Results 21 to 30 of about 1,582 (144)

Cardiac glycosides correct aberrant splicing of IKBKAP‐encoded mRNA in familial dysautonomia derived cells by suppressing expression of SRSF3 [PDF]

The FEBS Journal, 2013
The ability to modulate the production of the wild‐type transcript in cells bearing the splice‐altering familial dysautonomia (FD) causing mutation in the IKBKAP gene prompted a study of the impact of a panel of pharmaceuticals on the splicing of this transcript, which revealed the ability of the cardiac glycoside digoxin to increase the production of ...
Bo, Liu, Sylvia L, Anderson, Jinsong, Qiu, Berish Y, Rubin   +3 more
openaire   +4 more sources

CDK12‐inactivation‐induced MYC signaling causes dependency on the splicing kinase SRPK1 [PDF]

Molecular Oncology
Inactivation of cyclin‐dependent kinase 12 (CDK12) characterizes an aggressive sub‐group of castration‐resistant prostate cancer (CRPC). Hyper‐activation of MYC transcription factor is sufficient to confer the CRPC phenotype.
Jing Liang, Aishwarya Gondane, Harri M. Itkonen   +2 more
doaj   +2 more sources

Targeting the CLK 2/ SRSF 9 splicing axis in prostate cancer leads to decreased ARV 7 expression

Molecular Oncology
In advanced prostate cancer (PC), in particular after acquisition of resistance to androgen receptor (AR) signaling inhibitors (ARSI), upregulation of AR splice variants compromises endocrine therapy efficiency. Androgen receptor splice variant‐7 (ARV7) is clinically the most relevant and has a distinct 3′ untranslated region (3 ...
Jasper Van Goubergen, Miroslav Peřina, Florian Handle, Elisa Morales, Anika Kremer, Oliver Schmidt, Glen Kristiansen, Marcus V. Cronauer, Frédéric R. Santer   +8 more
openaire   +4 more sources

SRSF protein kinase 2 (SRPK2) [PDF]

Science-Business eXchange, 2012
openaire   +2 more sources

SRSF Protein Kinase 1 [PDF]

, 2020
National Cancer Institute
openaire   +2 more sources

Screening for ASXL1 and SRSF2 mutations is imperative for treatment decision‐making in otherwise low or intermediate‐1 risk patients with myelofibrosis [PDF]

British Journal of Haematology, 2017
Ayalew Tefferi, Terra L. Lasho, Curtis A. Hanson, Rhett P. Ketterling, Naseema Gangat, Animesh Pardanani   +5 more
openaire   +3 more sources

Abstract 2417 Serine starvation inhibits SRSF protein expression and modulates RNA splicing

Journal of Biological Chemistry
Philippa Burns, Negar Tabatabaei, Laura Selfors, Aanshi Vashi, Debolanle Dahunsi, Patrick Murphy, Soroush Tahmasebi, Jonathan Coloff   +7 more
openaire   +3 more sources

Improved Forward Osmosis Performance of Thin Film Composite Membranes with Graphene Quantum Dots Derived from Eucalyptus Tree Leaves

Nanomaterials, 2022
The major challenges in forward osmosis (FO) are low water flux, high specific reverse solute flux (SRSF), and membrane fouling. The present work addresses these problems by the incorporation of graphene quantum dots (GQDs) in the polyamide (PA) layer of
Haleema Saleem, Asif Saud, Nazmin Munira, Pei Sean Goh, Ahmad Fauzi Ismail, Hammadur Rahman Siddiqui, Syed Javaid Zaidi   +6 more
doaj   +1 more source

An IGF-1R-mTORC1-SRPK2 signaling Axis contributes to FASN regulation in breast cancer

BMC Cancer, 2022
Background Fatty acid synthase (FASN) expression is associated with a more aggressive breast cancer phenotype and is regulated downstream of receptor tyrosine kinase (RTK) signaling pathways.
Bryan McClellan, Paul Gries, Brittany Harlow, Stefano Tiziani, Christopher Jolly, Linda deGraffenried   +5 more
doaj   +1 more source

SRSF3 Expression Serves as a Potential Biomarker for Prognostic and Immune Response in Pan-Cancer

Frontiers in Oncology, 2022
Serine-rich splicing factor3 (SRSF3) plays an essential role in cell proliferation and inducing and maintaining of cancers as a proto-oncogene. However, the mechanisms of SRSF3 in pan-cancers are still unknown.
Zihua Li, Zihua Li, Hui Huang, Xinbo Wu, Xinbo Wu, Tao Yu, Fajiao Xiao, Haichao Zhou, Anquan Shang, Yunfeng Yang   +9 more
doaj   +1 more source