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Cellular and Molecular Life Sciences (CMLS), 1999
The mammalian sex-determining gene, SRY, was identified by positional cloning approximately 10 years ago. Since its discovery, intense research into this gene has been directed on two main fronts: elucidation of its function in development of the testis and examination of its singular evolutionary history.
M J, O'Neill, R J, O'Neill
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The mammalian sex-determining gene, SRY, was identified by positional cloning approximately 10 years ago. Since its discovery, intense research into this gene has been directed on two main fronts: elucidation of its function in development of the testis and examination of its singular evolutionary history.
M J, O'Neill, R J, O'Neill
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Human Molecular Genetics, 1993
SRY encodes the Y-linked testis-determining factor in humans. A predominant 900 bp transcript originates from a single exon and encompasses the putative SRY coding sequence. We show that in human adult testis SRY transcription involves multiple start sites.
C, Clépet +5 more
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SRY encodes the Y-linked testis-determining factor in humans. A predominant 900 bp transcript originates from a single exon and encompasses the putative SRY coding sequence. We show that in human adult testis SRY transcription involves multiple start sites.
C, Clépet +5 more
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Cell Biology International, 1996
AbstractThe precise location of the SRY gene on the human Y chromosome has been revealed through studies of sex reversal cases involving deletion, cross‐linking and mutations of the SRY gene. Its DNA sequence and mechanism of action are being understood.
V C, Shah, V, Smart
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AbstractThe precise location of the SRY gene on the human Y chromosome has been revealed through studies of sex reversal cases involving deletion, cross‐linking and mutations of the SRY gene. Its DNA sequence and mechanism of action are being understood.
V C, Shah, V, Smart
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Trends in Endocrinology & Metabolism, 1993
SRY was identified in an attempt to clone the mammalian testisdetermining factor. Evidence in the form of sex-reversing mutations and mouse transgenesis experiments indicates that SRY is the testis-determining factor. The cloning of this gene marks the end of the beginning of our understanding of sex determination.
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SRY was identified in an attempt to clone the mammalian testisdetermining factor. Evidence in the form of sex-reversing mutations and mouse transgenesis experiments indicates that SRY is the testis-determining factor. The cloning of this gene marks the end of the beginning of our understanding of sex determination.
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Sry, more than testis determination?
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2011The Sry locus on the mammalian Y chromosome is the developmental switch responsible for testis determination. Inconsistent with this important function, the Sry locus is transcribed in adult males at times and in tissues not involved with testis determination. Sry is expressed in multiple tissues of the peripheral and central nervous system.
Monte E, Turner +3 more
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SRY-related genes in Xenopus oocytes
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1996SRY-related genes are known as Sox (Sry-box) genes. Two Sox cDNAs from Xenopus oocytes were analyzed. The deduced product of the Xenopus Sox gene (xSox-11) consisted of the standard domains of an HMG box, glycine/alanine-rich region and glutamic acid/aspartic acid-rich region and may be involved in the control of transcription. The other Sox gene (xSox-
S, Miyata, K, Miyashita, Y, Hosoyama
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46,XX SRY-Negative True Hermaphrodite Siblings
Urology, 2009The sex-determining region on the Y chromosome (SRY) gene guides male sexual development. However, individuals with sex reversal syndrome (46,XX males and 46,XX true hermaphrodites) lack the SRY gene and yet can still develop testes. We present 2 siblings with XX true hermaphroditism.
Faith Y, Dorsey +2 more
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1983
This paper describes a proposal to a short Reference Year, selected for building thermal analysis and solar energy analysis. The approach used for development of the SRY climate model are briefly discussed. Furthermore the outline of a computer program for calculation of the SRY model parameter is illustrated and the results of parameter calculation ...
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This paper describes a proposal to a short Reference Year, selected for building thermal analysis and solar energy analysis. The approach used for development of the SRY climate model are briefly discussed. Furthermore the outline of a computer program for calculation of the SRY model parameter is illustrated and the results of parameter calculation ...
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SRY AND SEX DETERMINATION IN MAMMALS
Annual Review of Genetics, 1993INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71 CLONING OF SRY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 EQUIVALENCE OF SRY AND TDF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75 SRY IN OTHER SPECIES . . . . . . . . . . . . . . . . . . . . . . . . . .
P N, Goodfellow, R, Lovell-Badge
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