Results 51 to 60 of about 5,225 (188)

USP15 and USP4 facilitate lung cancer cell proliferation by regulating the alternative splicing of SRSF1

Cell Death Discovery, 2022
The deubiquitinating enzyme USP15 is implicated in several human cancers by regulating different cellular processes, including splicing regulation. However, the underlying molecular mechanisms of its functional relevance and the successive roles in ...
Tanuza Das, Eun-Young Lee, Hye Jin You, Eunice EunKyeong Kim, Eun Joo Song   +4 more
doaj   +1 more source

SRSF1 inhibits HBV replication by enhancing the stability of P53 in cell models

陆军军医大学学报
‍Objective‍　‍To investigate the effect and underlying mechanism of serine and arginine rich splicing factor 1 (SRSF1) on the replication of hepatitis B virus (HBV).
LIU Jiajun, LIU Jiajun, LONG Shaoyuan , HU Jieli   +3 more
doaj   +1 more source

Bioinformatics analysis of SRSF1‑controlled gene networks in colorectal cancer

Oncology Letters, 2017
Colorectal cancer is the third most common type of cancer and the fourth leading cause of cancer-associated mortality worldwide. Serine/arginine-rich splicing factor 1 (SRSF1) is a well-characterized oncogenic factor that promotes tumorigenesis by controlling a number of alternative splicing events.
Sheng, Junxiu, Zhao, Jinyao, Xu, Qiuhong, Wang, Linlin, Zhang, Wenjing, Zhang, Yang   +5 more
openaire   +3 more sources

Immune suppression of JC virus gene expression is mediated by SRSF1 [PDF]

Journal of NeuroVirology, 2016
Progressive multifocal leukoemcephalopathy (PML) is a fatal demyelinating disease caused by the human neurotropic JC virus (JCV). JCV infects the majority of the human population during childhood and establishes a latent/persistent life-long infection.
Rahsan, Sariyer, Francesca Isabella, De-Simone, Jennifer, Gordon, Ilker Kudret, Sariyer   +3 more
openaire   +2 more sources

Ascites circRNA ASCOR Drives Platinum Resistance of High‐Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation

Advanced Science, EarlyView.
High‐grade serous ovarian carcinoma (HGSOC) is plagued by platinum resistance, with malignant ascites closely linked to poor outcomes. Here, we identify ASCOR, a circRNA enriched in ascites small extracellular vesicles (sEVs) from platinum‐resistant HGSOC patients, as a predictor of poor survival. ASCOR enhances platinum resistance in vitro and in vivo
Hanyuan Liu, Chenchen Zhu, Xuelin Yao, Yi Liu, Jing Zhu, Yuebo Li, Hanjie Xu, Cheng Peng, Ge Shan, Liang Chen, Ying Zhou   +10 more
wiley   +1 more source

Altered VEGF Splicing Isoform Balance in Tumor Endothelium Involves Activation of Splicing Factors Srpk1 and Srsf1 by the Wilms’ Tumor Suppressor Wt1

Cells, 2019
Angiogenesis is one hallmark of cancer. Vascular endothelial growth factor (VEGF) is a known inducer of angiogenesis. Many patients benefit from antiangiogenic therapies, which however have limitations.
Kay-Dietrich Wagner, Mounir El Maï, Michael Ladomery, Tareg Belali, Nathalie Leccia, Jean-François Michiels, Nicole Wagner   +6 more
doaj   +1 more source

Splicing factor SRSF1 promotes gliomagenesis via oncogenic splice-switching of MYO1B [PDF]

Journal of Clinical Investigation, 2019
Abnormal alternative splicing (AS) caused by alterations to splicing factors contributes to tumor progression. Serine/arginine splicing factor 1 (SRSF1) has emerged as a key oncodriver in numerous solid tumors, leaving its roles and mechanisms largely obscure in glioma.
Xuexia Zhou, Run Wang, Xuebing Li, Lin Yu, Dan Hua, Cuiyun Sun, Cuijuan Shi, Wenjun Luo, Chun Rao, Zhendong Jiang, Ying Feng, Qian Wang, Shizhu Yu   +12 more
openaire   +2 more sources

Dysregulation of U12‐Type Splicing in Lupus Neutrophils

Arthritis &Rheumatology, Accepted Article.
Abstract. Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and post‐transcriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron ...
Luz P. Blanco, Binod Regmi, Carmelo Carmona‐Rivera, Yudong Liu, Xiantao Wang, Philip M. Carlucci, Monica M. Jackson, Zerai Manna, Sarfaraz Hasni, Markus Hafner, Hong‐Wei Sun, Mariana J. Kaplan   +11 more
wiley   +1 more source

Deletion of RBMX RGG/RG motif in Shashi-XLID syndrome leads to aberrant p53 activation and neuronal differentiation defects

Cell Reports, 2021
Summary: RNA-binding proteins play important roles in X-linked intellectual disability (XLID). In this study, we investigate the contribution of the XLID-associated RBMX in neuronal differentiation.
Ting Cai, Jessica K. Cinkornpumin, Zhenbao Yu, Oscar D. Villarreal, William A. Pastor, Stéphane Richard   +5 more
doaj   +1 more source

Dynamic Distribution and Interaction of the Arabidopsis SRSF1 Subfamily Splicing Factors [PDF]

Plant Physiology, 2015
Abstract Ser/Arg-rich (SR) proteins are essential nucleus-localized splicing factors. Our prior studies showed that Arabidopsis (Arabidopsis thaliana) RSZ22, a homolog of the human SRSF7 SR factor, exits the nucleus through two pathways, either dependent or independent on the XPO1 receptor.
Stankovic, Nancy, Schloesser, Marie, Joris, Marine, Sauvage, Eric, Hanikenne, Marc, Motte, Patrick   +5 more
openaire   +3 more sources