Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling [PDF]
Developmental Cell, 2020 Conserved protein kinases with core cellular functions have been frequently redeployed during metazoan evolution to regulate specialized developmental processes. The Ser/Arg (SR)-rich splicing factor (SRSF) protein kinase (SRPK), which is implicated in splicing regulation, is one such conserved eukaryotic kinase.
Bustos, Francisco +15 more
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SRSFs mediate the function of AR in the ovarian granulosa cells of patients with PCOS
Genes & Diseases, 2021 Ovarian hyperandrogenism is one of the characteristics of polycystic ovary syndrome (PCOS) and androgen receptor (AR) in ovarian granulosa cells (GCs) functions as an important element to the accumulation of androgens. This study verified the existence of alternative splicing variant of AR (AR-SVs) in the GCs of PCOS patients and found that the ...
Jing Luo +6 more
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SRSF‐1 and microvessel density immunohistochemical analysis by semi‐automated tissue microarray in prostate cancer patients with diabetes (DIAMOND study) [PDF]
The Prostate, 2021 AbstractObjectiveTo study the association between insulin receptors (isoforms α and β), insulin growth factor‐1 (IGF1) and serine/arginine splicing factor 1 (SRSF‐1) in patients with prostate cancer (PC) and diabetes.Materials and MethodsWe retrospectively analyzed data from 368 patients who underwent surgery for PC or benign prostatic hyperplasia (BPH)
Broggi G. +8 more
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SRSF shape analysis for sequencing data reveal new differentiating patterns [PDF]
Computational Biology and Chemistry, 2017 AbstractMotivationSequencing-based methods to examine fundamental features of the genome, such as gene expression and chromatin structure, rely on inferences from the abundance and distribution of reads derived from Illumina sequencing. Drawing sound inferences from such experiments relies on appropriate mathematical methods to model the distribution ...
Wesolowski, Sergiusz +2 more
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Comprehensive Molecular Analysis Identified an SRSF Family-Based Score for Prognosis and Therapy Efficiency Prediction in Hepatocellular Carcinoma [PDF]
Cancers, 2022 The serine/arginine-rich splicing factors (SRSF)-mediated alternative splicing plays an essential role in the occurrence and progression of hepatocellular carcinoma (HCC). However, the SRSF-based signature that can predict the prognosis and therapy efficiency is yet to be investigated in HCC.
Jingsheng Yuan +4 more
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Single neuron transcriptomics identify SRSF/SR protein B52 as a regulator of axon growth and Choline acetyltransferase splicing [PDF]
Scientific Reports, 2016 AbstractWe removed single identified neurons from living Drosophila embryos to gain insight into the transcriptional control of developing neuronal networks. The microarray analysis of the transcriptome of two sibling neurons revealed seven differentially expressed transcripts between both neurons (threshold: log21.4).
Boyin Liu, Torsten Bossing
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Systematic Analysis Of Expression Profiles Of SRSF Family Members For Prognostic Application In DLBCL [PDF]
, 2023 Abstract Diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype of non-Hodgkin’s lymphoma. Serine and arginine-rich splicing factors (SRSF) family is an important splicing regulator and plays vital roles in RNA nuclear transportation and RNA stability. However, the role of the SRSF family in DLBCL is still unknown.
Zanzan Wang +4 more
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Efficient progerin clearance through autophagy induction and SRSF-1 downregulation in Hutchinson-Gilford Progeria Syndrome [PDF]
Orphanet Journal of Rare Diseases, 2015 Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare premature and accelerated aging disease caused by a de novo point mutation in LMNA encoding A-type lamins. Progerin, a truncated and toxic form of prelamin A, accumulates in HGPS cells nuclei and is a hallmark of the disease.
Karim Harhouri
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Access Microbiology, 2019 Introduction HRV infections cause asthma exacerbations, while HRV-induced wheezing in pre-school children is associated with asthma development in later life. Molecular mechanisms underlying this pathophysiology remain elusive, while HRV-C is increasingly associated with disease severity.
Christoforos Rozario +3 more
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Secured Requirement Specification Framework (SRSF) [PDF]
American Journal of Applied Sciences, 2008 Generally, software engineers are poorly trained to elicit, analyze and specify security requirements, often confusing them with the architectural security mechanisms that are traditionally used to fulfill them. One of the most ignored parts of a security-enhanced software development lifecycle is the security requirements engineering process. Security
R.A. Khan, K. Mustafa
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