Results 21 to 30 of about 5,225 (188)

Glucocorticoids regulate the expression of Srsf1 through Hdac4/Foxc1 axis to induce apoptosis of osteoblasts [PDF]

Communications Biology
Further study of the mechanism of glucocorticoid (GC)-induced osteoblast (OB) apoptosis is highly important for the prevention and treatment of GC-induced osteoporosis and osteonecrosis.
Hong Luo, Tao Wang, Zhihong Xie, Fanchao Li, Chengyou Yang, Wentao Dong, Jianhua Wu, Qiang Wang, Fengyang Xu, Jiong Liu, Fei Zhang, Wuxun Peng   +11 more
doaj   +2 more sources

LUC7L3 is a downstream factor of SRSF1 and prevents genomic instability

Cell Insight
The RNA-binding protein LUC7L3 is the human homolog of yeast U1 small nuclear RNA (snRNA)-related splicing factor Luc7p. While the primary function of LUC7L3 as an RNA-binding protein is believed to be involved in RNA metabolism, particularly in the splicing process, its exact role and other functions are still not fully understood.
Xiaqing Zhang, Jing Guo, Xin Shi, Xin Zhou, Qiang Chen   +4 more
openalex   +4 more sources

Targeting SRSF1 improves cancer immunotherapy by dually acting on CD8+T and tumor cells [PDF]

Signal Transduction and Targeted Therapy
Serine arginine-rich splicing factor 1 (SRSF1) is a key oncogenic splicing factor in various cancers, promoting abnormal gene expression through post-translational regulation.
Gui-Qi Zhu, Zheng Tang, Tian-Hao Chu, Biao Wang, Shi-Ping Chen, Chen-Yang Tao, Jia-Liang Cai, Rui Yang, Wei-Feng Qu, Yi Wang, Qian-Fu Zhao, Run Huang, Meng-Xin Tian, Yuan Fang, Jun Gao, Xiao-Ling Wu, Jian Zhou, Wei-Ren Liu, Zhi Dai, Ying-Hong Shi, Jia Fan   +20 more
doaj   +2 more sources

Splicing factor SRSF1 attenuates cardiomyocytes apoptosis via regulating alternative splicing of Bcl2L12

Cell & Bioscience
Background Aberrant alternative splicing (AS) events, triggered by the alterations in serine/arginine splicing factor 1 (SRSF1), a member of the SR protein family, have been implicated in various pathological processes.
Yilin Xie, Zhenbo Yang, Wenxian Chen, Changsheng Zhong, Mengyang Li, Lei Zhang, Ting Cheng, Qin Deng, Huifang Wang, Jin Ju, Zhimin Du, Haihai Liang   +11 more
doaj   +3 more sources

Mechanism of LINC00958 in ferroptosis of breast cancer through the SRSF1/GPX4 axis [PDF]

Hereditas
Background Breast cancer (BC) is the most common cancer among women. Ferroptosis is a novel iron-dependent form of cell death and affects cancer development.
Shan Wang, Xinlu Liu, Xiaoli Hou, Wei Sun, Jiajie Chen, Yasen Cao, Hong Cheng   +6 more
doaj   +2 more sources

Exploring Splicing-Energy Axis Associations to Diet and Longevity. [PDF]

Aging Cell
Caloric restriction improves mitochondrial function, while a low‐protein, high‐carbohydrate diet improves pre‐RNA splicing, as shown by Brandon et al. Despite employing distinct pathways, both dietary strategies enhance the energy‐splicing axis to increase longevity. ABSTRACT There is increasing evidence that nutrient composition, even without lowering
Donega S, Gorospe M, Ferrucci L.
europepmc   +2 more sources

SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer

Signal Transduction and Targeted Therapy, 2021
Alternative splicing is a critical process to generate protein diversity. However, whether and how alternative splicing regulates autophagy remains largely elusive.
Yuesheng Lv, Wenjing Zhang, Jinyao Zhao, Bing Sun, Yangfan Qi, Haoyu Ji, Chaoqun Chen, Jinrui Zhang, Junxiu Sheng, Taishu Wang, Daniel Dominguez, Han Liu, Quentin Liu, Songshu Meng, Xiaoling Li, Yang Wang   +15 more
doaj   +1 more source

SRSF1-mediated alternative splicing is required for spermatogenesis

International Journal of Biological Sciences, 2023
Alternative splicing (AS) plays significant roles in a multitude of fundamental biological activities. AS is prevalent in the testis, but the regulations of AS in spermatogenesis is only little explored. Here, we report that Serine/arginine-rich splicing factor 1 (SRSF1) plays critical roles in alternative splicing and male reproduction. Male germ cell-
Lei, Wen-Long, Li, Yuan-Yuan, Du, Zongchang, Su, Ruibao, Meng, Tie-Gang, Ning, Yan, Hou, Guanmei, Schatten, Heide, Wang, Zhen-Bo, Han, Zhiming, Sun, Fei, Qian, Wei-Ping, Liu, Chenli, Sun, Qing-Yuan   +13 more
openaire   +2 more sources

SRSF1-Regulated Alternative Splicing in Breast Cancer [PDF]

Molecular Cell, 2015
Splicing factor SRSF1 is upregulated in human breast tumors, and its overexpression promotes transformation of mammary cells. Using RNA-seq, we identified SRSF1-regulated alternative splicing (AS) targets in organotypic three-dimensional MCF-10A cell cultures that mimic a context relevant to breast cancer.
Anczuków, Olga, Akerman, Martin, Cléry, Antoine, Wu, Jie, Shen, Chen, Shirole, Nitin H., Raimer, Amanda, Sun, Shuying, Jensen, Mads A., Hua, Yimin, Allain, Frédéric H.-T., Krainer, Adrian R.   +11 more
openaire   +2 more sources

Phosphorylation of SRSF1 is modulated by replicational stress [PDF]

Nucleic Acids Research, 2011
DNA ligase I-deficient 46BR.1G1 cells show a delay in the maturation of replicative intermediates resulting in the accumulation of single- and double-stranded DNA breaks. As a consequence the ataxia telangiectasia mutated protein kinase (ATM) is constitutively phosphorylated at a basal level.
Leva V, Giuliano S, Bardoni A, Camerini S, Crescenzi M, Lisa A, Biamonti G, Montecucco A   +7 more
openaire   +2 more sources