Results 61 to 70 of about 5,225 (188)

OsFKBP20‐1b stabilizes OsUPF1 and OsUPF2 to promote the degradation of aberrant mRNAs during dehydration stress

Journal of Integrative Plant Biology, EarlyView.
The rice protein OsFKBP20‐1b protects key RNA‐surveillance factors from breakdown, so they can better eliminate defective messages. This RNA quality‐control boost reduces errors and helps plants survive drought, revealing a link between RNA control and drought tolerance.
Haemyeong Jung, Hyun Ji Park, Seung Hee Jo, Ki‐Hong Jung, Choonkyun Jung, Hye Sun Cho   +5 more
wiley   +1 more source

hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene. [PDF]

PLoS ONE, 2011
Exon 11 of the insulin receptor gene (INSR) is alternatively spliced in a developmentally and tissue-specific manner. Linker scanning mutations in a 5' GA-rich enhancer in intron 10 identified AGGGA sequences that are important for enhancer function ...
Indrani Talukdar, Supriya Sen, Rodolfo Urbano, James Thompson, John R Yates, Nicholas J G Webster   +5 more
doaj   +1 more source

Overexpression of hsa_circ_0001445 reverses oxLDL‑induced inhibition of HUVEC proliferation via SRSF1

Molecular Medicine Reports, 2021
Atherosclerosis is a primary cause of multiple types of cardiovascular disease, including myocardial infarction. In addition, injury of human umbilical vein endothelial cells (HUVECs) can lead to the development of atherosclerosis. Circular (circ)RNAs participate in atherosclerosis.
Liang, Guiying, Chen, Sihua, Xin, Sha, Dong, Liang   +3 more
openaire   +3 more sources

Proteomic Epithelial‐To‐Mesenchymal Transition Signature in Fetoplacental Small Extracellular Vesicles of Early‐Onset Preeclampsia

Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.
ABSTRACT Preeclampsia (PE), a hypertensive disorder in pregnancy, is linked to placental vascular remodelling, increasing risks of foetal growth restriction and long‐term offspring health problems. The role of fetoplacental endothelial cell‐derived extracellular vesicles (EVs) in PE remains underexplored.
Michaela Stoiber, Monika Horvat Mercnik, Birgit Hirschmugl, Barbara Darnhofer, Dominique Pernitsch, Barbara Leopold‐Posch, Ursula Hiden, Dagmar Kolb, Christian Wadsack   +8 more
wiley   +1 more source

Expression Profile of Three Splicing Factors in Pleural Cells Based on the Underlying Etiology and Its Clinical Values in Patients with Pleural Effusion

Translational Oncology, 2018
Splicing factors (SFs) are involved in oncogenesis or immune modulation, the common underlying processes giving rise to pleural effusion (PE). The expression profiles of three SFs (HNRNPA1, SRSF1, and SRSF3) and their clinical values have never been ...
A-Lum Han, Hak-Ryul Kim, Keum-Ha Choi, Jae-won Ryu, Ki-Eun Hwang, Hong-Seob So, Min-Cheol Park, Mengyu Zhu, Yuya Huang, Young-Jin Lee, Do-Sim Park   +10 more
doaj   +1 more source

SRSF1 mediates cytokine-induced impaired imatinib sensitivity in chronic myeloid leukemia [PDF]

Leukemia, 2020
Patients with chronic myeloid leukemia (CML) who are treated with tyrosine kinase inhibitors (TKIs) experience significant heterogeneity regarding depth and speed of responses. Factors intrinsic and extrinsic to CML cells contribute to response heterogeneity and TKI resistance.
Sinnakannu, Joanna R, Lee, Kian Leong, Cheng, Shanshan, Li, Jia, Yu, Mengge, Tan, Siew Peng, Ong, Clara Chong Hui, Li, Huihua, Than, Hein, Anczuków, Olga, Krainer, Adrian R, Roca, Xavier, Rozen, Steven G, Iqbal, Jabed, Yang, Henry, Chuah, Charles, Ong, Sin Tiong   +16 more
openaire   +3 more sources

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source

CircRPAP2 regulates the alternative splicing of PTK2 by binding to SRSF1 in breast cancer

Cell Death Discovery, 2022
Breast cancer is the most commonly diagnosed malignant tumor and the second-highest cause of cancer-related deaths in women worldwide. Circular RNAs (circRNAs) are associated with the development of numerous cancers, including breast cancer.
Yunhe Yu, Lin Fang
doaj   +1 more source

Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem, Atif Ali, Wajid Ali, Yuying Cheng, Zhibin Yan, Chaoyi Xia, Chenguang Liu, Caiyun Fu, Yiren Hu, Xi Wang   +9 more
wiley   +1 more source

Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function

eLife, 2021
Shuttling RNA-binding proteins coordinate nuclear and cytoplasmic steps of gene expression. The SR family proteins regulate RNA splicing in the nucleus and a subset of them, including SRSF1, shuttles between the nucleus and cytoplasm affecting post ...
Fiona Haward, Magdalena M Maslon, Patricia L Yeyati, Nicolas Bellora, Jan N Hansen, Stuart Aitken, Jennifer Lawson, Alex von Kriegsheim, Dagmar Wachten, Pleasantine Mill, Ian R Adams, Javier F Caceres   +11 more
doaj   +1 more source