Results 71 to 80 of about 63,661 (296)

Abnormal white matter tracts resembling pencil fibers involving prefrontal cortex (Brodmann area 47) in autism: a case report. [PDF]

, 2016
BackgroundAutism is not correlated with any neuropathological hallmark as the brain of autistic individuals lack defined lesions. However, previous investigations have reported cortical heterotopias and local distortion of the cytoarchitecture of the ...
Ariza, Jeanelle, Hashemi, Ezzat, Lechpammer, Mirna, Martínez-Cerdeño, Verónica, Noctor, Stephen C   +4 more
core   +1 more source

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Low genetic variability, female-biased dispersal and high movement rates in an urban population of Eurasian badgersMeles meles [PDF]

, 2008
1. Urban and rural populations of animals can differ in their behaviour, both in order to meet their ecological requirements and due to the constraints imposed by different environments.
Bijlsma, Brownstein, Carpenter, Carpenter, Carpenter, Cheeseman, Christian, Clements, Cresswell, da Silva, Davison, Davison, Ditchkoff, Domingo-Roura, Doncaster, Dugdale, Dugdale, Engel, Estes, Evans, Favre, Frantz, Frantz, Frantz, Gottelli, Griffiths, Hardy, Harris, Harris, Huck, Huck, Huck, Kalinowski, Kowalczyk, Kruuk, Langbein, Loiselle, Macdonald, Marmi, Marshall, McKelvey, McKelvey, Miller, Miller, Mills, Page, Pertoldi, Pope, Queller, Raymond, Roper, Rousset, Scheppers, Schley, Smal, Taberlet, Taberlet, Taylor, Tuyttens, Tuyttens, van Oosterhout, Vekemans, Waits, Walsh, Wilberg, Woodroffe, Woodroffe   +66 more
core   +2 more sources

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Mixed gonadal dysgenesis in 45,X Turner syndrome with gene [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2015
Turner syndrome is the most common chromosomal disorder in girls. Various phenotypic features show depending upon karyotype from normal female through ambiguous genitalia to male.
Jae Yeop Jung, Sohyoung Yang, Eun-Hwan Jeong, Ho-Chang Lee, Yong-Moon Lee, Heon-Seok Han, Kyung Hee Yi   +6 more
doaj   +1 more source

46,XX/SRY-negative true hermaphrodite

Fertility and Sterility, 2010
To describe genetic evaluation and response to surgery and letrozole therapy of a 46,XX/SRY-negative true hermaphrodite.Case report.University Medical Center.Nineteen-year-old male with penile hypospadias, micropenis, and crytorchidism at the time of birth.Unilateral gonadectomy, and contralateral conservative gonadal surgery, followed by therapy with ...
Parada-Bustamante, Alexis, Ríos, Rafael, Ebensperger, Mauricio, Lardone, María Cecilia, Piottante, Antonio, Castro, Andrea   +5 more
openaire   +3 more sources

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

A case report of hermaphrodite goat: clinical and genetic approach [PDF]

Eurasian Journal of Veterinary Sciences
This case report describes clinical examination and cytogenetic and molecular genetic analyses of a hermaphrodite mixed Maltese breed goat that was referred to the Gynecology Clinic of the Faculty of Veterinary Medicine, Selcuk University in 2010.
Çağlayan Özel, , Gonca Şen, Mustafa Hitit, Nadir Koçak, Aydın Güzeloğlu, Ahmet Semacan, Ercan Kurar, Ercan   +8 more
doaj  

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source