Results 51 to 60 of about 1,523,383 (315)

The multifaceted small RNAs [PDF]

RNA Biology, 2008
Small RNA molecules are now being recognized as master regulators of gene activity. Although known initially for their gene-silencing functions, recent discoveries have revealed that small RNAs can also activate gene expression. These two opposing activities of gene silencing and activation together constitute an integrated gene regulatory mechanism.
openaire   +2 more sources

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Diverging affinity of tospovirus RNA silencing suppressor proteins, NSs, for various RNA duplex molecules

, 2010
The tospovirus NSs protein was previously shown to suppress the antiviral RNA silencing mechanism in plants. Here the biochemical analysis of NSs proteins from different tospoviruses, using purified NSs or NSs containing cell extracts, is described.
Kormelink, R.J.M., Rik Huismann, Esther Schnettler, Rob Goldbach, Goldbach, R., Marcel Prins, Goldbach, R.W., Kormelink, R., Hemmes, H., Prins, M., Huismann, R., Hans Hemmes, Huisman, R., Hemmes, J.C., Schnettler, E., Richard Kormelink, Prins, M.W.   +16 more
core   +1 more source

Biotic stress-tolerant plants through small RNA technology

, 2020
With an increasing population around the world, the rapid loss of agricultural fields shows us the urgent importance of finding solutions to develop agricultural productivity.
ATAK, ÇİMEN, MERİÇ, SİNAN, Sinan Meriç, ÇELİK, ÖZGE, Özge Çelik, Çimen Atak, Alp Ayan, AYAN, ALP   +7 more
core   +1 more source

Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires

Cell Reports, 2019
Summary: MicroRNA (miRNA) processing begins with Drosha cleavage, the fidelity of which is critical for downstream processing and mature miRNA target specificity.
Xavier Bofill-De Ros, Wojciech K. Kasprzak, Yuba Bhandari, Lixin Fan, Quinn Cavanaugh, Minjie Jiang, Lisheng Dai, Acong Yang, Tie-Juan Shao, Bruce A. Shapiro, Yun-Xing Wang, Shuo Gu   +11 more
doaj   +1 more source

Identification of oligo-adenylated small RNAs in the parasite Entamoeba and a potential role for small RNA control

BMC Genomics, 2020
Background The RNA interference (RNAi) pathway is a gene regulation mechanism that utilizes small RNA (sRNA) and Argonaute (Ago) proteins to silence target genes.
Hanbang Zhang, Gretchen M. Ehrenkaufer, Neil Hall, Upinder Singh   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Structural insights into the dynamics and function of the C-terminus of the E. coli RNA chaperone Hfq

, 2011
The hexameric Escherichia coli RNA chaperone Hfq (Hfq(Ec)) is involved in riboregulation of target mRNAs by small trans-encoded RNAs. Hfq proteins of different bacteria comprise an evolutionarily conserved core, whereas the C-terminus is variable in ...
Beich-Frandsen, Mads (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Kontaxis, Georg (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Blasi, U., Rajkowitsch, L., Miles, Andrew (Birkbeck College), Sjöblom, Björn (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Miles, Andrew J., Svergun, D.I., Kloiber, K., Kristina Djinović-Carugo, Vecerek, B., Karin Kloiber, Konarev, P.V., Lukas Rajkowitsch, Hämmerle, Hermann Konrad (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Georg Kontaxis, Bläsi, Udo (Department of Microbiology, Immunobiology and Genetics, Centre for Molecular Biology, University of Vienna), Djinovic-Carugo, K., Robert Konrat, Branislav Večerek, Konarev, Peter V. (EMBL Hamburg), Andrew J. Miles, Kloiber, Karin (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Rajkowitsch, Lukas (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Udo Bläsi, Wallace, Bonnie A., Svergun, D. I., Petr V. Konarev, Svergun, Dimitri I. (EMBL Hamburg), Björn Sjöblom, Hammerle, H., Mads Beich-Frandsen, Wallace, B. A., Sjoblom, B., Miles, A. J., Konrat, Robert (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Vecerek, Branislav (Department of Microbiology, Immunobiology and Genetics, Centre for Molecular Biology, University of Vienna), Dimitri I. Svergun, B. A. Wallace, Beich Frandsen, M., Djinovic Carugo, K., Konarev, P. V., Beich-Frandsen, M., Konrat, R., Djinovic-Carugo, Kristina (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Hermann Hämmerle, Kontaxis, G.   +46 more
core   +1 more source

Role of RNA Interference (RNAi) in the Moss Physcomitrella patens [PDF]

, 2013
RNA interference (RNAi) is a mechanism that regulates genes by either transcriptional (TGS) or posttranscriptional gene silencing (PTGS), required for genome maintenance and proper development of an organism.
Arif, M., Basel Khraiwesh, Khraiwesh, Basel, Muhammad Arif, Khraiwesh, B., Arif, Muhammad Asif, Frank, W., Frank, Wolfgang, Wolfgang Frank   +8 more
core   +1 more source

Multifunctional Non-Coding RNAs Mediate Latent Infection and Recurrence of Herpes Simplex Viruses

Infection and Drug Resistance, 2021
Ying Zhang,1– 3,* Li-Si Zeng,4,* Juan Wang,5,* Wen-Qi Cai,2,3 Weiwen Cui,6 Tong-Jun Song,7 Xiao-Chun Peng,2,8 Zhaowu Ma,2,3 Ying Xiang,2,3 Shu-Zhong Cui,4 Hong-Wu Xin2,3 1Department of Gastroenterology, Chun’an County First People’s Hospital (
Zhang Y, Zeng LS, Wang J, Cai WQ, Cui W, Song TJ, Peng XC, Ma Z, Xiang Y, Cui SZ, Xin HW   +10 more
doaj