Review of the Y chromosome and hypertension
Brazilian Journal of Medical and Biological Research, 2000 The Y chromosome from spontaneously hypertensive rats (SHR) has a locus that raises blood pressure 20-25 mmHg. Associated with the SHR Y chromosome effect is a 4-week earlier pubertal rise of testosterone and dependence upon the androgen receptor for the
D. Ely, M. Turner, A. Milsted
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Transcriptional activity of testis-determining factor SRY is modulated by the Wilms’ tumor 1 gene product, WT1 [PDF]
Oncogene, 2003 The Wilms' tumor 1 (WT1) and sex-determining region of the Y chromosome (SRY) genes are essential for development of the mammalian gonads and mutations in these genes are associated with gonadal dysgenesis in humans. The SRY gene encodes a transcription factor with one high-mobility group (HMG) box as a DNA-binding domain.
Yumiko, Matsuzawa-Watanabe +2 more
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Genetic, Genomic and Biophysical Case Study: Familial 46, XY Sex Reversal due to a Novel Inherited Mutation in Human Testis-Determining Factor SRY [PDF]
, 2021 AbstractObjectiveTo describe the clinical, histopathological and molecular features of a novel inheritedSRYallele (p.Met64Val; consensus box position 9) observed within an extensive pedigree: two 46, XY sisters with primary amenorrhea (16 and 14 years of age; probands P1 and P2), their normal father and brother, and an affected paternal XY grandaunt ...
Elisa Vaiani +15 more
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A novel mouse Fgfr2 mutant, hobbyhorse (hob), exhibits complete XY gonadal sex reversal.
PLoS ONE, 2014 The secreted molecule fibroblast growth factor 9 (FGF9) plays a critical role in testis determination in the mouse. In embryonic gonadal somatic cells it is required for maintenance of SOX9 expression, a key determinant of Sertoli cell fate.
Pam Siggers +8 more
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Endocrinology, Diabetes & Metabolism Case Reports, 2022 A male phenotype accompanied by a 45,X karyotype is rare. It may occur due to Y chromosomal translocation or insertion to X/autosome. Clinical presentation may vary depending on the presence of the Y chromosomal locus and the degree of loss of autosome ...
Jananie Suntharesan +2 more
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Pharmaceuticals, 2020 Paeonol, a phenolic ingredient in the genus Paeonia, possesses antioxidant and anti-inflammatory effects. Methotrexate (MTX) is a commonly used chemotherapeutic agent; however, its germ cell damage is a critical problem.
Mohamed A. Morsy +5 more
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Identification, expression, and artificial selection of silkworm epigenetic modification enzymes
BMC Genomics, 2020 Background Understanding the genetic basis of phenotype variations during domestication and breeding is of great interest. Epigenetics and epigenetic modification enzymes (EMEs) may play a role in phenotypic variations; however, no comprehensive study ...
Rui Gao +10 more
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The Molecular Action and Regulation of the Testis-Determining Factors, SRY (Sex-Determining Region on the Y Chromosome) and SOX9 [SRY-Related High-Mobility Group (HMG) Box 9] [PDF]
Endocrine Reviews, 2003 Despite 12 yr since the discovery of SRY, little is known at the molecular level about how SRY and the SRY-related protein, SOX9 [SRY-related high-mobility group (HMG) box 9], initiate the program of gene expression required to commit the bipotential embryonic gonad to develop into a testis rather than an ovary. Analysis of SRY and SOX9 clinical mutant
Vincent R, Harley +2 more
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The Relative Levels of Translin-associated Factor X (TRAX) and Testis Brain RNA-binding Protein Determine Their Nucleocytoplasmic Distribution in Male Germ Cells [PDF]
Journal of Biological Chemistry, 2004 Testis brain RNA-binding protein (TB-RBP), the mouse orthologue of human translin, is an RNA and single-stranded DNA-binding protein abundant in testis and brain. Translin-associated factor X (TRAX) was identified as a protein that interacts with TB-RBP and is dependent upon TB-RBP for stabilization.
Cho, Y S +4 more
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The platelet-derived growth factor signaling system in snapping turtle embryos, Chelydra serpentina: Potential role in temperature-dependent sex determination and testis development [PDF]
General and Comparative Endocrinology, 2009 The platelet-derived growth factor (Pdgf) signaling system is known to play a significant role during embryonic and postnatal development of testes in mammals and birds. In contrast, genes that comprise the Pdgf system in reptiles have never been cloned or studied in any tissue, let alone developing gonads. To explore the potential role of PDGF ligands
Turk, Rhen +3 more
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