Results 1 to 10 of about 7,850 (192)

Molecular Characterization of the Multidrug Resistant Escherichia coli ST131 Clone [PDF]

Pathogens, 2015
Escherichia coli ST131 is a recently emerged and globally disseminated multidrug resistant clone associated with urinary tract and bloodstream infections in both community and clinical settings.
Mark A Schembri, Nouri L Ben Zakour, Minh-Duy Phan   +2 more
exaly   +11 more sources

Global High-Risk <i>Escherichia coli</i> Clones in Moroccan Aquatic Settings: Genomic Evidence of Environmental Dissemination. [PDF]

Int J Microbiol
Background Globally disseminated high‐risk Escherichia coli (E. coli) clones are major drivers of multidrug resistance (MDR) and severe clinical infections. Their presence in aquatic ecosystems represents a growing One Health concern, particularly in regions where wastewater management remains limited.
Aiddi A, Zerdani I, Khazaz A, Mguild H, El Hamouchi A, Nayme K.   +5 more
europepmc   +2 more sources

Comparative genomic and phenotypic analysis of Escherichia coli ST1193 and ST131 from urinary and bloodstream infections: insights into resistance, virulence, and divergent strategies [PDF]

BMC Infectious Diseases
Background The global dissemination of multidrug-resistant (MDR) Escherichia coli (E. coli) clones, particularly the pandemic ST131 and the emerging ST1193, poses a serious public health threat.
Qian Zeng, Su Wang, Shuzhen Xiao, Huifang Liu, Feifei Gu, Lizhong Han, Xiaofei Jiang   +6 more
doaj   +2 more sources

Virulence factors and outcomes in bacteremia caused by extended-spectrum β-lactamase-producing uropathogenic Escherichia coli ST131-H30Rx in a Swedish county [PDF]

BMC Infectious Diseases
Background Escherichia coli ST131 and clade H30Rx are the most prevalent extended-spectrum β-lactamase-producing E. coli (ESBL-EC) causing bacteremia and urinary tract infections globally and in Sweden.
Vidar Möller, Jenny Welander, Maud Nilsson, Mai Thi-Huyen Nguyen, Martin Holmbom, Håkan Hanberger, Lennart E. Nilsson, Åse Östholm, Björn Berglund   +8 more
doaj   +2 more sources

Multidrug-Resistant Pathogen Clonal Spread in Nigeria: A Systematic Review and Meta-Analysis. [PDF]

Health Sci Rep
ABSTRACT Background and Aim The rapid dissemination of multidrug‐resistant (MDR) bacterial clones poses a global health threat and limits treatment options. Understanding the dynamics of bacterial clones in Nigeria is essential for developing effective control strategies. This systematic review aimed to track MDR pathogen clones in Nigeria. Methods The
Ugbo EN, Afiukwa FN, Effendi MH, Darkwah S, Odoom A, Donkor ES.   +5 more
europepmc   +2 more sources

Structure-Guided Optimization and Biological Validation of 1,3,4-Thiadiazole-Based SIRT2 Inhibitors Reinforcing Channel Entrance Interactions. [PDF]

Drug Dev Res
ABSTRACT SIRT2, the cytoplasmic member of the sirtuin family, is generally acknowledged to promote cancer and contribute to the progression of various pathologies, including neurodegeneration, inflammation, obesity, and bacterial infection through the deacetylation of target substrates.
Aksel AB, Ozgencil F, Bakar-Ates F, Gunindi HB, Massarotti A, Ozkan E, Kaya SG, Gozelle M, Ozkan Y, Eren G.   +9 more
europepmc   +2 more sources

A Nosocomial Respiratory Infection Outbreak of Carbapenem-Resistant Escherichia coli ST131 With Multiple Transmissible blaKPC–2 Carrying Plasmids

Frontiers in Microbiology, 2020
Escherichia coli sequence type 131 (ST131) is well known for its multidrug resistance profile. Carbapenems have been considered the treatment of choice for E.
Ruiting Lan, Wen Zhang, Haijian Zhou
exaly   +3 more sources

Emergence of Escherichia coli sequence type 131 clone carrying blaCTX-M genes in Guilan Province, Northern Iran [PDF]

Microbiology Spectrum
Extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales complicate clinical management, as they are resistant to standard antibiotics and often necessitate intricate treatment plans.
Samaneh Kazemi, Ali Mojtahedi, Farzaneh Hosseini   +2 more
doaj   +2 more sources

Basic reproduction number varies markedly between closely related pandemic Escherichia coli clones [PDF]

Nature Communications
Extra-intestinal pathogenic Escherichia coli ubiquitously colonize the human gut and represent clinically the most significant bacterial species causing urinary tract infections and bacteremia. During the last two decades clades of the ST131 lineage have
Fanni Ojala, Henri Pesonen, Rebecca A. Gladstone, Tommi Mäklin, Gerry Tonkin-Hill, Pekka Marttinen, Jukka Corander   +6 more
doaj   +2 more sources

Transmission dynamics of Escherichia coli sequence type 131 in households—a one health prospective cohort study [PDF]

Nature Communications
Escherichia coli sequence type 131 (ST131) is a major cause of community-onset, multidrug-resistant extraintestinal infections. The transmission and carriage dynamics associated with E. coli ST131’s global prevalence remain poorly understood.
Rebecca Lynn Perez, Hao Chung The, Kithalakshmi Vignesvaran, Wei Cong Tan, Melissa Sin Hui Chua, En Ying Tan, Si Yu Peng, Lingyue Zhou, Shweta Rajkumar Singh, Wesley Yeung, Ivan Seah, Jeanette Teo, Kyaw Thu Aung, Cheng Yee Tang, Rick Twee-Hee Ong, Ben S. Cooper, Ritu Banerjee, Paul Anantharajah Tambyah, Yin Mo   +18 more
doaj   +2 more sources