Results 211 to 220 of about 835,285 (264)

Stability indicating methods for the determination of clozapine

Journal of Pharmaceutical and Biomedical Analysis, 2002
Five new selective, precise and accurate methods are described for the determination of clozapine in the presence of its main degradation product. Method A utilizes the second and third derivative spectrophotometry at 315 and 305 nm, respectively. Method B is RSD(1) spectrophotometric method based on the simultaneous use of the first derivative of ...
Nagiba Y, Hasan, Mohamed A, Elkawy, Badr E, Elzeany, Nour E, Wagieh   +3 more
openaire   +2 more sources

A stability indicating LC method for zolmitriptan

Journal of Pharmaceutical and Biomedical Analysis, 2005
A gradient, reversed-phase liquid chromatographic (RP-LC) assay method was developed for the quantitative determination of zolmitriptan, used to treat severe migraine headaches. The developed method is also applicable for the related substances determination in bulk drugs. The chromatographic separation was achieved on a Waters X Terra RP18, 250 mm x 4.
B Mallikarjuna, Rao, M K, Srinivasu, G, Sridhar, P Rajender, Kumar, K B, Chandrasekhar, Aminul, Islam   +5 more
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Stability indicating methods for the determination of aceclofenac

Il Farmaco, 2003
Five new selective, precise and accurate methods for the determination of aceclofenac in the presence of its degradation product; diclofenac are described. Method A utilizes third derivative spectrophotometry at 242 nm. Method B is RSD(1) spectrophotometric method based on the simultaneous use of the first derivative of ratio spectra and measurement at
N Y, Hasan, M, Abdel-Elkawy, B E, Elzeany, N E, Wagieh   +3 more
openaire   +2 more sources

A Stability Indicating Method for Dipyridamole

Drug Development and Industrial Pharmacy, 1993
AbstractAn HPLC method for the assay and chromatographic purity assessment of dipyridamole raw material and capsule product was developed. A mobile phase composing of methanol: aq 200 mM pentane sulphonic acid, sodium salt, [70:30 v/v], had triethylamine added [2ml/L] and was then adjusted to pH 3.0 with phosphoric acid.
Janet H Bridle, Mark T Brimble
openaire   +1 more source

A validated stability indicating LC method for oxcarbazepine

Journal of Pharmaceutical and Biomedical Analysis, 2007
The present paper describes the development of a stability indicating reversed phase liquid chromatographic (RPLC) method for oxcarbazepine in the presence of its impurities and degradation products generated from forced decomposition studies. The drug substance was subjected to stress conditions of hydrolysis, oxidation, photolysis and thermal ...
D B, Pathare, A S, Jadhav, M S, Shingare
openaire   +2 more sources

A stability-indicating liquid chromatographic method for Lomustine

Journal of Pharmaceutical and Biomedical Analysis, 2011
A simple, inexpensive and rapid liquid chromatography (LC) method has been developed for the quantitative determination of Lomustine, an chemotherapy drug. Degradation studies were performed on the bulk drug by heating to 60 °C, exposure to UV light at an energy of 200 Wh/m(2)and to visible light at an illumination of not less than 1.2 million lux ...
K Rama, Seshaiah, Sudip Kr, Samanta, V Krishna, Reddy, V V N K V, Prasadaraju, K, Mukkanti, V Ranga, Reddy   +5 more
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A Validated Stability Indicating LC Method for Nateglinide

Drug Development and Industrial Pharmacy, 2007
A simple, isocratic, rapid and accurate reverse phase high-performance liquid chromatography (RP-HPLC) method was developed for the quantitative determination of Nateglinide. The developed method is also applicable for determination of related substance in bulk drugs.
D B, Pathare, A S, Jadhav, M S, Shingare
openaire   +2 more sources

Stability-indicating methods for the determination of sumatriptan succinate

Journal of Pharmaceutical and Biomedical Analysis, 2003
Four stability-indicating methods were developed for the determination of sumatriptan succinate in the presence of its degradation products. The first method depends on the quantitative densitometric evaluation of thin-layer chromatography of sumatriptan succinate in the presence of its degradation products without any interference.
L I, Bebawy, A A, Moustafa, N F, Abo-Talib   +2 more
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Trimetazidine: stability indicating RPLC assay method

Journal of Pharmaceutical and Biomedical Analysis, 2001
An accurate, specific and reproducible reversed phase liquid chromatographic method for the determination of trimetazidine hydrochloride in presence of its degradation products is reported. The mobile phase consisted of water-acetonitrile-triethylamine (90:10:0.1, v/v/v) adjusted with o-phosphoric acid to a pH of 3.3. Chromatography was performed using
S O, Thoppil, P D, Amin
openaire   +2 more sources

Stability indicating LC method for the determination of pipamperone

Journal of Pharmaceutical and Biomedical Analysis, 2005
A high performance liquid chromatographic method for the determination of pipamperone in the presence of one related impurity and its degradation products is described. The method is based on the use of an amide functionalized bonded phase column (LC-ABZ+ Plus) and a mobile phase of acetonitrile-tetrahydrofuran-sodium phosphate monobasic (0.05 M, pH 6 ...
H, Trabelsi, I E, Hassen, S, Bouabdallah, K, Bouzouita, F, Safta   +4 more
openaire   +2 more sources