Results 31 to 40 of about 5,225 (188)
Frontiers in Immunology, 2022 The underlying mechanisms of thymocyte development and lineage determination remain incompletely understood, and the emerging evidences demonstrated that RNA binding proteins (RBPs) are deeply involved in governing T cell fate in thymus.
Ce Ji +15 more
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Splicing factor SRSF1 promotes breast cancer progression via oncogenic splice switching of PTPMT1
Journal of Experimental & Clinical Cancer Research, 2021 Background Intensive evidence has highlighted the effect of aberrant alternative splicing (AS) events on cancer progression when triggered by dysregulation of the SR protein family.
Jun-Xian Du +12 more
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Cell Reports, 2023 Summary: PRMT1 plays a vital role in breast tumorigenesis; however, the underlying molecular mechanisms remain incompletely understood. Herein, we show that PRMT1 plays a critical role in RNA alternative splicing, with a preference for exon inclusion ...
Wen-juan Li +12 more
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Splicing factor SRSF1 is essential for CD8 T cell function and host antigen-specific viral immunity
Frontiers in Immunology, 2022 Cytotoxic CD8 T cells are crucial for the host antigen-specific immune response to viral pathogens. Here we report the identification of an essential role for the serine/arginine-rich splicing factor (SRSF) 1 in CD8 T cell homeostasis and function ...
Ignacio Juarez +6 more
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The Splicing Factor SRSF1 as a Marker for Endothelial Senescence [PDF]
Frontiers in Physiology, 2012 Aging is the major risk factor per se for the development of cardiovascular diseases. The senescence of the endothelial cells (ECs) that line the lumen of blood vessels is the cellular basis for these age-dependent vascular pathologies, including atherosclerosis and hypertension.
Blanco, Francisco Javier +1 more
openaire +3 more sources
The translational landscape of the splicing factor SRSF1 and its role in mitosis
eLife, 2014 The shuttling serine/arginine rich (SR) protein SRSF1 (previously known as SF2/ASF) is a splicing regulator that also activates translation in the cytoplasm.
Magdalena M Maslon +4 more
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Cell Death Discovery, 2021 Steroid receptor RNA activator 1 (SRA1) has been described as a novel transcriptional co-activator that affects the migration of cancer cells. Through RT-PCR, we identified that skipping exon 3 of SRA1 produces two isoforms, including the truncated short
Sijia Lei +15 more
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Postępy Higieny i Medycyny Doświadczalnej, 2017 SRSF1 jest wielofunkcyjnym białkiem biorącym udział w procesach związanych z metabolizmem RNA. Następstwem zaburzeń ekspresji SRSF1, obserwowanych w wielu typach nowotworów, są nieprawidłowości w składaniu pre-mRNA, zmiany stabilności transkryptów i poziomu translacji onkogenów oraz genów supresorowych.
Elżbieta, Sokół +2 more
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HIV-1 transcription is regulated by splicing factor SRSF1 [PDF]
Nucleic Acids Research, 2014 Efficient transcription of the HIV-1 genome is regulated by Tat, which recruits P-TEFb from the 7SK small nuclear ribonucleoprotein (snRNP) and other nucleoplasmic complexes to phosphorylate RNA polymerase II and other factors associated with the transcription complex.
Paz, S., Krainer, A. R., Caputi, M.
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SRSF1 inhibition of HIV-1 gene expression
Oncotarget, 2015 The treatment of HIV-1 infected patients is mostly based on compounds that directly target the activity of proteins coded by the virus. However, the viral genome mutates at a rapid rate, generating drug resistant strains, hence the need for novel drugs to outpace the adaptive mechanisms of the virus.
Sean, Paz, Massimo, Caputi
openaire +2 more sources