Results 11 to 20 of about 5,225 (188)

SRSF1 modulates PTPMT1 alternative splicing to regulate lung cancer cell radioresistanceResearch in context [PDF]

EBioMedicine, 2018
Background: Radioresistance is the major cause of cancer treatment failure. Additionally, splicing dysregulation plays critical roles in tumorigenesis. However, the involvement of alternative splicing in resistance of cancer cells to radiotherapy remains
Junxiu Sheng, Qingzhi Zhao, Jinyao Zhao, Wenjing Zhang, Yu Sun, Pan Qin, Yuesheng Lv, Lu Bai, Quan Yang, Lei Chen, Yangfan Qi, Ge Zhang, Lin Zhang, Chundong Gu, Xiaoqin Deng, Han Liu, Songshu Meng, Hong Gu, Quentin Liu, Judy M. Coulson, Xiaoling Li, Bing Sun, Yang Wang   +22 more
doaj   +4 more sources

AB125. The correlation of SRSF1 and survivin in prostate cancer

Translational Andrology and Urology, 2016
OBJECTIVE: To test the expression of serine/arginine rich splicing factor 1 (SRSF1) and survivin [poptosis inhibiting factor (survivin)] in prostate cancer organizations, and study their correlation with the pathological features of prostate cancer, thus put forward the new targets in the treatment of prostate cancer.
Bangming Xiao, Ping Wang
openalex   +3 more sources

Splicing factor SRSF1 is essential for homing of precursor spermatogonial stem cells in mice [PDF]

eLife
Spermatogonial stem cells (SSCs) are essential for continuous spermatogenesis and male fertility. The underlying mechanisms of alternative splicing (AS) in mouse SSCs are still largely unclear.
Longjie Sun, Zheng Lv, Xuexue Chen, Rong Ye, Shuang Tian, Chaofan Wang, Xiaomei Xie, Lu Yan, Xiaohong Yao, Yujing Shao, Sheng Cui, Juan Chen, Jiali Liu   +12 more
doaj   +2 more sources

SRSF1 Is Required for Mitochondrial Homeostasis and Thermogenic Function in Brown Adipocytes Through its Control of Ndufs3 Splicing [PDF]

Advanced Science
RNA splicing dysregulation and the involvement of specific splicing factors are emerging as common factors in both obesity and metabolic disorders. The study provides compelling evidence that the absence of the splicing factor SRSF1 in mature adipocytes ...
Ningyang Yuan, Lei Shen, Qian Peng, Rula Sha, Zhenzhen Wang, Zhiqi Xie, Xue You, Ying Feng   +7 more
doaj   +2 more sources

SRSF1-mediated alternative splicing regulates bladder cancer progression and cisplatin sensitivity through HIF1A/BNIP3/mitophagy axis [PDF]

Journal of Translational Medicine
Background Alternative splicing (AS) is consistently linked to tumor progression. SRSF1, the first identified proto-oncogene in the serine/arginine-rich splicing factor (SRSF) protein family, plays a crucial role.
Qikai Wu, Hao Yu, Huanyou Sun, Jiancheng Lv, Juntao Zhuang, Lingkai Cai, Lingjing Jiang, Yuhan Chen, Yiran Tao, Kexin Bai, Haiwei Yang, Xiao Yang, Qiang Lu   +12 more
doaj   +2 more sources

Split-APEX implicates splicing factor SRSF1 and splicing helicases in ribosomal biogenesis [PDF]

Frontiers in Molecular Biosciences
SR proteins are RNA-binding proteins with one or two RNA recognition motif (RRM)-type RNA-binding domains and a C-terminal region rich in arginine-serine dipeptides. They function in cellular processes ranging from transcription to translation.
Vasileios Paschalis, Vasileios Paschalis, Max F. K. Wills, Max F. K. Wills, Philippe De Gusmao Araujo, Philippe De Gusmao Araujo, Christian Lucas, Christian Lucas, Sumera Tubasum, Sumera Tubasum, Shijie Cui, Shijie Cui, Hesna Kara, Hesna Kara, Carlos Bueno-Alejo, Carlos Bueno-Alejo, Marina Santana-Vega, Andrea Taladriz-Sender, Zhengyun Zhao, Alexander Axer, Cyril Dominguez, Cyril Dominguez, Alasdair W. Clark, Glenn A. Burley, Andrew J. Hudson, Andrew J. Hudson, Ian C. Eperon, Ian C. Eperon   +27 more
doaj   +2 more sources

Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC

Cell Reports, 2012
The SR protein splicing factor SRSF1 is a potent proto-oncogene that is frequently upregulated in cancer. Here, we show that SRSF1 is a direct target of the transcription factor oncoprotein MYC.
Shipra Das, Olga Anczuków, Martin Akerman, Adrian R. Krainer   +3 more
doaj   +3 more sources

CircCDR1as mediates PM2.5-induced lung cancer progression by binding to SRSF1

Ecotoxicology and Environmental Safety, 2023
Research indicates that particulate matter with an aerodynamic equivalent diameter of less than or equal to 2.5 µm in ambient air may induce lung cancer progression.
Jingbin Xu, Lanyi Huang, Tuya Bao, Kaiqian Duan, Yu Cheng, Haimin Zhang, Yong Zhang, Jing Li, Qiujuan Li, Fasheng Li   +9 more
doaj   +3 more sources

PRMT1 alleviates isoprenaline-induced myocardial hypertrophy by methylating SRSF1

Acta Biochimica et Biophysica Sinica
Myocardial hypertrophy (MH) is an important factor contributing to severe cardiovascular disease. Previous studies have demonstrated that specific deletion of the protein arginine methyltransferase 1 (PRMT1) leads to MH, but the exact mechanism remains ...
Yan Zi, Zhao Wenhui, Zhao Naixin, Liu Yufeng, Yang Bowen, Wang Li, Liu Jingyi, Wang Deping, Wang Jin, Jiao Xiangying, Cao Jimin, Li Jianguo   +11 more
doaj   +3 more sources

Pur-Alpha Induces JCV Gene Expression and Viral Replication by Suppressing SRSF1 in Glial Cells. [PDF]

PLoS ONE, 2016
OBJECTIVE:PML is a rare and fatal demyelinating disease of the CNS caused by the human polyomavirus, JC virus (JCV), which occurs in AIDS patients and those on immunosuppressive monoclonal antibody therapies (mAbs).
Ilker Kudret Sariyer, Rahsan Sariyer, Jessica Otte, Jennifer Gordon   +3 more
doaj   +3 more sources