Results 191 to 200 of about 647,762 (284)

Spicule Morphology and Nutritional Composition of Two Tropical Sea Cucumbers (Stichopus horrens and Holothuria leucospilota) From Sabah, Malaysia

open access: yesAquaculture, Fish and Fisheries, Volume 6, Issue 5, October 2026.
ABSTRACT Accurate species identification is essential to ensure authenticity and traceability in the beche‐de‐mer (BDM) trade, whereas nutritional composition data provide important information for evaluating the nutritional value and aquaculture potential of sea cucumber species.
Noora Barzkar   +7 more
wiley   +1 more source

Cardiovascular Exercise Drives Neuroprotection in a Mouse Model of Spinocerebellar Ataxia 1 Via Rescue of Aberrant Splicing

open access: yesAnnals of Neurology, Volume 100, Issue 4, Page 850-866, October 2026.
Objective Spinocerebellar ataxia 1 (SCA1) is a fatal hereditary neurodegenerative disorder with no approved therapies, and gene‐targeting strategies have thus far failed in clinical trials. Exercise remains the only intervention shown to provide clinical benefit in patients with spinocerebellar ataxias (SCAs), yet the underlying mechanisms remain ...
Isabel Soto   +12 more
wiley   +1 more source

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3513-3526, October 2026.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley   +3 more
wiley   +1 more source

Complete Chloroplast Genomes of Five Ulmus pumila Cultivars: Comparative Analysis, Evolutionary Dynamics, and Germplasm Authentication Implications

open access: yesEcology and Evolution, Volume 16, Issue 10, October 2026.
We sequenced and characterized the complete chloroplast genomes of five Ulmus pumila cultivars, which possess typical circular quadripartite structures (159,391–159,769 bp, 35.47%–35.56% GC) encoding 131–133 genes and identified abundant SSRs, long repeats, and core hypervariable molecular markers (trnH‐GUG_psbA, ndhF_rpl32), while IR boundary and ...
Ning Wang   +8 more
wiley   +1 more source

Plastid Phylogenomics of Elatostemateae (Urticaceae): Insights Into Structural Variation and Phylogenetic Relationships

open access: yesEcology and Evolution, Volume 16, Issue 10, October 2026.
This study leverages complete plastid and nuclear ribosomal DNA sequences from 40 species to resolve the complex phylogeny and organellar genome evolution of the diverse plant tribe Elatostemateae. The analysis uncovered significant plastome structural variations, including novel inversions and a rare mitochondrial DNA integration event, and identified
Long‐Fei Fu   +5 more
wiley   +1 more source

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