Results 11 to 20 of about 20,710 (238)
Sox6 directly silences epsilon globin expression in definitive erythropoiesis. [PDF]
PLoS Genetics, 2006 Sox6 is a member of the Sox transcription factor family that is defined by the conserved high mobility group (HMG) DNA binding domain, first described in the testis determining gene, Sry.
Zanhua Yi +8 more
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Synergistic effect of SRY and its direct target, WDR5, on Sox9 expression. [PDF]
PLoS ONE, 2012 SRY is a sex-determining gene that encodes a transcription factor, which triggers male development in most mammals. The molecular mechanism of SRY action in testis determination is, however, poorly understood.
Zhen Xu +11 more
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PLoS ONE, 2011 The cascade of molecular events involved in mammalian sex determination has been shown to involve the SRY gene, but specific downstream events have eluded researchers for decades. The current study identifies one of the first direct downstream targets of
Ramji K Bhandari +3 more
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The Human Testis Determining Factor SRY Binds a Nuclear Factor Containing PDZ Protein Interaction Domains [PDF]
Journal of Biological Chemistry, 1997 The human Y-linked testis determining gene SRY encodes a protein with a DNA binding domain from the high mobility group box family. To date, no function has been assigned to amino acid sequences located outside this DNA binding motif. Here, we identify in a yeast two-hybrid screen a PDZ protein termed SIP-1, as an interacting protein with human SRY. In
F, Poulat +7 more
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Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination.
PLoS Biology, 2006 The genes encoding members of the wingless-related MMTV integration site (WNT) and fibroblast growth factor (FGF) families coordinate growth, morphogenesis, and differentiation in many fields of cells during development.
Yuna Kim +9 more
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The Journal of Reproduction and Development, 2020 Testis-brain RNA-binding protein (TB-RBP/Translin) is known to contribute to the translational repression of a subset of haploid cell-specific mRNAs, including protamine 2 (Prm2) mRNA.
Kanako OYAMA +2 more
doaj +1 more source
XX Disorder of Sex Development is associated with an insertion on chromosome 9 and downregulation of RSPO1 in dogs (Canis lupus familiaris). [PDF]
PLoS ONE, 2017 Remarkable progress has been achieved in understanding the mechanisms controlling sex determination, yet the cause for many Disorders of Sex Development (DSD) remains unknown.
Vicki N Meyers-Wallen +13 more
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275. Calmodulin-dependent nuclear import pathway of the testis-determining factor SRY [PDF]
Reproduction, Fertility and Development, 2004 Modulation of the nuclear entry of transcription factors (TFs) and chromatin components is a means by which eukaryotic cells can regulate gene expression in response to extracellular signals and the cell cycle during differentiation and development. TFs and chromatin components access the nucleus through nuclear localisation sequences (NLSs), which ...
G. Kaur +3 more
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eLife, 2014 FOXL2 is a lineage determining transcription factor in the ovary, but its direct targets and modes of action are not fully characterized. In this study, we explore the targets of FOXL2 and five nuclear receptors in murine primary follicular cells.
Adrien Georges +6 more
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Sibling rivalry: Males with more brothers develop larger testes
Ecology and Evolution, 2018 When females mate with multiple partners in a reproductive cycle, the relative number of competing sperm from rival males is often the most critical factor in determining paternity.
Heidi S. Fisher +3 more
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