Results 31 to 40 of about 14,887 (192)
Novel small RNA spike-in oligonucleotides enable absolute normalization of small RNA-Seq data
Scientific Reports, 2017 Normalization of high-throughput small RNA sequencing (sRNA-Seq) data is required to compare sRNA levels across different samples. Commonly used relative normalization approaches can cause erroneous conclusions due to fluctuating small RNA populations ...
Stefan Lutzmayer +2 more
doaj +1 more source
Interkingdom Interactions in the Gut: Ecological Mechanisms, Homeostasis, and Therapeutic Modulation
Gut Medicine, EarlyView.ABSTRACT The gut microbiota constitutes a highly complex and dynamic ecosystem that profoundly influences host physiology, metabolism, and immunity. This review provides an integrative overview of the mechanisms through which gut microorganisms—particularly bacteria and fungi—interact with host cells and with each other to maintain intestinal ...
Rui‐Qi Wei +5 more
wiley +1 more source
Microbial metabolites in tumor epigenetic regulation
iMeta, EarlyView.The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang +31 more
wiley +1 more source
Scientific Reports, 2021 Clostridium tetani produces the tetanus toxin (TeNT), one of the most powerful bacterial toxins known to humankind and responsible for tetanus. The regulation of toxin expression is complex and involves the alternative sigma factor TetR as well as other ...
Holger Brüggemann +3 more
doaj +1 more source
Bacterial sRNAs: Regulation in stress
International Journal of Medical Microbiology, 2013 Bacteria are often exposed to a hostile environment and have developed a plethora of cellular processes in order to survive. A burgeoning list of small non-coding RNAs (sRNAs) has been identified and reported to orchestrate crucial stress responses in bacteria.
Chee-Hock Hoe +3 more
openaire +2 more sources
The Emerging Role of Microbial Extracellular Vesicles in Neuroinflammation and Neurodegeneration
Medicine Bulletin, EarlyView.ABSTRACT Neurodegenerative and neuropsychiatric disorders are increasingly viewed as systemic conditions shaped by interactions among peripheral immunity, microbiota, and the central nervous system. However, the mechanisms linking microbial activity to neuroinflammation and neurodegeneration remain poorly defined.
Julio Jesús Estrada‐Valbuena +3 more
wiley +1 more source
Multiple Small RNAs Interact to Co-regulate Ethanol Tolerance in Zymomonas mobilis
Frontiers in Bioengineering and Biotechnology, 2020 sRNAs represent a powerful class of regulators that influences multiple mRNA targets in response to environmental changes. However, very few direct sRNA–sRNA interactions have been deeply studied in any organism.
Runhua Han +10 more
doaj +1 more source
Elimination of corporal punishment of children's a human right [PDF]
Temida, 2010 The authors indicate the necessity of explicit legal prohibition of all corporal punishment of children that represent a violation of the right of the child to respect his/her physical integrity and human dignity. The paper emphasizes why all corporal
Stevanović Ivana, Srna Jelena
doaj +1 more source
RNase E Finds Some sRNAs Stimulating [PDF]
Molecular Cell, 2012 In this issue of Molecular Cell, Bandyra et al. (2012) describe how a bacterial sRNA can lead to degradation of an mRNA by pairing within the coding region of the mRNA; the 5' monophosphate end of the sRNA activates RNase E, leading to rapid cleavage of the paired mRNA.
De Lay, Nicholas, Gottesman, Susan
openaire +2 more sources
PROTEOMICS, EarlyView.ABSTRACT Honey bees (Apis mellifera) are vital pollinators in fruit‐producing agroecosystems like highbush blueberry (HBB) and cranberry (CRA). However, their health is threatened by multiple interacting stressors, including pesticides, pathogens, and nutritional changes.
Huan Zhong +25 more
wiley +1 more source