Results 1 to 10 of about 1,534 (137)

Tumor-promoting effect and tumor immunity of SRSFs [PDF]

Frontiers in Cell and Developmental Biology
Serine/arginine-rich splicing factors (SRSFs) are a family of 12 RNA-binding proteins crucial for the precursor messenger RNA (pre-mRNA) splicing. SRSFs are involved in RNA metabolism events such as transcription, translation, and nonsense decay during ...
Shuai Zhang, Shuai Zhang, Shuai Zhang, Yongxi Zhang, Sijia Feng, Miaomiao Han, Zixi Wang, Dan Qiao, Jiaqi Tian, Lan Wang, Baoshun Du, Zheying Zhang, Jiateng Zhong, Jiateng Zhong, Jiateng Zhong, Jiateng Zhong   +15 more
doaj   +4 more sources

Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure‐Based Virtual Screening [PDF]

Advanced Science
Pancreatic cancer is an aggressive malignancy with a poor prognosis and limited treatment options. Cdc‐like kinase 4 (CLK4), a kinase that regulates alternative splicing by phosphorylating spliceosome components, is implicated in aberrant splicing events
Chun‐Lin Yang, Yi‐Wen Wu, Huang‐Ju Tu, Yun‐Hsuan Yeh, Tony Eight Lin, Tzu‐Ying Sung, Mu‐Chun Li, Shih‐Chung Yen, Jui‐Hua Hsieh, Ming‐Chin Yu, Sen‐Yung Hsieh, Hsing‐Pang Hsieh, Shiow‐Lin Pan, Kai‐Cheng Hsu   +13 more
doaj   +3 more sources

SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity [PDF]

EMBO Molecular Medicine, 2021
Transcribed CGG repeat expansions cause neurodegeneration in Fragile X‐associated tremor/ataxia syndrome (FXTAS). CGG repeat RNAs sequester RNA‐binding proteins (RBPs) into nuclear foci and undergo repeat‐associated non‐AUG (RAN) translation into toxic ...
Indranil Malik, Yi‐Ju Tseng, Shannon E Wright, Kristina Zheng, Prithika Ramaiyer, Katelyn M Green, Peter K Todd   +6 more
doaj   +3 more sources

Towards understandings of serine/arginine-rich splicing factors [PDF]

Acta Pharmaceutica Sinica B, 2023
Serine/arginine-rich splicing factors (SRSFs) refer to twelve RNA-binding proteins which regulate splice site recognition and spliceosome assembly during precursor messenger RNA splicing.
Dianyang Li, Wenying Yu, Maode Lai
doaj   +2 more sources

Exploring serine-arginine rich splicing factors: potential predictive markers for dysregulation in oral cancer [PDF]

BMC Cancer
Background Dysregulated splicing events are a common phenomenon in cancer with the Serine-arginine-rich splicing factor (SRSF) family emerging as pivotal regulators of gene expression, exerting influence over constitutive and alternative splicing ...
Sakshi Sharma, Manasi Mittal, Akanksha Shukla, Jiyauddin Khan, Veronique Dinand, Daman Saluja   +5 more
doaj   +2 more sources

Multidimensional regulatory roles and therapeutic applications of SRSF7 in cancer [PDF]

Cell Death Discovery
Malignant tumors, as one of the leading causes of mortality, pose great threats to global public health. Serine/Arginine-rich Splicing Factor 7 (SRSF7), a core splicing regulatory protein of the SRSF family, plays a crucial role in maintaining RNA ...
Yuan Li, Huimeng Gao, Xuanyu Zhang, Fuli Sun, Yan Guo, Xue Qiao   +5 more
doaj   +2 more sources

Cross-Effects in Folding and Phase Transitions of hnRNP A1 and C9Orf72 RNA G4 In Vitro [PDF]

Molecules
Abnormal intracellular phase transitions in mutant hnRNP A1 may underlie the development of several neurodegenerative diseases. The risk of these diseases increases upon C9Orf72 repeat expansion and the accumulation of the corresponding G-quadruplex (G4)-
Tatiana Vedekhina, Julia Svetlova, Iuliia Pavlova, Nikolay Barinov, Sabina Alieva, Elizaveta Malakhova, Pavel Rubtsov, Alina Shtork, Dmitry Klinov, Anna Varizhuk   +9 more
doaj   +2 more sources

SRSF3 undergoes phase separation in lung cancer and is associated with immunity and ferroptosis [PDF]

Scientific Reports
As one of the most deadly malignant tumours, lung cancer has been increasing in incidence and mortality worldwide. The incidence and mortality rates of lung cancer are increasing annually.
Lujuan Wang, Yan Lei, Jiao Jiao, Wenjie Pan, Qiu Peng   +4 more
doaj   +2 more sources

Interferon-Regulated Expression of Cellular Splicing Factors Modulates Multiple Levels of HIV-1 Gene Expression and Replication [PDF]

Viruses
Type I interferons (IFN-Is) are pivotal in innate immunity against human immunodeficiency virus I (HIV-1) by eliciting the expression of IFN-stimulated genes (ISGs), which encompass potent host restriction factors.
Fabian Roesmann, Lisa Müller, Katleen Klaassen, Stefanie Heß, Marek Widera   +4 more
doaj   +2 more sources

Combinatorial expression motifs in signaling pathways [PDF]

Cell Genomics
Summary: In animal cells, molecular pathways often comprise families of variant components, such as ligands or receptors. These pathway components are differentially expressed by different cell types, potentially tailoring pathway function to cell ...
Alejandro A. Granados, Nivedita Kanrar, Michael B. Elowitz   +2 more
doaj   +2 more sources