Results 81 to 90 of about 5,225 (188)

hnRNPU Safeguards Oocyte Development and Female Fertility via Regulation of Alternative Splicing

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Heterogeneous nuclear ribonucleoprotein U (hnRNPU) is essential for oocyte development and female fertility. Oocyte‐specific deletion of Hnrnpu leads to follicular arrest, impaired meiotic maturation, mitochondrial dysfunction, and infertility.
Jinmei Li, Bei Chen, Yujiao Wen, Yanqing Wu, Kuan Liu, Jingshou Chen, Shuangqi Wang, Shenglei Feng, Juan Dong   +8 more
wiley   +1 more source

Characterization of hepatocyte‐specific SRSF1 (SF2/ASF) knockout mice

The FASEB Journal, 2012
Alternative splicing is widely believed to have a major impact on almost all biological processes since it increases proteome complexity and thereby controls protein function. SRSF1 (SF2/ASF) is a member of the SR protein family, which are essential for constitutive splicing and fulfilling regulatory functions in alternative ...
Magda Langiewicz, Supriya Sen, Nicholas J Webster   +2 more
openaire   +1 more source

SRSF1 RNA Recognition Motifs Are Strong Inhibitors of HIV-1 Replication [PDF]

Journal of Virology, 2015
ABSTRACT Replication of the integrated HIV-1 genome is tightly regulated by a series of cellular factors. In previous work we showed that transactivation of the HIV-1 promoter is regulated by the cellular splicing factor SRSF1. Here we report that SRSF1 can downregulate the replication of B, C, and D subtype viruses by >200-fold in a cell ...
Sean, Paz, Michael L, Lu, Hiroshi, Takata, Lydie, Trautmann, Massimo, Caputi   +4 more
openaire   +2 more sources

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Splicing factor SRSF1 is indispensable for regulatory T cell homeostasis and function [PDF]

, 2021
Takayuki Katsuyama, Vaishali R. Moulton
openalex   +1 more source

Genetic Evidence Reveals Causal Effect of Circulating Proteome on Random Glucose: A Mendelian Randomization Study

Journal of Diabetes Research, Volume 2026, Issue 1, 2026.
Background Random glucose (RG) testing provides greater flexibility and convenience, enabling real‐time evaluation of blood glucose levels without the need to consider recent dietary intake. This study was aimed at identifying drug targets using the evidence from circulating proteins associated with RG from genome‐wide association studies (GWASs ...
Ziyuan Shen, Xing Xing, Xiaoyue Zhang, Jianan Zhu, Yining Wang, Guoqi Cai, Marie Gilbert Majella Alphonse   +6 more
wiley   +1 more source

Retracted: lncRNA NUTM2A‐AS1 Targets the SRSF1/Trim37 Signaling Pathway to Promote the Proliferation and Invasion of Breast Cancer [PDF]

, 2023
Computational and Mathematical Methods in Medicine
openalex   +1 more source

Isoform Switching Regulates the Response to Ionizing Radiation Through SRSF1

International Journal of Radiation Oncology*Biology*Physics
This study investigated how isoform switching affects the cellular response to ionizing radiation (IR), an understudied area despite its relevance to radiation therapy in cancer treatment. We aimed to identify changes in transcript isoform expression post-IR exposure and the proteins mediating these changes, with a focus on their potential to modulate ...
Majd Abdulghani, Niema B. Razavian, Joshua T. Burdick, Enric Domingo, Vivian G. Cheung, Timothy C. Humphrey   +5 more
openaire   +2 more sources

Histone lactylation‐mediated up‐regulation of IGF2BP2 enhances ferroptosis resistance via Nrf2 in colorectal cancer

Clinical and Translational Medicine, Volume 15, Issue 12, December 2025.
In the lactate‐rich tumor microenvironment, p300‐mediated H3K18la epigenetically activates IGF2BP2 transcription. The IGF2BP2 protein then stabilizes Nrf2 mRNA in the cytoplasm, leading to increased Nrf2 levels. This axis simultaneously confers ferroptosis resistance to cancer cells and promotes M2 macrophage polarization, fostering a malignant ...
Jin‐Feng Zhu, Da‐Peng Guo, Hai‐Na Lv, Zong‐Yu Liang, Jing Song, Wei Zeng   +5 more
wiley   +1 more source

Genome‐wide CRISPR screen reveals an uncharacterized spliceosome regulator as new candidate immunotherapy target

iMeta, Volume 4, Issue 6, December 2025.
This study identifies the uncharacterized gene C9ORF50 as a novel regulator of immune evasion. Functioning as an intrinsically disordered protein, C9ORF50 drives liquid‐liquid phase separation to facilitate spliceosome assembly and maintain RNA splicing fidelity.
Tong Shao, Chuanyang Liu, Jingyu Kuang, Sisi Xie, Ying Qu, Yingying Li, Lulu Zhang, Fangzhou Liu, Yanhua Qi, Tao Hou, Ming Li, Sujuan Zhang, Yu Liu, Zhixiang Yuan, Jiali Liu, Yanming Hu, Jingyang Wang, Chenghu Song, Shaowei Zhang, Lingyun Zhu, Jianzhong Shao, Aifu Lin, Wenjun Mao, Guangchuan Wang, Lvyun Zhu   +24 more
wiley   +1 more source