Results 71 to 80 of about 1,582 (144)

hnRNPC Functions with HuR to Regulate Alternative Splicing in an m6A‐Dependent Manner and is Essential for Meiosis

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This work shows that hnRNPC recognizes and binds directly to key meiosis‐related genes and works with HuR to regulate alternative splicing of its target genes, ensuring the normal production and proper function of essential meiotic transcripts required for meiotic initiation and progression during the first wave of spermatogenesis.
Xinxin Xiong, Shenglei Feng, Xixiang Ma, Kuan Liu, Yiqian Gui, Bei Chen, Xu Fan, Fengli Wang, Xiaoli Wang, Shuiqiao Yuan   +9 more
wiley   +1 more source

MULTI-LABEL RANKING METHOD BASED ON POSITIVE CLASS CORRELATIONS

Jordanian Journal of Computers and Information Technology, 2020
Multi-label classification is a general type of classification that has attracted many researchers in the last two decades due to its applicability to many modern domains, such as scene classification, bioinformatics and text classification, among others.
Raed Alazaidah, Farzana Kabir Ahmad, Mohamad Farhan Mohamad Mohsin, Wael Ahmad AlZoubi   +3 more
doaj   +1 more source

The phosphatase inhibitor LB-100 creates neoantigens in colon cancer cells through perturbation of mRNA splicing

EMBO Reports
Perturbation of protein phosphorylation represents an attractive approach to cancer treatment. Besides kinase inhibitors, protein phosphatase inhibitors have been shown to have anti-cancer activity.
Matheus H Dias, Vladyslava Liudkovska, Jasmine Montenegro Navarro, Lisanne Giebel, Julien Champagne, Chrysa Papagianni, Onno B Bleijerveld, Arno Velds, Reuven Agami, René Bernards, Maciej Cieśla   +10 more
doaj   +1 more source

SRRNet: Unseen SSVEP Response Regression From Stimulus for Cross-Stimulus Transfer in SSVEP-BCIs

IEEE Transactions on Neural Systems and Rehabilitation Engineering
The prolonged calibration time required by steady-state visual evoked potential (SSVEP)-based brain-computer interfaces (BCIs) poses a significant challenge to real-life applications.
Ximing Mai, Jianjun Meng, Yi Ding, Xiangyang Zhu, Cuntai Guan   +4 more
doaj   +1 more source

SRSF1-mediated alternative splicing regulates bladder cancer progression and cisplatin sensitivity through HIF1A/BNIP3/mitophagy axis

Journal of Translational Medicine
Background Alternative splicing (AS) is consistently linked to tumor progression. SRSF1, the first identified proto-oncogene in the serine/arginine-rich splicing factor (SRSF) protein family, plays a crucial role.
Qikai Wu, Hao Yu, Huanyou Sun, Jiancheng Lv, Juntao Zhuang, Lingkai Cai, Lingjing Jiang, Yuhan Chen, Yiran Tao, Kexin Bai, Haiwei Yang, Xiao Yang, Qiang Lu   +12 more
doaj   +1 more source

SRPK1 Promotes Glioma Proliferation, Migration, and Invasion through Activation of Wnt/β-Catenin and JAK-2/STAT-3 Signaling Pathways

Biomedicines
Currently, the treatment of gliomas still relies primarily on surgery and radiochemotherapy. Although there are various drugs available, including temozolomide, the overall therapeutic effect is unsatisfactory, and the prognosis remains poor.
Mengna Shi, Dan Sun, Lu Deng, Jing Liu, Min-Jie Zhang   +4 more
doaj   +1 more source

PROCESSING TOOLS FOR CORPUS LINGUISTICS: A CASE STUDY ON ARABIC HISTORICAL CORPUS

Jordanian Journal of Computers and Information Technology
This paper explores the development, design, and reconstruction of a Historical Arabic Corpus (HAC), which covers more than 1600 years of uninterrupted language use.
Bassam Hasan Hammo, Sane Yagi
doaj   +1 more source

STATE-OF-THE-ART OF MACHINE LEARNING IN NEURO DEVELOPMENT DISORDER: A SYSTEMATIC REVIEW

Jordanian Journal of Computers and Information Technology
This paper presents a comprehensive literature review focusing on the utilization of machine learning (ML) and deep learning (DL) methods for predicting and detecting Neurodevelopmental Disorders (NDDs), such as Intellectual Disability (ID), Autism ...
Lilian Yen Wei Lee, Ag Asri Ag Ibrahim, Rayner Alfred   +2 more
doaj   +1 more source

Targeting SRSF10 might inhibit M2 macrophage polarization and potentiate anti‐PD‐1 therapy in hepatocellular carcinoma

Cancer Communications
Background The efficacy of immune checkpoint blockade therapy in patients with hepatocellular carcinoma (HCC) remains poor. Although serine‐ and arginine‐rich splicing factor (SRSF) family members play crucial roles in tumors, their impact on tumor ...
Jialiang Cai, Lina Song, Feng Zhang, Suiyi Wu, Guiqi Zhu, Peiling Zhang, Shiping Chen, Junxian Du, Biao Wang, Yufan Cai, Yi Yang, Jinglei Wan, Jian Zhou, Jia Fan, Zhi Dai   +14 more
doaj   +1 more source

A New Approach Combining RSA and ElGamal Algorithms: Advancements in Encryption and Digital Signatures Using Gaussian Integers

Jordanian Journal of Computers and Information Technology
This article introduces a novel approach that integrates the ElGamal and RSA algorithms to advance the security and efficiency of public-key cryptosystems.
Yahia Awad, Douaa Jomaa, Yousuf Alkhezi, Ramiz Hindi   +3 more
doaj   +1 more source