Results 171 to 180 of about 64,955 (305)

Divergent Mechanisms of Antidepressant Efficacy: A Unified Computational Comparison of Synaptogenesis, Stabilization, and Tonic Inhibition in a Model of Depression. [PDF]

Cureus
Cheung N.
europepmc   +1 more source

Glutathione‐Related Metabolite Levels and Enzyme Activities in Depression: A Systematic Review and Meta‐Analysis

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
We conducted a systematic review and meta‐analysis to compare the levels of glutathione‐related metabolites. Our meta‐analysis indicated significantly decreased activity of glutathione‐peroxidase in patients with depression compared with healthy controls, while the levels of glutathione and glutathione reductase were not significantly different between
Takahide Etani, Nobuaki Hondo, Sho Moriguchi, Kazunari Yoshida, Sotaro Moriyama, Koki Takahashi, Tahichi Moritake, Yumina Nakamura, Ryoma Kani, Shiori Honda, Masataka Wada, Sakiko Tsugawa, Yukino Mori, Hikari Segawa, Tony Kaku, Hiroyuki Uchida, Shinichiro Nakajima   +16 more
wiley   +1 more source

The evolution of SSRI research: trajectories of knowledge domains across four decades. [PDF]

BMC Psychiatry
Westphal L, Gräf DD, Hallgreen CE.
europepmc   +1 more source

Comparative Sleep Architecture Profiles of Antidepressants in Mice: Pharmacological Characterization of Paroxetine, Sertraline, Duloxetine, Mirtazapine and Vortioxetine

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
This study compared five antidepressants (paroxetine, sertraline, duloxetine, mirtazapine, and vortioxetine) in mice using EEG/EMG, revealing distinct effects on REM and NREM sleep. The figure illustrates changes in sleep architecture during the light phase (ZT0–12).
Junya Maruoka, Ryo Egami, Yuto Akita, Kohei Kozuka, Yusuke Kakumoto, Tetsuro Kikuchi, Kazuhiko Kume   +6 more
wiley   +1 more source

Efficacy of Selective Serotonin Reuptake Inhibitors for the Treatment of Chronic Pain and Comorbid Depression in Individuals With Fibromyalgia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]

Cureus
Alfawaz S, Aljeshi Z, Aldandan J, Alharthi M, Alnefaie M, Babelli N, Alshehri N, Alsenaidi S, Albalawi W, Alghamdi G, Alsufyani S, Alfeeli A.   +11 more
europepmc   +1 more source

A Systematic Review and Narrative Synthesis Comparing the Efficacy of Dapoxetine and Clomipramine in the Management of Premature Ejaculation

Trends in Urology &Men's Health, Volume 17, Issue 3, June 2026.
ABSTRACT Dapoxetine (on‐demand SSRI) and clomipramine (daily TCA) are commonly used for premature ejaculation (PE), yet direct comparative evidence remains limited and heterogeneous, particularly because dapoxetine is administered on‐demand while clomipramine requires daily dosing. To systematically review evidence comparing dapoxetine and clomipramine
Khaled Moheyiddin, Ahmed H. Hassan
wiley   +1 more source

Reinitiation of antidepressant pharmacotherapy among patients discharged from the hospital: A population-based cohort study. [PDF]

PLOS Ment Health
Abu-Ashour W, Gamble JM, Hawboldt J, Sale JEM.   +3 more
europepmc   +1 more source

Tricyclics and SSRIs [PDF]

British Journal of Psychiatry, 1996
R. J. Bowskill, P. K. Bridges
openaire   +1 more source

Acute‐Phase Interventions After Self‐Harm for Preventing Suicide and Recurrence: A Systematic Review and Meta‐Analysis

Acta Psychiatrica Scandinavica, Volume 153, Issue 6, Page 610-626, June 2026.
ABSTRACT Introduction Suicide risk is markedly elevated following presentation after self‐harm, yet the evidence base for interventions initiated in the immediate post‐presentation period has not been synthesized with specific attention to this high‐risk window. Clarifying which early interventions may reduce adverse outcomes is essential for informing
Guilherme Pimenta Roncete, Luis C. Farhat, Loren Beiram, Bianca Besteti Fernandes Damiano, Craig J. Bryan, Karina L. Ramirez, Euripedes Constantino Miguel, Rodolfo Furlan Damiano   +7 more
wiley   +1 more source

Deep learning using electroencephalogram (EEG) data for diagnosing and predicting SSRI response in major depressive disorder. [PDF]

Commun Med (Lond)
Olbrich S, Jaworska N, de la Salle S, Knott V, Blier P, Brunovsky M, Welt T, de Bardeci M, Teng-Ip C.   +8 more
europepmc   +1 more source