Results 91 to 100 of about 5,225 (188)

LncRNA GASAL1 Interacts with SRSF1 to Regulate Trophoblast Cell Proliferation, Invasion, and Apoptosis Via the mTOR Signaling Pathway

Cell Transplantation, 2020
Long noncoding RNAs (lncRNAs) are crucial regulatory molecules involved in diverse biological processes and human diseases, including preeclampsia (PE). The lncRNA growth arrest associated lncRNA 1 (GASAL1) has been implicated in multiple malignant solid
Jia Liu, Qing Zhang, Nan Ma
doaj   +1 more source

Alternative Splicing of SORBS1 Affects Neuromuscular Junction Integrity in Myotonic Dystrophy Type 1

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Myotonic dystrophy type 1 (DM1) is a multisystemic neuromuscular disorder characterized by CTG repeat expansion in the 3′ untranslated region of the dystrophia myotonica protein kinase coding gene. The presence of expanded CTG repeats in DMPK mRNAs leads to the sequestration of RNA‐binding factors such as the Muscleblind‐like (MBNL)
Caroline Hermitte, Hortense de Calbiac, Gilles Moulay, Antoine Mérien, Jeanne Lainé, Hélène Polvèche, Michel Cailleret, Stéphane Vassilopoulos, Edor Kabashi, Denis Furling, Cécile Martinat, Morgan Gazzola   +11 more
wiley   +1 more source

SRSF1 regulates the assembly of pre-mRNA processing factors in nuclear speckles

Molecular Biology of the Cell, 2012
The mammalian cell nucleus is compartmentalized into nonmembranous subnuclear domains that regulate key nuclear functions. Nuclear speckles are subnuclear domains that contain pre-mRNA processing factors and noncoding RNAs. Many of the nuclear speckle constituents work in concert to coordinate multiple steps of gene expression, including transcription,
Tripathi, Vidisha, Song, David Y., Zong, Xinying, Shevtsov, Sergey P., Hearn, Stephen, Fu, Xiang-Dong, Dundr, Miroslav, Prasanth, Kannanganattu V.   +7 more
openaire   +2 more sources

Data from Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation

, 2023
Pushkar Malakar, Asaf Shilo, Adi Mogilevsky, Ilan Stein, Eli Pikarsky, Yuval Nevo, Hadar Benyamini, Sharona Elgavish, Xinying Zong, Kannanganattu V. Prasanth, Rotem Karni   +10 more
openalex   +2 more sources

The GAUGAA Motif Is Responsible for the Binding between circSMARCA5 and SRSF1 and Related Downstream Effects on Glioblastoma Multiforme Cell Migration and Angiogenic Potential [PDF]

, 2021
Davide Barbagallo, A Caponnetto, Cristina Barbagallo, Rosalia Battaglia, Federica Mirabella, Duilia Brex, Michele Stella, Giuseppe Broggi, Roberto Altieri, Francesco Certo, Rosario Caltabiano, Giuseppe Barbagallo, Carmelina Daniela Anfuso, Gabriella Lupo, Marco Ragusa, Cinzia Di Pietro, Thomas B. Hansen, Michele Purrello   +17 more
openalex   +1 more source

circSMARCA5-SRSF1 interaction is functionally involved in GBM pathogenesis

Bullettin of the Gioenia Academy of Natural Sciences of Catania, 2021
Glioblastoma multiforme (GBM) is the most aggressive human brain tumor with a median survival of 15 months. The standard treatments of GBM and the total medical resection are unable to contrast this mortal cancer. For these reason new diagnostic approaches and therapies are needed.
openaire   +2 more sources

lncRNA NUTM2A-AS1 Targets the SRSF1/Trim37 Signaling Pathway to Promote the Proliferation and Invasion of Breast Cancer [PDF]

, 2022
Xiaojie Ning, Jianguo Zhao, Fan He, Yuan Yuan, Bin Li, Jian Ruan   +5 more
openalex   +1 more source

Regulation of Mcl-1 by SRSF1 and SRSF5 in Cancer Cells

PLoS ONE, 2012
Up-regulation of the apoptosis-regulatory gene Mcl-1 (myeloid cell leukemia-1) occurs in different cancer types and is linked with drug resistance to cancer therapies. It is well known that Mcl-1 pre-mRNA undergoes alternative splicing events to produce two functionally distinct proteins, Mcl-1(S) (pro-apoptotic) and Mcl-l(L) (anti-apoptotic); the ...
Gautrey HL, Tyson-Capper AJ
openaire   +5 more sources

The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export

Cell Reports
Summary: Fanconi anemia (FA) is characterized by congenital abnormalities, bone marrow failure, and cancer susceptibility. The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for ...
Anne Olazabal-Herrero, Boxue He, Youngho Kwon, Abhishek K. Gupta, Arijit Dutta, Yuxin Huang, Prajwal Boddu, Zhuobin Liang, Fengshan Liang, Yaqun Teng, Li Lan, Xiaoyong Chen, Huadong Pei, Manoj M. Pillai, Patrick Sung, Gary M. Kupfer   +15 more
doaj   +1 more source

Characteristics of human and viral RNA binding sites and site clusters recognized by SRSF1 and RNPS1

, 2020
Peter K. Rogan, EJ Mucaki, BC Shirley
openalex   +1 more source