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Cloning and Mutational Analysis of SRY
Hormone Research, 1992A candidate for the male sex-determining gene has recently been isolated. This sex-determining gene (SRY) has been found to be mutated in some individuals with failed testis development, and, in mouse transgenesis, the SRY murine homologue (Sry) causes female-to-male sex reversal. The cloning of SRY should facilitate the characterisation of other genes
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Increased Y-Chromosome Detection by SRY Duplexing
Fetal Diagnosis and Therapy, 2012<b><i>Objective:</i></b> Determining fetal sex noninvasively is dependent of a robust assay. We designed a novel <i>SRY</i> assay and combined it with a <i>SRY</i> assay from literature forming a duplex assay with the same fluorescent dye to increase detection of Y-chromosome at low cell-free fetal DNA or
Hansen, Morten Høgh +2 more
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SRY Evolution in Cebidae (Platyrrhini: Primates)
Journal of Molecular Evolution, 2002Sex determination in mammals is dependent on the presence of SRY, which codes for a protein with a DNA binding motif (the HMG-box domain). Here we analyze the evolution of SRY among seven genera of New World monkeys belonging to the family Cebidae. Estimates of the number of synonymous and nonsynonymous substitutions indicated the absence of positive ...
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Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation, 2011
We described the clinical, cytogenetic and molecular findings of 17 clinical equine cases presented for abnormal sexual development and infertility. Six horses with an enlarged clitoris had an XX, SRY-negative genotype, which displayed male-like behavior (adult individuals).
D A F, Villagómez +9 more
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We described the clinical, cytogenetic and molecular findings of 17 clinical equine cases presented for abnormal sexual development and infertility. Six horses with an enlarged clitoris had an XX, SRY-negative genotype, which displayed male-like behavior (adult individuals).
D A F, Villagómez +9 more
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Molecular evolution of Sry and Sox gene
Gene, 2000The mammalian Sry on the short arm of the Y chromosome encodes a nuclear factor-like protein harboring a DNA-binding domain known as the HMG box. The Sox genes encode similar factor like proteins, but the sequence similarity of the HMG box to that of Sry is variable as being at least 60%.
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Sry, Sox9 and mammalian sex determination
2001Sry is the Y-chromosomal gene that acts as a trigger for male development in mammalian embryos. This gene encodes a high mobility group (HMG) box transcription factor that is known to bind to specific target sequences in DNA and to cause a bend in the chromatin.
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2021
Aim. 5??-reductase is an enzyme that converts testosterone to 5??-dihydrotestosterone (DHT) in peripheral tissues. Deficiency of the enzyme 5??-reductase causes a disturbance of the formation of the external genitalia before birth. The polymorphism Val89Leu of SRD5??2 gene is associated with decreased activity of the enzyme 5-alpha-reductase-2. Methods.
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Aim. 5??-reductase is an enzyme that converts testosterone to 5??-dihydrotestosterone (DHT) in peripheral tissues. Deficiency of the enzyme 5??-reductase causes a disturbance of the formation of the external genitalia before birth. The polymorphism Val89Leu of SRD5??2 gene is associated with decreased activity of the enzyme 5-alpha-reductase-2. Methods.
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SRY and mammalian sex determination.
Current topics in developmental biology, 1996This chapter discusses the understanding of the biology of sry and sex determination particularly what is known of the biochemical basis of sry function and its relationship to the other genes in the sex determination pathway. Most importantly, it attempts to identify those areas, in which ignorance is greatest and address some of the issues that might
Greenfield, A., Koopman, P.
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