. In gonads, TE activity is repressed by PIWI-interacting RNAs (piRNAs), a class of small RNAs synthesized by heterochromatic ...
Amna Asif-Laidin +8 more
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The impact of small RNAs [PDF]
EMBO reports, 2006 Our understanding of the RNA‐mediated gene‐regulatory pathway, known as RNA interference (RNAi), has come a long way since its discovery in the early 1990s. At that time, all knowledge of RNA‐mediated silencing was based on one phenomenon: the loss of a non‐lethal phenotype after the introduction of exogenous RNA into the affected organism. Since then,
Obernosterer, G. +3 more
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Nucleic Acids Research, 1996 The small RNA database is a compilation of all the small size RNA sequences available to date, including nuclear, nucleolar, cytoplasmic and mitochondrial small RNAs from eukaryotic organisms and small RNAs from prokaryotic cells as well as viruses. Currently, about 600 small RNA sequences are in our database.
Jian Gu, Yahua Chen, Ram Reddy
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Early Drought-Responsive Genes Are Variable and Relevant to Drought Tolerance
G3: Genes, Genomes, Genetics, 2020 Drought stress is an important crop yield limiting factor worldwide. Plant physiological responses to drought stress are driven by changes in gene expression.
Cheng He +7 more
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The roles of small RNAs: insights from bacterial quorum sensing [PDF]
ExRNA, 2019 Ribonucleic acids (RNAs) mainly played auxiliary roles in regulations of genetic processes while recent explorations into small non-coding RNAs (sRNAs) in bacteria have broadened the scope of RNAs studies in these processes.
Hongchang Fu +2 more
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Current Biology, 2007 PIWI-interacting RNAs (piRNAs), 24–30 nucleotide long RNAs found in the germ cells of animals, are unique among small silencing RNAs in that they require neither an RdRP nor Dicer for their production (Figure 1Figure 1C). Instead, they are thought to derive from single-stranded precursor RNAs tens or hundreds of thousands of nucleotides long.
Matranga, Christian, Zamore, Phillip D.
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Mechanistic insights into non-coding Y RNA processing
RNA Biology, 2022 Y RNAs (84–112 nt) are non-coding RNAs transcribed by RNA polymerase III and are characterized by a distinctive secondary structure. Human Y RNAs interact with the autoimmune proteins SSB and RO60 that together form a ribonucleoprotein (RNP) complex ...
Martina Billmeier +7 more
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Journal of Cell Science, 2003 Small RNAs have burst on the scene as ubiquitous, versatile repressors of gene expression in plants, animals and many fungi. These tiny RNAs (∼21-26 nt), which induce silencing through homologous sequence interactions, come in many guises: short interfering (si) RNAs ([Elbashir et al., 2001][1]),
E Jean, Finnegan, Marjori A, Matzke
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Non-Coding RNA, 2020 vtRNA2-1 is a vault RNA initially classified as microRNA precursor hsa-mir-886 and recently proposed as “nc886”, a new type of non-coding RNA involved in cancer progression acting as an oncogene and tumor suppressor gene in different tissues.
Rafael Sebastián Fort +3 more
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Cells, 2019 Environmentally-induced transgenerational epigenetic inheritance is an emerging field. The understanding of associated epigenetic mechanisms is currently in progress with open questions still remaining.
Karine Casier +3 more
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