Structural insights into the dynamics and function of the C-terminus of the E. coli RNA chaperone Hfq [PDF]
, 2011 The hexameric Escherichia coli RNA chaperone Hfq (Hfq(Ec)) is involved in riboregulation of target mRNAs by small trans-encoded RNAs. Hfq proteins of different bacteria comprise an evolutionarily conserved core, whereas the C-terminus is variable in ...
Blasi, U. +33 more
core +1 more source
Differential enrichment of 22G-RNA-based epimutations in small-RNA pathways.
, 2023 Bubble plot showing enrichment of different small RNA pathways for 22G-RNA-based epimutations of different durations. Y-axis shows specific small-RNA pathway associated proteins. X-axis shows log2(Odds) of enrichment.
Maxime Le Bourgeois (14710449) +3 more
core +1 more source
Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation [PDF]
, 2007 A family of HEAT-repeat containing ribosome synthesis factors was previously identified in Saccharomyces cerevisiae. We report the detailed characterization of two of these factors, Utp10 and Utp20, which were initially identified as components of the ...
Tollervey, David +2 more
core +1 more source
In vivo self-assembly of small RNAs in extracellular vesicles: a commentary on a new therapeutic paradigm [PDF]
ExRNAExtracellular vesicles (EVs) can transport functional RNA, but the clinical development of EV-based RNA therapeutics has been constrained by the technical demands of ex vivo production and cargo loading.
Azhar Anwar, Xin Yin, Xi Chen
doaj +1 more source
Transfer RNA-derived small RNA: an emerging small non-coding RNA with key roles in cancer
Experimental Hematology & Oncology, 2022 Transfer RNAs (tRNAs) promote protein translation by binding to the corresponding amino acids and transporting them to the ribosome, which is essential in protein translation.
Xinliang Gu +5 more
doaj +1 more source
Techniques for RNA in vivo imaging in plants [PDF]
, 2015 Since the discovery of small RNAs and RNA silencing, RNA biology has taken a centre stage in cell and developmental biology. Small RNAs, but also mRNAs and other types of cellular and viral RNAs are processed at specific subcellular localizations.
Tilsner, Jens, Tilsner, Jens; id_orcid
core +1 more source
One Small RNA of Fusarium graminearum Targets and Silences CEBiP Gene in Common Wheat
Microorganisms, 2019 The pathogenic fungus Fusarium graminearum (F. graminearum), causing Fusarium head blight (FHB) or scab, is one of the most important cereal killers worldwide, exerting great economic and agronomic losses on global grain production.
Jiao Jian, Xu Liang
doaj +1 more source
The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C. elegans [preprint] [PDF]
, 2020 Eukaryotic cells regulate 5' triphosphorylated (ppp-) RNAs to promote cellular functions and prevent recognition by antiviral RNA sensors. For example, RNA capping enzymes possess triphosphatase domains that remove the γ phosphates of ppp-RNAs during RNA
Li, Lichao +8 more
core +1 more source
The RNA Polymerase II-associated factor 1 complex represses small-RNA-mediated heterochromatin formation and gene silencing [PDF]
, 2015 RNAi interference (RNAi) is a highly conserved regulatory mechanism employed by almost all Eukaryotes. With RNAi organisms can modulate the expression of endogenous genes and protect the integrity and identity of their genomes.
Kowalik, Katarzyna Maria
core +1 more source
Bioinformatics approach to processing data from high-throughput sequencing of small RNA molecules
Кардиоваскулярная терапия и профилактикаHigh-throughput sequencing of small ribonucleic acid (RNA) molecules is widely used to search for markers of various diseases, as well as to study the regulation of gene expression.
A. A. Zharikova +3 more
doaj +1 more source