Results 1 to 10 of about 20,591 (123)

Global genome analysis of the downstream binding targets of testis determining factor SRY and SOX9. [PDF]

PLoS ONE, 2012
A major event in mammalian male sex determination is the induction of the testis determining factor Sry and its downstream gene Sox9. The current study provides one of the first genome wide analyses of the downstream gene binding targets for SRY and SOX9
Ramji K Bhandari, Md M Haque, Michael K Skinner   +2 more
doaj   +6 more sources

Structure-function relationships in human testis-determining factor SRY: an aromatic buttress underlies the specific DNA-bending surface of a high mobility group (HMG) box. [PDF]

J Biol Chem, 2014
Human testis determination is initiated by SRY, a Y-encoded architectural transcription factor. Mutations in SRY cause 46 XY gonadal dysgenesis with female somatic phenotype (Swyer syndrome) and confer a high risk of malignancy (gonadoblastoma). Such mutations cluster in the SRY high mobility group (HMG) box, a conserved motif of specific DNA binding ...
Racca JD, Chen YS, Maloy JD, Wickramasinghe N, Phillips NB, Weiss MA.   +5 more
europepmc   +4 more sources

The human testis-determining factor SRY localizes in midbrain dopamine neurons and regulates multiple components of catecholamine synthesis and metabolism. [PDF]

J Neurochem, 2012
J. Neurochem. (2012) 122, 260–271.AbstractThe male gender is determined by the sex‐determining region on the Y chromosome (SRY) transcription factor. The unexpected action of SRY in the control of voluntary movement in male rodents suggests a role in the regulation of dopamine transmission and dopamine‐related disorders with gender bias, such as ...
Czech DP, Lee J, Sim H, Parish CL, Vilain E, Harley VR.   +5 more
europepmc   +5 more sources

DMRT1 is a testis-determining gene in rabbits and is also essential for female fertility

eLife, 2023
DMRT1 is the testis-determining factor in several species of vertebrates, but its involvement in mammalian testes differentiation, where SRY is the testis-determining gene, remains ambiguous.
Emilie Dujardin, Marjolaine André, Aurélie Dewaele, Béatrice Mandon-Pépin, Francis Poulat, Anne Frambourg, Dominique Thépot, Luc Jouneau, Geneviève Jolivet, Eric Pailhoux, Maëlle Pannetier   +10 more
doaj   +1 more source

Loss of circSRY reduces γH2AX level in germ cells and impairs mouse spermatogenesis

Life Science Alliance, 2023
The study proved that the loss of Sry circular RNA in testis causes impaired spermatogenesis, and this damage may be related to the decline in the γH2AX level during the meiosis I stage.
Yanze Song, Min Chen, Yingfan Zhang, Jiayi Li, Bowen Liu, Na Li, Min Chen, Miaomiao Qiao, Nan Wang, Yuanwei Cao, Shan Lu, Jian Chen, Wen Sun, Fei Gao, Haoyi Wang   +14 more
doaj   +1 more source

RNA beacons for detecting the human testis-determining factor [PDF]

, 2021
AbstractThe testis-determining factor (TDF) is an essential transcriptional protein for male differentiation in mammals, expressed along spermatids to early zygotes and, to some extent, in diverse cellular lines. In this study, we developed fluorescent biosensors capable of indicating the presence of TDF.
Diego F. Joseph, Jose Alberto Nakamoto, Pohl Milón   +2 more
openaire   +1 more source

Surgical Sperm Retrieval Techniques for Assisted Reproductive Technology

Düzce Tıp Fakültesi Dergisi, 2022
Intracytoplasmic sperm injection provides in vitro fertilization for many infertility conditions. It is also an important treatment option for fertilization in azoospermic men. Sperm production in azoospermic male testicles is possible. In these patients,
Tahsin Turunç, Mehmet Vehbi Kayra
doaj   +1 more source

Structural basis for proapoptotic activation of Bak by the noncanonical BH3-only protein Pxt1.

PLoS Biology, 2023
Bak is a critical executor of apoptosis belonging to the Bcl-2 protein family. Bak contains a hydrophobic groove where the BH3 domain of proapoptotic Bcl-2 family members can be accommodated, which initiates its activation.
Dahwan Lim, So-Hui Choe, Sein Jin, Seulgi Lee, Younjin Kim, Ho-Chul Shin, Joon Sig Choi, Doo-Byoung Oh, Seung Jun Kim, Jinho Seo, Bonsu Ku   +10 more
doaj   +1 more source

Eight Y chromosome genes show copy number variations in horses [PDF]

Archives Animal Breeding, 2018
Copy number variations (CNVs), which represent a significant source of genetic diversity on the Y chromosome in mammals, have been shown to be associated with the development of many complex phenotypes, such as reproduction and male fertility.
H. Han, H. Han, X. Zhang, X. Zhao, X. Xia, C. Lei, R. Dang   +6 more
doaj   +1 more source

Positional cloning of the PIS mutation in goats and its impact on understanding mammalian sex-differentiation

Genetics Selection Evolution, 2005
In goats, the PIS (polled intersex syndrome) mutation is responsible for both the absence of horns in males and females and sex-reversal affecting exclusively XX individuals.
Pailhoux Eric, Vigier Bernard, Schibler Laurent, Cribiu Edmond P, Cotinot Corinne, Vaiman Daniel   +5 more
doaj   +1 more source