Results 221 to 230 of about 192,408 (300)

First‐In‐Human Safety, Pharmacokinetics, and Pharmacodynamics of VENT‐02 Freebase, a CNS‐Penetrant NLRP3 Inhibitor

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT The NLRP3 inflammasome is a central mediator of innate immunity and a key driver of inflammatory and neurodegenerative diseases. VENT‐02 is orally bioavailable, central nervous system‐penetrant, selective small‐molecule inhibitor of NLRP3. This first‐in‐human, randomized, double‐blind, placebo‐controlled study assessed the safety, tolerability,
Lisanne C. A. Smidt, Matthijs Moerland, Manon A. A. Jansen, Philip H. C. Kremer, Alexandra A. J. Sille, Pamela K. Strugala, Erica S. Klaassen, Anick Auger, Silvana Jananji, Rania Faidi, Kelly A. Pike, Loraine Warner, Andre Matta, Xavier Valencia, Ofer Spiegelstein   +14 more
wiley   +1 more source

CRISPR/Cas9-based knockout of BnaLYK compromises pattern-triggered immunity and resistance to Sclerotinia sclerotiorum in Brassica napus. [PDF]

BMC Plant Biol
Liu Y, Yin X, Jin P, Zhang H.
europepmc   +1 more source

Assessing the Progress of Stock Rebuilding in the Northeast Atlantic Against Levels That Can Produce Maximum Sustainable Yield

Fish and Fisheries, Volume 27, Issue 3, Page 519-536, May 2026.
ABSTRACT Rebuilding fish stocks to levels above which they produce Maximum Sustainable Yield (MSY) is a management aim for all European commercially exploited stocks. Progress is typically monitored against the fishing mortality that produces MSY in the long term (FMSY), however, the corresponding biomass target (BMSY) is rarely evaluated nor reported.
Henning Winker, Massimiliano Cardinale, Rishi Sharma, Laurence T. Kell, Iago Mosqueira, Christopher Griffiths   +5 more
wiley   +1 more source

The contributions of genetic diversity to the performance of sun-cured tobacco. [PDF]

BMC Plant Biol
Kurt D, Saygili İ, Kinay A, Karakoc E.
europepmc   +1 more source

Global Analysis of Shallow Underwater Fish Observation Research: 70 Years of Progress, Persistent Geographic Biases and a Path Forward

Fish and Fisheries, Volume 27, Issue 3, Page 607-626, May 2026.
ABSTRACT Marine ecosystems are increasingly threatened by overfishing, pollution, coastal development and climate change, underscoring the need for long‐term, representative information on key fish populations and habitats to inform management and policy.
Angus John van Wyk, Rick D. Stuart‐Smith, Jordan S. Goetze, Eva Maire, Elodie Heyns‐Veale, Kaylee Smit, Tim J. Langlois, M. Aaron MacNeil, Alejandro Pérez‐Matus, Amanda T. Lombard, Ana Carolina, Christy Semmens, Ella Clausius, Fernanda A. Rolim, Jonathan S. Lefcheck, Jacquomo Monk, Joanna K. Schmid, Katherine Tattersall, Laura Ghigliotti, Luther Adams, Melita Samoilys, Pascale Chabanet, Paul Whomersley, Peter Walsh, Reiji Masuda, Russell Brainard, Anthony Bernard   +26 more
wiley   +1 more source

Development and characterization of SSR markers in <i>Phoebe zhennan</i>. [PDF]

PeerJ
Liang Q, Jia Y, Shi R, Zhao D, Luo M.
europepmc   +1 more source

A meta-analysis of neural systems underlying delay discounting: Implications for transdiagnostic research. [PDF]

Imaging Neurosci (Camb)
Lakhani NV, Souther MK, Boateng B, Kable JW.   +3 more
europepmc   +1 more source

Incorporation of Kombucha Bacterial Cellulose to Produce Tomato Leathers via Cast‐Tape Drying

Journal of Food Process Engineering, Volume 49, Issue 5, May 2026.
Tomato leathers containing kombucha bacterial cellulose (KBC) were produced by cast‐tape drying. The incorporation of KBC changes the drying time of tomato leathers by cast‐tape drying. Tomato leathers containing KBC had antioxidant properties and consumer acceptability similar to tomato leather without KBC.
Fernando Ribeiro de Souza, Raquel da Silva Simão, Diego Castro Squinello, Luisa Maria Figueiredo Lima, João Borges Laurindo, Germán Ayala Valencia   +5 more
wiley   +1 more source

Analysis of EST-SSR characteristics of prickly ash transcriptome and development of molecular markers. [PDF]

Sci Rep
Liu J, Zhuo S, Xiang S, Du J, Zhang R, Tian A, Liu L, Cai X, Ma Z, Ren Y, Chen Z.   +10 more
europepmc   +1 more source