Results 31 to 40 of about 1,582 (144)

Prior Attention Enhanced Convolutional Neural Network Based Automatic Segmentation of Organs at Risk for Head and Neck Cancer Radiotherapy

IEEE Access, 2020
Aimed to automate the segmentation of organs at risk (OARs) in head and neck (H&N) cancer radiotherapy, we develop a novel Prior Attention enhanced convolutional neural Network (PANet) based Stepwise Refinement Segmentation Framework (SRSF) on full ...
Haibin Chen, Dongyun Huang, Li Lin, Zhenyu Qi, Peiliang Xie, Jun Wei, Lin Chang, Ying Sun, Dongmei Wu, Yao Lu   +9 more
doaj   +1 more source

Long non-coding RNA AFAP1-AS1 promotes alternative splicing of AXIN2 by facilitating SRSFs phase separation to induce drug resistance in lung adenocarcinoma

Molecular Cancer
Jiawei Ouyang, Yijie Zhang, Xiangchan Hou, Fang Xiong, Lei Shi, Yu Zhong, Liting Yang, Can Guo, Zhaoyang Zeng, Qijia Yan, Pan Chen, Wei Xiong   +11 more
openaire   +2 more sources

Splicing factor SRSF1 is essential for CD8 T cell function and host antigen-specific viral immunity

Frontiers in Immunology, 2022
Cytotoxic CD8 T cells are crucial for the host antigen-specific immune response to viral pathogens. Here we report the identification of an essential role for the serine/arginine-rich splicing factor (SRSF) 1 in CD8 T cell homeostasis and function ...
Ignacio Juarez, Ignacio Juarez, Shi Su, Shi Su, Zachary T. Herbert, John R. Teijaro, Vaishali R. Moulton   +6 more
doaj   +1 more source

CAG repeat expansion in the Huntington's disease gene shapes linear and circular RNAs biogenesis.

PLoS Genetics, 2023
Alternative splicing (AS) appears to be altered in Huntington's disease (HD), but its significance for early, pre-symptomatic disease stages has not been inspected.
Dilara Ayyildiz, Guendalina Bergonzoni, Alan Monziani, Takshashila Tripathi, Jessica Döring, Emanuela Kerschbamer, Francesca Di Leva, Elia Pennati, Luisa Donini, Marina Kovalenko, Jacopo Zasso, Luciano Conti, Vanessa C Wheeler, Christoph Dieterich, Silvano Piazza, Erik Dassi, Marta Biagioli   +16 more
doaj   +1 more source

Targeted down-regulation of SRSF1 exerts anti-cancer activity in OSCC through impairing lysosomal function and autophagy

iScience, 2023
Summary: Oral squamous cell carcinoma (OSCC) is a common cancer of the head and neck. Despite ongoing efforts, there remains a dearth of targeted drugs capable of effectively inhibiting OSCC growth.
Yi Qu, Ying He, Yijuan Wang, Zhengxue Han, Lizheng Qin   +4 more
doaj   +1 more source

Comprehensive functional profiling of long non-coding RNAs through a novel pan-cancer integration approach and modular analysis of their protein-coding gene association networks

BMC Genomics, 2019
Background Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of cellular processes in diseases such as cancer, although the functions of most remain poorly understood.
Kevin Walters, Radmir Sarsenov, Wen Siong Too, Roseanna K. Hare, Ian C. Paterson, Daniel W. Lambert, Stephen Brown, James R. Bradford   +7 more
doaj   +1 more source

Graphene Oxide Incorporated Forward Osmosis Membranes With Enhanced Desalination Performance and Chlorine Resistance

Frontiers in Chemistry, 2020
In this work, grapheme oxide (GO) nano-sheets were synthesized and dispersed in the aqueous phase for the interfacial polymerization (IP) process to develop a new type of thin-film composite (TFC) membranes for forward osmosis (FO) applications.
Zhanguo Li, Yi Wang, Yi Wang, Mengwei Han, Dayong Wang, Shitong Han, Zequn Liu, Ningyu Zhou, Ran Shang, Chaoxin Xie   +9 more
doaj   +1 more source

Data Acquisition System for On-the-Go Soil Resistance Force Sensor Using Soil Cutting Blades

Sensors, 2022
Worldwide, agricultural land is a dominant part of the environment. It is very important to understand the physical properties of soil because they directly or indirectly affect the entire human population.
Vladimír Cviklovič, Miroslav Mojžiš, Radoslav Majdan, Katarína Kollárová, Zdenko Tkáč, Rudolf Abrahám, Soňa Masarovičová   +6 more
doaj   +1 more source

The potential role of U2AF1L4 cDNA 3’ stretch mutations in oral carcinogenesis

Advances in Cancer Biology - Metastasis, 2022
Background: U2 small nuclear RNA auxiliary factor 1-like protein 4 (U2AF1L4) plays a crucial role in the physiological alternative splicing of pre-mRNA pools.
Sapna Khowal, Saima Wajid
doaj   +1 more source

MG132‐induced progerin clearance is mediated by autophagy activation and splicing regulation

EMBO Molecular Medicine, 2017
Hutchinson–Gilford progeria syndrome (HGPS) is a lethal premature and accelerated aging disease caused by a de novo point mutation in LMNA encoding A‐type lamins.
Karim Harhouri, Claire Navarro, Danielle Depetris, Marie‐Geneviève Mattei, Xavier Nissan, Pierre Cau, Annachiara De Sandre‐Giovannoli, Nicolas Lévy   +7 more
doaj   +1 more source