Results 31 to 40 of about 1,523,383 (315)
tRNA Fragments Populations Analysis in Mutants Affecting tRNAs Processing and tRNA Methylation
Frontiers in Genetics, 2020 tRNA fragments (tRFs) are a class of small non-coding RNAs (sncRNAs) derived from tRNAs. tRFs are highly abundant in many cell types including stem cells and cancer cells, and are found in all domains of life.
Anahi Molla-Herman +5 more
doaj +1 more source
RNA Interference and Small RNA Analysis [PDF]
Cold Spring Harbor Protocols, 2019 Small silencing RNAs have provided powerful reverse genetics tools and have opened new areas of research. This introduction describes the use of RNAi to suppress expression of individual genes for loss-of-function analysis. It also summarizes methods for measuring specific and global changes in small RNA expression, as well as methods to inhibit the ...
Chengjian, Li, Phillip D, Zamore
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Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation [PDF]
, 2007 A family of HEAT-repeat containing ribosome synthesis factors was previously identified in Saccharomyces cerevisiae. We report the detailed characterization of two of these factors, Utp10 and Utp20, which were initially identified as components of the ...
Tollervey, David +2 more
core +1 more source
PLoS Genetics, 2008 For several decades, only a limited number of noncoding RNAs, such as ribosomal and transfer RNA, have been studied in any depth. In recent years, additional species of noncoding RNAs have increasingly been discovered. Of these, small RNA species attract particular interest because of their essential roles in processes such as RNA silencing and ...
Hideya Kawaji, Yoshihide Hayashizaki
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Small RNAs making a small protein [PDF]
Proceedings of the National Academy of Sciences, 2007 Small RNAs (sRNAs), often called noncoding RNAs, are widespread in all organisms and are used to control diverse cellular processes. A large class of sRNAs is involved in the regulation of gene expression primarily at posttranscriptional levels through base-pairing.
Teppei, Morita, Hiroji, Aiba
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The RNA Polymerase II-associated factor 1 complex represses small-RNA-mediated heterochromatin formation and gene silencing [PDF]
, 2015 RNAi interference (RNAi) is a highly conserved regulatory mechanism employed by almost all Eukaryotes. With RNAi organisms can modulate the expression of endogenous genes and protect the integrity and identity of their genomes.
Kowalik, Katarzyna Maria
core +1 more source
MSC-derived exosomes for small RNA delivery in disease treatment: a narrative review [PDF]
ExRNAMesenchymal stem cells (MSCs) are known for their ability to differentiate and self-renew, playing a critical role in tissue homeostasis and repair. Despite their therapeutic potential, clinical applications of MSCs face challenges, including safety ...
Ruoyan Zhang, Xu Guo
doaj +1 more source
Cold Spring Harbor Perspectives in Biology, 2013 In plants, RNA silencing is a fundamental regulator of gene expression, heterochromatin formation, suppression of transposable elements, and defense against viruses. The sequence specificity of these processes relies on small noncoding RNA (sRNA) molecules.
Dunoyer, P. +3 more
openaire +3 more sources
Challenges of small RNA technology
, 2020 Plant small RNAs are largely non-coding, regulatory RNAs that act with a sequence-specific binding capacity to regulate target gene expression, either before transcription, a process called transcriptional gene silencing (TGS), or after transcription, a ...
Sveriges lantbruksuniversitet. +1 more
core +1 more source
Transfer RNA-derived small RNA: an emerging small non-coding RNA with key roles in cancer
Experimental Hematology & Oncology, 2022 Transfer RNAs (tRNAs) promote protein translation by binding to the corresponding amino acids and transporting them to the ribosome, which is essential in protein translation.
Xinliang Gu +5 more
doaj +1 more source