Results 51 to 60 of about 63,661 (296)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Sry is a transcriptional activator [PDF]
Molecular Endocrinology, 1994 The SRY gene functions as a genetic switch in gonadal ridge initiating testis determination. The mouse Sry and human SRY open reading frames (ORFs) share a conserved DNA-binding domain (the HMG-box) yet exhibit no additional homology outside this region.
R A, Dubin, H, Ostrer
openaire +3 more sources
Low SOX12 Expression Is Correlated With Poor Prognosis in Patients With Gastric Cancer
Technology in Cancer Research & Treatment, 2020 Background: SRY-related HMG box-12, which is associated with the prognosis of cancer, has been frequently described. However, both SRY-related HMG box-12 expression and its relationship with clinicopathological variables and patient survival have not ...
Kan-kan Yang MD +4 more
doaj +1 more source
Generation of Human Epidermis-Derived Mesenchymal Stem Cell-like Pluripotent Cells and their reprogramming in mouse chimeras [PDF]
, 2011 Stem cells can be derived from the embryo (embryonic stem cells, ESCs), from adult tissues (adult stem cells, ASCs), and by induction of fibroblasts (induced pluripotent stem cells, iPSs).
Bing Huang +21 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Brain Sexual Differentiation and Requirement of SRY: Why or Why Not?
Frontiers in Neuroscience, 2017 Brain sexual differentiation is orchestrated by precise coordination of sex steroid hormones. In some species, programming of select male brain regions is dependent upon aromatization of testosterone to estrogen.
Cheryl S. Rosenfeld +3 more
doaj +1 more source
JCRPE, 2020 The 46,XX ovotesticular disorder of sex development (DSD) is rarely observed in humans. This disorder is generally described as ambiguous genitalia with the presence of ovarian and testicular tissues in different gonads or in the same gonad.
Eda Mengen +3 more
doaj +1 more source
A Korean boy with 46,XX testicular disorder of sex development caused by duplication [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2014 The 46,XX testicular disorder of sex development (DSD), also known as 46,XX male syndrome, is a rare form of DSD and clinical phenotype shows complete sex reversal from female to male.
Gyung Min Lee +3 more
doaj +1 more source
Loss of circSRY reduces γH2AX level in germ cells and impairs mouse spermatogenesis
Life Science Alliance, 2023 The study proved that the loss of Sry circular RNA in testis causes impaired spermatogenesis, and this damage may be related to the decline in the γH2AX level during the meiosis I stage.
Yanze Song +14 more
doaj +1 more source
Clinicopathological significance of loss of Y chromosome in male meningiomas. [PDF]
J PatholAbstract Male meningiomas, comprising approximately 30% of all meningiomas, are more frequently high‐grade and associated with poorer clinical outcomes compared to their female counterparts. Although Y chromosome alterations have been studied in various male‐predominant tumors, a limited number of studies have evaluated their role in meningiomas.
Sakaguchi M +7 more
europepmc +2 more sources