Results 41 to 50 of about 1,582 (144)

Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway

BMC Genomics, 2012
Background Genome-scale RNA-interference (RNAi) screens are becoming ever more common gene discovery tools. However, whilst every screen identifies interacting genes, less attention has been given to how factors such as library design and post-screening ...
Fisher Katherine H, Wright Victoria M, Taylor Amy, Zeidler Martin P, Brown Stephen   +4 more
doaj   +1 more source

Serine/arginine-rich splicing factors 2 (SRSF2) and SRSF4 expression patterns in Korean with colon cancer [PDF]

Korean Journal of Clinical Oncology, 2016
Purpose Splicing factors play important roles in tumorigenesis. Serine/arginine-rich splicing factors 2 (SRSF2) and SRSF4 proteins, the members of SR family proteins, are dysregulated in various cancers.
Jin-Whi Kim, Do-Sim Park, Won-Cheol Park, Sora Ahn, Dong-Back Kang, Keun-Young Kim, Yong Kim   +6 more
doaj   +1 more source

SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps

Frontiers in Immunology, 2022
Efficient HIV-1 replication depends on balanced levels of host cell components including cellular splicing factors as the family of serine/arginine-rich splicing factors (SRSF, 1–10).
Helene Sertznig, Fabian Roesmann, Alexander Wilhelm, Delia Heininger, Barbara Bleekmann, Carina Elsner, Mario Santiago, Jonas Schuhenn, Zehra Karakoese, Yvonne Benatzy, Ryan Snodgrass, Stefan Esser, Kathrin Sutter, Ulf Dittmer, Marek Widera, Marek Widera   +15 more
doaj   +1 more source

Computational analysis of crosstalk between transcriptional regulators and RNA-binding proteins suggests mutual regulation of polycomb proteins and SRSF1 influencing adult hippocampal neurogenesis

Discover Mental Health, 2023
Background Adult hippocampal neurogenesis (AHN) is a clinically significant neural phenomenon. Understanding its molecular regulation would be important. In this regard, most studies have focused on transcriptional regulators (TRs), epigenetic modifiers,
M. J. Nishanth, Shanker Jha
doaj   +1 more source

SRPK Inhibitors Reduce the Phosphorylation and Translocation of SR Protein Splicing Factors, thereby Correcting BIN1, MCL-1 and BCL2 Splicing Errors and Enabling Apoptosis of Cholangiocarcinoma Cells

Frontiers in Bioscience-Scholar
Background: Cholangiocarcinoma (CCA) is a malignancy of the bile duct epithelium that is commonly found in the Thai population. CCA has poor prognosis and a low survival rate due to the lack of early diagnosis methods and the limited ...
Preenapan Changphasuk, Chaturong Inpad, Sukanya Horpaopan, Sasiprapa Khunchai, Suchada Phimsen, Damratsamon Surangkul, Tavan Janvilisri, Atit Silsirivanit, Worasak Kaewkong   +8 more
doaj   +1 more source

SRSF3 Is a Critical Requirement for Inclusion of Exon 3 of BIS Pre-mRNA

Cells, 2020
BCL-2 interacting cell death suppressor (BIS), also known as BAG3, is a multifunctional protein. Aberrant expression and mutation of BIS have been implicated in cancers and myopathy.
Ji-Ye Baek, Hye-Hyeon Yun, Soon-Young Jung, Jeehan Lee, Kyunghyun Yoo, Jeong-Hwa Lee   +5 more
doaj   +1 more source

Genome-wide landscape of RNA-binding protein (RBP) networks as potential molecular regulators of psychiatric co-morbidities: a computational analysis

Egyptian Journal of Medical Human Genetics, 2023
Background Psychiatric disorders are a major burden on global health. These illnesses manifest as co-morbid conditions, further complicating the treatment.
M. J. Nishanth, Shanker Jha
doaj   +1 more source

Molecular Responses to Climate Change: How Warming and Acidification Reshape the Proteome and Phosphoproteome of the Endangered Mira Chub

Ecology and Evolution, Volume 16, Issue 3, March 2026.
ABSTRACT Global environmental change affects organisms, including their physiology. In freshwater ecosystems, where migration is limited, populations often rely on phenotypic plasticity to respond. While transcriptomics has been widely used to study stress responses at the molecular level, less is known about the proteome, which reflects post ...
João M. Moreno, Jonas Grossmann, Laura Kunz, Antje Dittmann, Vitor C. Sousa, Romana Santos   +5 more
wiley   +1 more source

Glycolysis enzymes and cellular lactylation in tumour

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Graphical Headlights • Glycolytic enzymes regulate lactylation in cancer cells. • Lactylation drives tumour growth, metastasis, immune evasion and contributes to microenvironment remodelling. • Targeting lactylation holds promise for cancer therapy. Abstract Cellular lactylation, a recently identified post‐translational modification, has emerged as a ...
Chenyuan Dai, Lihua Wang
wiley   +1 more source

Interferon‐Driven Biomarkers and Synergistic Therapy for PRMT5 Inhibition in Triple‐Negative Breast Cancer

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Triple‐negative breast cancer exhibits variable sensitivity to PRMT5 inhibition. Basal interferon signaling is identified as a key biomarker of response. PARP inhibition with olaparib induces IFN signaling, sensitizing resistant TNBC cells to PRMT5 inhibitors.
Ziwen Zhang, Sheyu Zhang, Lu Guo, Yichun Pan, Juan Huang, Yishuai Ji, Jiaqi Tao, Yong Wei, Xiaojia Wang, Qin Wu   +9 more
wiley   +1 more source