Results 41 to 50 of about 5,225 (188)

Increased Expression of SRSF1 Predicts Poor Prognosis in Multiple Myeloma

Journal of Oncology, 2023
Background. Multiple myeloma (MM) is a clonal plasma cell disorder which still lacks sufficient prognostic factors. The serine/arginine-rich splicing factor (SRSF) family serves as an important splicing regulator in organ development. Among all members, SRSF1 plays an important role in cell proliferation and renewal. However, the role of SRSF1 in MM is
Jiawei Zhang, Zanzan Wang, Kailai Wang, Dijia Xin, Luyao Wang, Yili Fan, Yang Xu   +6 more
openaire   +2 more sources

SRSF1 Prevents DNA Damage and Promotes Tumorigenesis through Regulation of DBF4B Pre-mRNA Splicing

Cell Reports, 2017
Summary: Dysregulated alternative splicing events have been implicated in many types of cancer, but the underlying molecular mechanisms remain unclear. Here, we observe that the splicing factor SRSF1 regulates DBF4B exon6 splicing by specifically binding
Linlin Chen, Chunling Luo, Lei Shen, Yuguo Liu, Qianqian Wang, Chang Zhang, Ruochen Guo, Yanan Zhang, Zhiqin Xie, Ning Wei, Wenwu Wu, Jun Han, Ying Feng   +12 more
doaj   +1 more source

Correlation of SRSF1 and PRMT1 expression with clinical status of pediatric acute lymphoblastic leukemia

Journal of Hematology & Oncology, 2012
Background Acute lymphoblastic leukemia (ALL) is the most frequently-occurring malignant neoplasm in children, but the pathogenesis of the disease remains unclear.
Zou Limin, Zhang Han, Du Chaohao, Liu Xiao, Zhu Shanshan, Zhang Wei, Li Zhigang, Gao Chao, Zhao Xiaoxi, Mei Mei, Bao Shilai, Zheng Huyong   +11 more
doaj   +1 more source

Structure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing

Nature Communications, 2021
SRSF1 is an oncoprotein that plays important roles in RNA metabolism. We reveal the structure of the human SRSF1 RRM1 bound to RNA, and propose a bimodal mode of interaction of the protein with RNA. A single mutation in RRM1 changed SRSF1 specificity for
Antoine Cléry, Miroslav Krepl, Cristina K. X. Nguyen, Ahmed Moursy, Hadi Jorjani, Maria Katsantoni, Michal Okoniewski, Nitish Mittal, Mihaela Zavolan, Jiri Sponer, Frédéric H.-T. Allain   +10 more
doaj   +1 more source

Splicing factor SRSF1 controls T cell hyperactivity and systemic autoimmunity [PDF]

Journal of Clinical Investigation, 2019
Systemic lupus erythematosus (SLE) is a devastating autoimmune disease in which hyperactive T cells play a critical role. Understanding molecular mechanisms underlying the T cell hyperactivity will lead to identification of specific therapeutic targets.
Takayuki Katsuyama, Hao Li, Denis Comte, George C. Tsokos, Vaishali R. Moulton   +4 more
openaire   +2 more sources

SRSF1 regulates primordial follicle formation and number determination during meiotic prophase I

BMC Biology, 2023
Background Ovarian folliculogenesis is a tightly regulated process leading to the formation of functional oocytes and involving successive quality control mechanisms that monitor chromosomal DNA integrity and meiotic recombination.
Longjie Sun, Zheng Lv, Xuexue Chen, Chaofan Wang, Pengbo Lv, Lu Yan, Shuang Tian, Xiaomei Xie, Xiaohong Yao, Jingjing Liu, Zhao Wang, Haoshu Luo, Sheng Cui, Jiali Liu   +13 more
doaj   +1 more source

SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps

Frontiers in Immunology, 2022
Efficient HIV-1 replication depends on balanced levels of host cell components including cellular splicing factors as the family of serine/arginine-rich splicing factors (SRSF, 1–10).
Helene Sertznig, Fabian Roesmann, Alexander Wilhelm, Delia Heininger, Barbara Bleekmann, Carina Elsner, Mario Santiago, Jonas Schuhenn, Zehra Karakoese, Yvonne Benatzy, Ryan Snodgrass, Stefan Esser, Kathrin Sutter, Ulf Dittmer, Marek Widera, Marek Widera   +15 more
doaj   +1 more source

SRSF1 (serine/arginine-rich splicing factor 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on SRSF1 (serine/arginine-rich splicing factor 1), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +2 more sources

Splicing factor SRSF1 negatively regulates alternative splicing of MDM2 under damage [PDF]

Nucleic Acids Research, 2015
Genotoxic stress induces alternative splicing of the oncogene MDM2 generating MDM2-ALT1, an isoform attributed with tumorigenic properties. However, the mechanisms underlying this event remain unclear. Here we explore MDM2 splicing regulation by utilizing a novel minigene that mimics endogenous MDM2 splicing in response to UV and cisplatinum-induced ...
Comiskey, Daniel F., Jacob, Aishwarya G., Singh, Ravi K., Tapia-Santos, Aixa S., Chandler, Dawn S.   +4 more
openaire   +2 more sources

The Clinical Role of SRSF1 Expression in Cancer: A Review of the Current Literature

Applied Sciences, 2022
Background: SFRS1 is a member of the splicing factor protein family. Through a specific sequence of alteration, SRSF1 can move from the cytoplasm to the nucleus where it can work autonomously as a splicing activator, or as a silencer when interacting ...
Arturo Lo Giudice, Maria Giovanna Asmundo, Giuseppe Broggi, Sebastiano Cimino, Giuseppe Morgia, Ettore Di Trapani, Stefano Luzzago, Gennaro Musi, Matteo Ferro, Ottavio de Cobelli, Giorgio I. Russo   +10 more
doaj   +1 more source