Results 71 to 80 of about 5,225 (188)

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

SRSF1 Is Crucial for Maintaining Satellite Cell Homeostasis During Skeletal Muscle Growth and Regeneration

Journal of Cachexia, Sarcopenia and Muscle
Background The splicing factor SRSF1 emerges as a mater regulator of cell proliferation, displaying high expression in actively proliferative satellite cells (SCs).
Zhenzhen Wang, Qian Peng, Zhige Zhang, Xue You, Huimin Duan, Rula Sha, Ningyang Yuan, Zhigang Li, Zhiqin Xie, Jun Han, Ying Feng   +10 more
doaj   +1 more source

Mechanism of Nonsense-Mediated mRNA Decay Stimulation by Splicing Factor SRSF1

Cell Reports, 2018
The splicing factor SRSF1 promotes nonsense-mediated mRNA decay (NMD), a quality control mechanism that degrades mRNAs with premature termination codons (PTCs). Here we show that transcript-bound SRSF1 increases the binding of NMD factor UPF1 to mRNAs while in, or associated with, the nucleus, bypassing UPF2 recruitment and promoting NMD.
Aznarez, Isabel, Nomakuchi, Tomoki T., Tetenbaum-Novatt, Jaclyn, Rahman, Mohammad Alinoor, Fregoso, Oliver, Rees, Holly, Krainer, Adrian R.   +6 more
openaire   +2 more sources

Proteomic insights into the invasiveness and tumor progression of non‐functioning pituitary adenomas: A scoping review

Journal of Neuroendocrinology, Volume 38, Issue 3, March 2026.
Abstract Nonfunctioning pituitary adenomas (NFPAs) are common intracranial tumors that, despite being histologically benign, can exhibit invasive growth, as well as postoperative tumor progression. Surgical resection is the primary treatment of choice; however, residual tumor tissue is frequently observed, with between 30% and 50% of these cases ...
Thomas Skoglund, Linus Köster, Annika Thorsell, Oskar Ragnarsson, Gudmundur Johannsson, Tobias Hallén   +5 more
wiley   +1 more source

The Immunohistochemical Expression of the Serine and Arginine-Rich Splicing Factor 1 (SRSF1) Is a Predictive Factor of the Recurrence of Basal Cell Carcinoma: A Preliminary Study on a Series of 52 Cases

Medicina, 2022
Background and Objectives: Basal cell carcinomas (BCCs) are the most frequent skin tumors; although they usually exhibit a good prognosis, it has been reported that there is a 2–8% rate of local recurrence of surgically-excised BCCs, even in the presence
Giuseppe Broggi, Davide Barbagallo, Francesco Lacarrubba, Anna Elisa Verzì, Giuseppe Micali, Michele Purrello, Rosario Caltabiano   +6 more
doaj   +1 more source

MIR155HG Knockdown Inhibited the Progression of Cervical Cancer by Binding SRSF1.

OncoTargets and therapy, 2020
As the fourth most common cancer among women worldwide, cervical cancer lead to 311,000 deaths in 2018. Although the treatments have been developed, the survival rate of cervical cancer remains unsatisfactory. In this study, we aimed to identify differentially expressed lncRNAs (DEIncRNAs) between cervical cancer and adjacent normal tissues using ...
Shen,Ling, Li,Yuancheng, Hu,Guiying, Huang,Yihong, Song,Xinli, Yu,Shun, Xu,Xiaoyuan   +6 more
openaire   +3 more sources

The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu, Lingli Shi, Aifang Lu, Lijuan Cui, Haiqing Qian, Jiahui Wang, Mengyu Tang, Lili Zhu, Lihong Wang   +8 more
wiley   +1 more source

CCL21 activation of the MALAT1/SRSF1/mTOR axis underpins the development of gastric carcinoma

Journal of Translational Medicine, 2021
Background As a significant cause of malignancy mortality, gastric carcinoma (GC) has been well documented to be an often-fatal diagnosis. Despite the limitations of effective therapy, immunotherapy has emerged as a promising therapeutic approach capable
Qianmei Fu, Xiaohong Tan, Huaming Tang, Jijiang Liu   +3 more
doaj   +1 more source

T Cell Activation Regulates CD6 Alternative Splicing by Transcription Dynamics and SRSF1 [PDF]

The Journal of Immunology, 2014
Abstract The T cell-surface glycoprotein CD6 is a modulator of cellular responses and has been implicated in several autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and psoriasis. During Ag presentation, CD6 is targeted to the immunological synapse in a ligand binding-dependent manner, in which CD6 domain 3 directly
da Glória, Vânia G., Martins de Araújo, Mafalda, Mafalda Santos, Ana, Leal, Rafaela, de Almeida, Sérgio F., Carmo, Alexandre M., Moreira, Alexandra   +6 more
openaire   +4 more sources

Generation of functional noncanonical donor splice sites by +2T variants in breast cancer susceptibility genes: impact on clinical interpretation

The Journal of Pathology, Volume 268, Issue 2, Page 150-163, February 2026.
Abstract Splicing dysregulation is a relevant mechanism of pathogenicity for variants in disease susceptibility genes. Variants affecting the critical intronic +1 and +2 GT nucleotides of the 5’ splice sites (5'ss) are generally strong indicators of pathogenicity.
Inés Llinares‐Burguet, Lara Sanoguera‐Miralles, Elena Bueno‐Martínez, Alicia García‐Álvarez, Alberto Valenzuela‐Palomo, Pedro Pérez‐Segura, Miguel de la Hoya, Eladio A Velasco‐Sampedro   +7 more
wiley   +1 more source