Results 181 to 188 of about 5,225 (188)

Effects of SRSF1 on subnuclear localization of topoisomerase I

Journal of Cellular Biochemistry, 2019
AbstractSubnuclear localization of topoisomerase I (top I) is determined by its DNA relaxation activity and a net of its interactions with in majority unidentified nucleolar and nucleoplasmic elements. Here, we recognized SR protein SRSF1 (Serine/arginine‐rich splicing factor 1, previously known as SF2/ASF) as a new element of the net.
Agnieszka Girstun, Takao Ishikawa, Krzysztof Staron   +2 more
openaire   +2 more sources

Activities of Topoisomerase I in Its Complex with SRSF1

Biochemistry, 2012
Human DNA topoisomerase I (topo I) catalyzes DNA relaxation and phosphorylates SRSF1. Whereas the structure of topo I complexed with DNA has been resolved, the structure of topo I in the complex with SRSF1 and structural determinants of topo I activities in this complex are not known.
Takao, Ishikawa, Krystiana A, Krzysko, Barbara, Kowalska-Loth, Aleksandra M, Skrajna, Alicja, Czubaty, Agnieszka, Girstun, Maja K, Cieplak, Bogdan, Lesyng, Krzysztof, Staron   +8 more
openaire   +2 more sources

Transcriptomic reprogramming screen identifies SRSF1 as rejuvenation factor

2023
AbstractAging is a complex process that manifests through the time-dependent functional decline of a biological system. Age-related changes in epigenetic and transcriptomic profiles have been successfully used to measure the aging process1,2. Moreover, modulating gene regulatory networks through interventions such as the induction of the Yamanaka ...
Alexandru M. Plesa, Sascha Jung, Helen H. Wang, Fawad Omar, Michael Shadpour, David Choy Buentello, Maria C. Perez-Matos, Naftali Horwitz, George Cai, Zhen-Kai Ngian, Carol V. de Magalhaes, Amy J. Wagers, William B. Mair, Antonio del Sol, George M. Church   +14 more
openaire   +1 more source

LncRNA MIR181A2HG negatively regulates human keratinocytes proliferation by binding SRSF1

Cytotechnology
Psoriasis is a common chronic inflammatory skin disease. Abnormal proliferation of keratinocytes plays an important role in the pathogenesis of psoriasis. Long non-coding RNAs (lncRNAs) are involved in the regulation of a variety of cell biological processes.
Xiaomei, Fan, Mingzhao, Li, Mutian, Niu, Fangru, Chen, Zhijing, Mo, Pengpeng, Yue, Mengjiao, Wang, Qingbo, Liu, Bin, Liang, Shaoqin, Gan, Chengke, Weng, Jintao, Gao   +11 more
openaire   +2 more sources

The Oncogenic Splicing Factor SRSF1 Promotes p53-Dependent Senescence

Cancer Discovery, 2013
Abstract SRSF1 triggers senescence via stabilization of p53 protein as part of a RPL5–MDM2 complex.
openaire   +1 more source

TIM22 and TIM29 inhibit HBV replication by up‐regulating SRSF1 expression

Journal of Medical Virology
AbstractHepatitis B virus (HBV) infection is a serious global health problem. After the viruses infect the human body, the host can respond to the virus infection by coordinating various cellular responses, in which mitochondria play an important role. Evidence has shown that mitochondrial proteins are involved in host antiviral responses.
Lin Guo, Jia‐jun Liu, Shao‐yuan Long, Pei‐yun Wang, Shan Li, Jin‐lan Wang, Xia‐fei Wei, Jie Li, Ling Lei, Ai‐long Huang, Jie‐li Hu   +10 more
openaire   +2 more sources

AMPK affects alternative splicing via SRSF1 phosphorylation

2020
openaire   +1 more source

Control of SRSF1 by NOD2.

openaire   +1 more source